Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity
RISINGER, A. L, LI, J, BENNETT, M. J, ROHENA, C. C, PENG, J, SCHRIEMER, D. C, MOOBERRY, S. L
Published in Cancer research (Chicago, Ill.) (15.11.2013)
Published in Cancer research (Chicago, Ill.) (15.11.2013)
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AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin
Aznar, Nicolas, Patel, Arjun, Rohena, Cristina C, Dunkel, Ying, Joosen, Linda P, Taupin, Vanessa, Kufareva, Irina, Farquhar, Marilyn G, Ghosh, Pradipta
Published in eLife (04.11.2016)
Published in eLife (04.11.2016)
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Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects
Rohena, Cristina C, Risinger, April L, Devambatla, Ravi Kumar Vyas, Dybdal-Hargreaves, Nicholas F, Kaul, Roma, Choudhary, Shruti, Gangjee, Aleem, Mooberry, Susan L
Published in Molecules (Basel, Switzerland) (02.12.2016)
Published in Molecules (Basel, Switzerland) (02.12.2016)
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Design, Synthesis, and Preclinical Evaluation of 4‑Substituted-5-methyl-furo[2,3‑d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells
Devambatla, Ravi Kumar Vyas, Namjoshi, Ojas A, Choudhary, Shruti, Hamel, Ernest, Shaffer, Corena V, Rohena, Cristina C, Mooberry, Susan L, Gangjee, Aleem
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule Agent N‑(4-Methoxyphenyl)‑N,2,6-trimethyl-6,7-dihydro‑5H‑cyclopenta[d]pyrimidin-4-aminium Chloride and Its Analogues As Antitumor Agents
Gangjee, Aleem, Zhao, Ying, Raghavan, Sudhir, Rohena, Cristina C, Mooberry, Susan L, Hamel, Ernest
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents
Zhang, Xin, Raghavan, Sudhir, Ihnat, Michael, Thorpe, Jessica E., Disch, Bryan C., Bastian, Anja, Bailey-Downs, Lora C., Dybdal-Hargreaves, Nicholas F., Rohena, Cristina C., Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Published in Bioorganic & medicinal chemistry (15.07.2014)
Published in Bioorganic & medicinal chemistry (15.07.2014)
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Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases
Rohena, Cristina C., Peng, Jiangnan, Johnson, Tyler A., Crews, Phillip, Mooberry, Susan L.
Published in Biochemical pharmacology (15.04.2013)
Published in Biochemical pharmacology (15.04.2013)
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Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design
Rohena, Cristina C, Telang, Nakul S, Da, Chenxiao, Risinger, April L, Sikorski, James A, Kellogg, Glen E, Gupton, John T, Mooberry, Susan L
Published in Molecular pharmacology (01.02.2016)
Published in Molecular pharmacology (01.02.2016)
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The Bat Flower: A Source of Microtubule-Destabilizing and -Stabilizing Compounds with Synergistic Antiproliferative Actions
Risinger, April L, Peng, Jiangnan, Rohena, Cristina C, Aguilar, Hector R, Frantz, Doug E, Mooberry, Susan L
Published in Journal of natural products (Washington, D.C.) (25.10.2013)
Published in Journal of natural products (Washington, D.C.) (25.10.2013)
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Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities
Gupton, John T., Yeudall, Scott, Telang, Nakul, Hoerrner, Megan, Huff, Ellis, Crawford, Evan, Lounsbury, Katie, Kimmel, Michael, Curry, William, Harrison, Andrew, Juekun, Wen, Shimozono, Alex, Ortolani, Joe, Lescalleet, Kristin, Patteson, Jon, Moore-Stoll, Veronica, Rohena, Cristina C., Mooberry, Susan L., Obaidullah, Ahmad J., Kellogg, Glen E., Sikorski, James A.
Published in Bioorganic & medicinal chemistry (15.06.2017)
Published in Bioorganic & medicinal chemistry (15.06.2017)
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Antiproliferative Effects of 12-Oxoheteronemin vs Heteronemin
Kittiwisut, Siriporn, Rohena, Cristina C., Yuenyongsawad, Supreeya, Mooberry, Susan L., Plubrukarn, Anuchit
Published in Natural product communications (01.03.2014)
Published in Natural product communications (01.03.2014)
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Cytotoxic effects of anthraquinones from the rhizome of Rheum tataricum on HeLa and MDA-MB-435 cells
Dai, W, Robles, AJ, Rohena, C, Peng, J, Mooberry, SL, Yan, X, Gao, Z
Published in Planta Medica (25.06.2015)
Published in Planta Medica (25.06.2015)
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Conference Proceeding
Abstract P5-03-08: Eribulin impairs the transport of TGF-β type I receptor leading to inhibition of downstream non-canonical TGF-β signaling necessary for cancer metastasis and survival
Rohena, CC, Kaul, R, Risinger, AL, Mooberry, SL
Published in Cancer research (Chicago, Ill.) (15.02.2016)
Published in Cancer research (Chicago, Ill.) (15.02.2016)
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Journal Article
Abstract 837: The unique profile of microtubule stability initiated by the taccalonolides leads to potent antitumor activities
Risinger, April L., Li, Jing, Peng, Jiangnan, Bennett, Melissa J., Rohena, Cristina C., Schriemer, David C., Mooberry, Susan L.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule Agent N -(4-Methoxyphenyl)- N ,2,6-trimethyl-6,7-dihydro-5 H -cyclopenta[ d ]pyrimidin-4-aminium Chloride and Its Analogues As Antitumor Agents
Gangjee, Aleem, Zhao, Ying, Raghavan, Sudhir, Rohena, Cristina C., Mooberry, Susan L., Hamel, Ernest
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article