Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
Singh, Anju, Venkannagari, Sreedhar, Oh, Kyu H, Zhang, Ya-Qin, Rohde, Jason M, Liu, Li, Nimmagadda, Sridhar, Sudini, Kuladeep, Brimacombe, Kyle R, Gajghate, Sachin, Ma, Jinfang, Wang, Amy, Xu, Xin, Shahane, Sampada A, Xia, Menghang, Woo, Juhyung, Mensah, George A, Wang, Zhibin, Ferrer, Marc, Gabrielson, Edward, Li, Zhuyin, Rastinejad, Fraydoon, Shen, Min, Boxer, Matthew B, Biswal, Shyam
Published in ACS chemical biology (18.11.2016)
Published in ACS chemical biology (18.11.2016)
Get full text
Journal Article
PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth
Montal, Emily D., Dewi, Ruby, Bhalla, Kavita, Ou, Lihui, Hwang, Bor Jang, Ropell, Ashley E., Gordon, Chris, Liu, Wan-Ju, DeBerardinis, Ralph J., Sudderth, Jessica, Twaddel, William, Boros, Laszlo G., Shroyer, Kenneth R., Duraisamy, Sekhar, Drapkin, Ronny, Powers, R. Scott, Rohde, Jason M., Boxer, Matthew B., Wong, Kwok-Kin, Girnun, Geoffrey D.
Published in Molecular cell (19.11.2015)
Published in Molecular cell (19.11.2015)
Get full text
Journal Article
Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
Zong, Guanghui, Hu, Zhijian, O’Keefe, Sarah, Tranter, Dale, Iannotti, Michael J, Baron, Ludivine, Hall, Belinda, Corfield, Katherine, Paatero, Anja O, Henderson, Mark J, Roboti, Peristera, Zhou, Jianhong, Sun, Xianwei, Govindarajan, Mugunthan, Rohde, Jason M, Blanchard, Nicolas, Simmonds, Rachel, Inglese, James, Du, Yuchun, Demangel, Caroline, High, Stephen, Paavilainen, Ville O, Shi, Wei Q
Published in Journal of the American Chemical Society (29.05.2019)
Published in Journal of the American Chemical Society (29.05.2019)
Get full text
Journal Article
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M
Published in Nature chemical biology (01.06.2016)
Published in Nature chemical biology (01.06.2016)
Get full text
Journal Article
Total Synthesis of (±)- and (−)-Actinophyllic Acid
Martin, Connor L, Overman, Larry E, Rohde, Jason M
Published in Journal of the American Chemical Society (07.04.2010)
Published in Journal of the American Chemical Society (07.04.2010)
Get full text
Journal Article
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis
Hamanaka, Robert B, Nigdelioglu, Recep, Meliton, Angelo Y, Tian, Yufeng, Witt, Leah J, O'Leary, Erin, Sun, Kaitlyn A, Woods, Parker S, Wu, David, Ansbro, Brandon, Ard, Shawn, Rohde, Jason M, Dulin, Nickolai O, Guzy, Robert D, Mutlu, Gökhan M
Published in American journal of respiratory cell and molecular biology (01.05.2018)
Published in American journal of respiratory cell and molecular biology (01.05.2018)
Get full text
Journal Article
EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth
Issaq, Sameer H, Mendoza, Arnulfo, Kidner, Ria, Rosales, Tracy I, Duveau, Damien Y, Heske, Christine M, Rohde, Jason M, Boxer, Matthew B, Thomas, Craig J, DeBerardinis, Ralph J, Helman, Lee J
Published in Molecular cancer therapeutics (01.07.2020)
Published in Molecular cancer therapeutics (01.07.2020)
Get full text
Journal Article
Total Synthesis of (±)-Actinophyllic Acid
Martin, Connor L, Overman, Larry E, Rohde, Jason M
Published in Journal of the American Chemical Society (18.06.2008)
Published in Journal of the American Chemical Society (18.06.2008)
Get full text
Journal Article
Discovery and Optimization of 2H‑1λ2‑Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer
Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
Get full text
Journal Article
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
Rohde, Jason M., Brimacombe, Kyle R., Liu, Li, Pacold, Michael E., Yasgar, Adam, Cheff, Dorian M., Lee, Tobie D., Rai, Ganesha, Baljinnyam, Bolormaa, Li, Zhuyin, Simeonov, Anton, Hall, Matthew D., Shen, Min, Sabatini, David M., Boxer, Matthew B.
