Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
Chen, Xiangrong, Ali, Yusuf I, Fisher, Charlotte El, Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B, Williams, Gareth, Walker, Sarah, Booth, Jessica R, Hudson, Jessica Jr, Roe, S Mark, Pearl, Laurence H, Ward, Simon E, Pearl, Frances Mg, Oliver, Antony W
Published in eLife (01.03.2021)
Published in eLife (01.03.2021)
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RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex
Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F., Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J. Mark, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Llorca, Oscar
Published in Nature communications (16.04.2018)
Published in Nature communications (16.04.2018)
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Journal Article
Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex
Pearl, Laurence H, Ali, Maruf M. U, Roe, S. Mark, Vaughan, Cara K, Meyer, Phillipe, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos
Published in Nature (20.04.2006)
Published in Nature (20.04.2006)
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Journal Article
Chaperoned Ubiquitylation—Crystal Structures of the CHIP U Box E3 Ubiquitin Ligase and a CHIP-Ubc13-Uev1a Complex
Zhang, Minghao, Windheim, Mark, Roe, S. Mark, Peggie, Mark, Cohen, Philip, Prodromou, Chrisostomos, Pearl, Laurence H.
Published in Molecular cell (23.11.2005)
Published in Molecular cell (23.11.2005)
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Journal Article
Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1
Pal, Mohinder, Morgan, Marc, Phelps, Sarah E.L., Roe, S. Mark, Parry-Morris, Sarah, Downs, Jessica A., Polier, Sigrun, Pearl, Laurence H., Prodromou, Chrisostomos
Published in Structure (London) (10.06.2014)
Published in Structure (London) (10.06.2014)
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Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein
Parker, James S., Parizotto, Eneida A., Wang, Muhan, Roe, S. Mark, Barford, David
Published in Molecular cell (30.01.2009)
Published in Molecular cell (30.01.2009)
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Journal Article
Regioselective routes to orthogonally-substituted aromatic MIDA boronates
Close, Adam J., Kemmitt, Paul, Roe, S. Mark, Spencer, John
Published in Organic & biomolecular chemistry (01.01.2016)
Published in Organic & biomolecular chemistry (01.01.2016)
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Journal Article
The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90
Blundell, Katie L I M, Pal, Mohinder, Roe, S Mark, Pearl, Laurence H, Prodromou, Chrisostomos
Published in PloS one (09.03.2017)
Published in PloS one (09.03.2017)
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Journal Article
Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition
Morgan, Rhodri M L, Hernández-Ramírez, Laura C, Trivellin, Giampaolo, Zhou, Lihong, Roe, S Mark, Korbonits, Márta, Prodromou, Chrisostomos
Published in PloS one (31.12.2012)
Published in PloS one (31.12.2012)
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Journal Article
The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease
Roe, S Mark, Török, Zsolt, McGown, Andrew, Horváth, Ibolya, Spencer, John, Pázmány, Tamás, Vigh, László, Prodromou, Chrisostomos
Published in Biomolecules (Basel, Switzerland) (28.06.2023)
Published in Biomolecules (Basel, Switzerland) (28.06.2023)
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Journal Article
Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
Meyer, Philippe, Prodromou, Chrisostomos, Hu, Bin, Vaughan, Cara, Roe, S. Mark, Panaretou, Barry, Piper, Peter W., Pearl, Laurence H.
Published in Molecular cell (01.03.2003)
Published in Molecular cell (01.03.2003)
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Journal Article
Palladium(II) complexes of aminothiazole‐based phosphines: Synthesis, structural characterization, density functional theory calculations and catalytic application in heck reaction
Gholivand, Khodayar, Kahnouji, Mohammad, Mark Roe, S., Gholami, Akram, Fadaei, Farzaneh T.
Published in Applied organometallic chemistry (01.11.2017)
Published in Applied organometallic chemistry (01.11.2017)
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Journal Article
Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases
Polychronopoulos, Panagiotis, Magiatis, Prokopios, Skaltsounis, Alexios-Leandros, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Tarricone, Aldo, Musacchio, Andrea, Roe, S. Mark, Pearl, Laurence, Leost, Maryse, Greengard, Paul, Meijer, Laurent
Published in Journal of medicinal chemistry (12.02.2004)
Published in Journal of medicinal chemistry (12.02.2004)
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Journal Article
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery
Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Mark Roe, S, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H
Published in The EMBO journal (11.02.2004)
Published in The EMBO journal (11.02.2004)
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Journal Article
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5
Yang, Jing, Roe, S Mark, Cliff, Matthew J, Williams, Mark A, Ladbury, John E, Cohen, Patricia TW, Barford, David
Published in The EMBO journal (12.01.2005)
Published in The EMBO journal (12.01.2005)
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