Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin
Herrmann, Alexander, Roesner, Manfred, Werner, Thomas, Hauck, Stefanie M., Koch, Alisha, Bauer, Amelie, Schneider, Martha, Brack-Werner, Ruth
Published in Scientific reports (28.01.2020)
Published in Scientific reports (28.01.2020)
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Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1‑{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3‑b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844)
Ugolini, Antonio, Kenigsberg, Mireille, Rak, Alexey, Vallée, Francois, Houtmann, Jacques, Lowinski, Maryse, Capdevila, Cécile, Khider, Jean, Albert, Eva, Martinet, Nathalie, Nemecek, Conception, Grapinet, Sandrine, Bacqué, Eric, Roesner, Manfred, Delaisi, Christine, Calvet, Loreley, Bonche, Fabrice, Semiond, Dorothée, Egile, Coumaran, Goulaouic, Hélène, Schio, Laurent
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
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Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity
Brenke, Jara K., Popowicz, Grzegorz M., Schorpp, Kenji, Rothenaigner, Ina, Roesner, Manfred, Meininger, Isabel, Kalinski, Cédric, Ringelstetter, Larissa, R'kyek, Omar, Jürjens, Gerrit, Vincendeau, Michelle, Plettenburg, Oliver, Sattler, Michael, Krappmann, Daniel, Hadian, Kamyar
Published in The Journal of biological chemistry (24.08.2018)
Published in The Journal of biological chemistry (24.08.2018)
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Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines
Roesner, Manfred, Capraro, Hans-Georg, Jacobson, Arthur E, Atwell, Louise, Brossi, Arnold, Iorio, Maria A, Williams, Thomas H, Sik, Robert H, Chignell, Colin F
Published in Journal of medicinal chemistry (01.03.1981)
Published in Journal of medicinal chemistry (01.03.1981)
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Retention of marked sensitivity to ( S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-Dihydroquinoxaline-2(1H)-Thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2′,3′-dideoxy-3′-thiacytidine (Lamivudine)
Balzarini, Jan, Pelemans, Heidi, Riess, Gunther, Roesner, Manfred, Winkler, Irvin, De Ckrcq, Erik, Kleim, Jörg-Peter
Published in Biochemical pharmacology (01.03.1998)
Published in Biochemical pharmacology (01.03.1998)
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Journal Article
Hybrid drive section for e.g. passenger car, has main strand implemented in transaxle construction with arrangement of drive transmission at engine distant drive axis and long drive shaft between output shaft of engine and gear input unit
ALBERTI, VOLKER, DIETZE, HOLGER, RAUTENBERG, UWE, DAU, WOLFRAM, ROESNER, MANFRED
Year of Publication 07.02.2008
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Year of Publication 07.02.2008
Patent
Synthesis of two aromatic methylenedioxy-substituted colchicine congeners: elucidation of the structure of cornigerine as 2,3-(methylenedioxy)-2,3-didemethoxycolchicine
Roesner, Manfred, Hsu, Fu-Lian, Brossi, Arnold
Published in Journal of organic chemistry (01.08.1981)
Published in Journal of organic chemistry (01.08.1981)
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Journal Article
SUBSTITUIERTE BENZIMIDAZOLE UND IHRE ANWENDUNG IN DER KREBSBEHANDLUNG
DEPRETS, STEPHANIE, ANGOUILLANT-BONIFACE, ODILE, CLERC, FRANCOIS, DEPATY, ISABELLE, CARREZ, CHANTAL, HAMY, FRANCOIS, ROESNER, MANFRED
Year of Publication 19.02.2009
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Year of Publication 19.02.2009
Patent