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
Get full text
Journal Article
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays
Urban, Daniel J., Martinez, Natalia J., Davis, Mindy I., Brimacombe, Kyle R., Cheff, Dorian M., Lee, Tobie D., Henderson, Mark J., Titus, Steven A., Pragani, Rajan, Rohde, Jason M., Liu, Li, Fang, Yuhong, Karavadhi, Surendra, Shah, Pranav, Lee, Olivia W., Wang, Amy, McIver, Andrew, Zheng, Hongchao, Wang, Xiaodong, Xu, Xin, Jadhav, Ajit, Simeonov, Anton, Shen, Min, Boxer, Matthew B., Hall, Matthew D.
Published in Scientific reports (06.10.2017)
Published in Scientific reports (06.10.2017)
Get full text
Journal Article
Discovery and Optimization of 2 H -1λ 2 -Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer
Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
Get full text
Journal Article
Total Synthesis of (+)-Nankakurines A and B and (±)-5-epi-Nankakurine A
Altman, Ryan A, Nilsson, Bradley L, Overman, Larry E, Read de Alaniz, Javier, Rohde, Jason M, Taupin, Veronique
Published in Journal of organic chemistry (19.11.2010)
Published in Journal of organic chemistry (19.11.2010)
Get full text
Journal Article
Enantioselective Total Syntheses of Nankakurines A and B: Confirmation of Structure and Establishment of Absolute Configuration
Nilsson, Bradley L, Overman, Larry E, Read de Alaniz, Javier, Rohde, Jason M
Published in Journal of the American Chemical Society (27.08.2008)
Published in Journal of the American Chemical Society (27.08.2008)
Get full text
Journal Article
Structure activity relationships of human galactokinase inhibitors
Liu, Li, Tang, Manshu, Walsh, Martin J., Brimacombe, Kyle R., Pragani, Rajan, Tanega, Cordelle, Rohde, Jason M., Baker, Heather L., Fernandez, Elizabeth, Blackman, Burchelle, Bougie, James M., Leister, William H., Auld, Douglas S., Shen, Min, Lai, Kent, Boxer, Matthew B.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Get full text
Journal Article
Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans
Nakai, Takashi, Perl, Nicholas R, Barden, Timothy C, Carvalho, Andrew, Fretzen, Angelika, Germano, Peter, Im, G-Yoon J, Jin, Hong, Kim, Charles, Lee, Thomas W.-H, Long, Kimberly, Moore, Joel, Rohde, Jason M, Sarno, Renee, Segal, Chrissie, Solberg, Erik O, Tobin, Jenny, Zimmer, Daniel P, Currie, Mark G
Published in ACS medicinal chemistry letters (12.05.2016)
Published in ACS medicinal chemistry letters (12.05.2016)
Get full text
Journal Article
Correction to “An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections”
Parker, Erica N., Cain, Brett N., Hajian, Behnoush, Ulrich, Rebecca J., Geddes, Emily J., Barkho, Sulyman, Lee, Hyang Yeon, Williams, John D., Raynor, Malik, Caridha, Diana, Zaino, Angela, Rohde, Jason M., Zak, Mark, Shekhar, Mrinal, Muñoz, Kristen A., Rzasa, Kara M., Temple, Emily R., Hunt, Diana, Jin, Xiannu, Vuong, Chau, Pannone, Kristina, Kelly, Aya M., Mulligan, Michael P., Lee, Katie K., Lau, Gee W., Hung, Deborah T., Hergenrother, Paul J.
Published in ACS central science (28.09.2022)
Published in ACS central science (28.09.2022)
Get full text
Journal Article
Abstract 434: Characterizing the role of serine metabolism in pediatric sarcomas
Issaq, Sameer, Kidner, Ria, Rohde, Jason, Boxer, Matthew, Helman, Lee
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article