Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Cid, José María, Tresadern, Gary, Duvey, Guillaume, Lütjens, Robert, Finn, Terry, Rocher, Jean-Philippe, Poli, Sonia, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Linares, María Lourdes, Andrés, José Ignacio, Alcazar, Jesús, Alonso, José Manuel, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Ahnaou, Abdelah, Drinkenburg, Wilhelmus, Mackie, Claire, Pype, Stefan, Gallacher, David, Trabanco, Andrés A
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents
Rocher, Jean-Philippe, Bonnet, Béatrice, Boléa, Christelle, Lütjens, Robert, Le Poul, Emmanuel, Poli, Sonia, Epping-Jordan, Mark, Bessis, Anne-Sophie, Ludwig, Bernard, Mutel, Vincent
Published in Current topics in medicinal chemistry (01.03.2011)
Published in Current topics in medicinal chemistry (01.03.2011)
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Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson's Disease
Epping-Jordan, Mark P, Girard, Françoise, Bessis, Anne-Sophie, Mutel, Vincent, Boléa, Christelle, Derouet, Francis, Bessif, Abdelhak, Mingard, Brice, Barbier, Stéphanie, Paradis, Justine S, Rocher, Jean-Philippe, Lütjens, Robert, Kalinichev, Mikhail, Poli, Sonia
Published in Cells (Basel, Switzerland) (24.03.2023)
Published in Cells (Basel, Switzerland) (24.03.2023)
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Novel 4-amino-furo[2,3- d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors
Miyazaki, Yasushi, Matsunaga, Shinichiro, Tang, Jun, Maeda, Yutaka, Nakano, Masato, Philippe, Rocher J., Shibahara, Megumi, Liu, Wei, Sato, Hideyuki, Wang, Liping, Nolte, Robert T.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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G-protein activation by a metabotropic glutamate receptor
Seven, Alpay B., Barros-Álvarez, Ximena, de Lapeyrière, Marine, Papasergi-Scott, Makaía M., Robertson, Michael J., Zhang, Chensong, Nwokonko, Robert M., Gao, Yang, Meyerowitz, Justin G., Rocher, Jean-Philippe, Schelshorn, Dominik, Kobilka, Brian K., Mathiesen, Jesper M., Skiniotis, Georgios
Published in Nature (London) (15.07.2021)
Published in Nature (London) (15.07.2021)
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Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target
Parmentier-Batteur, Sophie, Hutson, Peter H., Menzel, Karsten, Uslaner, Jason M., Mattson, Britta A., O'Brien, Julie A., Magliaro, Brian C., Forest, Thomas, Stump, Craig A., Tynebor, Robert M., Anthony, Neville J., Tucker, Thomas J., Zhang, Xu-Fang, Gomez, Robert, Huszar, Sarah L., Lambeng, Nathalie, Fauré, H., Le Poul, Emannuel, Poli, Sonia, Rosahl, Thomas W., Rocher, Jean-Philippe, Hargreaves, Richard, Williams, Theresa M.
Published in Neuropharmacology (01.07.2014)
Published in Neuropharmacology (01.07.2014)
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Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
Cid, Jose María, Duvey, Guillaume, Tresadern, Gary, Nhem, Vanthea, Furnari, Rocco, Cluzeau, Philippe, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Alonso, José Manuel, Linares, María Lourdes, Andrés, José Ignacio, Poli, Sonia M, Lutjens, Robert, Himogai, Hassan, Rocher, Jean-Philippe, Macdonald, Gregor J, Oehlrich, Daniel, Lavreysen, Hilde, Ahnaou, Abdelah, Drinkenburg, Wilhelmus, Mackie, Claire, Trabanco, Andrés A
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core
Duvey, Guillaume, Perry, Benjamin, Le Poul, Emmanuel, Poli, Sonia, Bonnet, Beatrice, Lambeng, Nathalie, Charvin, Delphine, Donovan-Rodrigues, Tansy, Haddouk, Hasnaà, Gagliardi, Stefania, Rocher, Jean-Philippe
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones
Trabanco, Andrés A., Duvey, Guillaume, Cid, José María, Macdonald, Gregor J., Cluzeau, Philippe, Nhem, Vanthea, Furnari, Rocco, Behaj, Nadia, Poulain, Géraldine, Finn, Terry, Lavreysen, Hilde, Poli, Sonia, Raux, Alexandre, Thollon, Yves, Poirier, Nicolas, D’Addona, David, Andrés, José Ignacio, Lutjens, Robert, Poul, Emmanuel Le, Imogai, Hassan, Rocher, Jean-Philippe
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
Cid, Jose María, Duvey, Guillaume, Cluzeau, Philippe, Nhem, Vanthea, Macary, Karim, Raux, Alexandre, Poirier, Nicolas, Muller, Jessica, Boléa, Christelle, Finn, Terry, Poli, Sonia, Epping-Jordan, Mark, Chamelot, Emilie, Derouet, Francis, Girard, Francoise, Macdonald, Gregor J, Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Lavreysen, Hilde, Linares, María Lourdes, Oehlrich, Daniel, Oyarzábal, Julen, Tresadern, Gary, Trabanco, Andrés A, Andrés, Jose Ignacio, Le Poul, Emmanuel, Imogai, Hassan, Lutjens, Robert, Rocher, Jean-Philippe
Published in ACS chemical neuroscience (15.12.2010)
Published in ACS chemical neuroscience (15.12.2010)
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New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones
Trabanco, Andrés A., Duvey, Guillaume, Cid, José María, Macdonald, Gregor J., Cluzeau, Philippe, Nhem, Vanthea, Furnari, Rocco, Behaj, Nadia, Poulain, Géraldine, Finn, Terry, Poli, Sonia, Lavreysen, Hilde, Raux, Alexandre, Thollon, Yves, Poirier, Nicolas, D'Addona, David, Andrés, José Ignacio, Lutjens, Robert, Le Poul, Emmanuel, Imogai, Hassan, Rocher, Jean-Philippe
Published in MedChemComm (01.02.2011)
Published in MedChemComm (01.02.2011)
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Amplitude of Pancreatic Lipase Lid Opening in Solution and Identification of Spin Label Conformational Subensembles by Combining Continuous Wave and Pulsed EPR Spectroscopy and Molecular Dynamics
Ranaldi, Sebastien, Belle, Valérie, Woudstra, Mireille, Bourgeas, Raphael, Guigliarelli, Bruno, Roche, Philippe, Vezin, Hervé, Carrière, Fredéric, Fournel, André
Published in Biochemistry (Easton) (16.03.2010)
Published in Biochemistry (Easton) (16.03.2010)
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