The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic
Hoffmann, Markus, Krüger, Nadine, Schulz, Sebastian, Cossmann, Anne, Rocha, Cheila, Kempf, Amy, Nehlmeier, Inga, Graichen, Luise, Moldenhauer, Anna-Sophie, Winkler, Martin S., Lier, Martin, Dopfer-Jablonka, Alexandra, Jäck, Hans-Martin, Behrens, Georg M.N., Pöhlmann, Stefan
Published in Cell (03.02.2022)
Published in Cell (03.02.2022)
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Journal Article
Omicron subvariant BA.5 efficiently infects lung cells
Hoffmann, Markus, Wong, Lok-Yin Roy, Arora, Prerna, Zhang, Lu, Rocha, Cheila, Odle, Abby, Nehlmeier, Inga, Kempf, Amy, Richter, Anja, Halwe, Nico Joel, Schön, Jacob, Ulrich, Lorenz, Hoffmann, Donata, Beer, Martin, Drosten, Christian, Perlman, Stanley, Pöhlmann, Stefan
Published in Nature communications (13.06.2023)
Published in Nature communications (13.06.2023)
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Journal Article
The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection
Krüger, Nadine, Rocha, Cheila, Runft, Sandra, Krüger, Johannes, Färber, Iris, Armando, Federico, Leitzen, Eva, Brogden, Graham, Gerold, Gisa, Pöhlmann, Stefan, Hoffmann, Markus, Baumgärtner, Wolfgang
Published in International journal of molecular sciences (30.09.2021)
Published in International journal of molecular sciences (30.09.2021)
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Journal Article
The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency
Arora, Prerna, Rocha, Cheila, Kempf, Amy, Nehlmeier, Inga, Graichen, Luise, Winkler, Martin S., Lier, Martin, Schulz, Sebastian, Jäck, Hans-Martin, Cossmann, Anne, Stankov, Metodi V., Behrens, Georg M. N., Pöhlmann, Stefan, Hoffmann, Markus
Published in Cellular & molecular immunology (01.12.2021)
Published in Cellular & molecular immunology (01.12.2021)
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Journal Article
Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models
Kaiser, Franziska K., Hernandez, Mariana Gonzalez, Krüger, Nadine, Englund, Ellinor, Du, Wenjuan, Mykytyn, Anna Z., Raadsen, Mathijs P., Lamers, Mart M., Rodrigues Ianiski, Francine, Shamorkina, Tatiana M., Snijder, Joost, Armando, Federico, Beythien, Georg, Ciurkiewicz, Malgorzata, Schreiner, Tom, Gruber-Dujardin, Eva, Bleyer, Martina, Batura, Olga, Erffmeier, Lena, Hinkel, Rabea, Rocha, Cheila, Mirolo, Monica, Drabek, Dubravka, Bosch, Berend-Jan, Emalfarb, Mark, Valbuena, Noelia, Tchelet, Ronen, Baumgärtner, Wolfgang, Saloheimo, Markku, Pöhlmann, Stefan, Grosveld, Frank, Haagmans, Bart L., Osterhaus, Albert D.M.E.
Published in Nature communications (14.03.2024)
Published in Nature communications (14.03.2024)
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Journal Article
The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant
Arora, Prerna, Zhang, Lu, Rocha, Cheila, Graichen, Luise, Nehlmeier, Inga, Kempf, Amy, Cossmann, Anne, Ramos, Gema Morillas, Baier, Eva, Tampe, Björn, Moerer, Onnen, Dickel, Steffen, Winkler, Martin S, Behrens, Georg M N, Pöhlmann, Stefan, Hoffmann, Markus
Published in International journal of molecular sciences (14.11.2022)
Published in International journal of molecular sciences (14.11.2022)
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Journal Article
Investigations on SARS-CoV-2 Susceptibility of Domestic and Wild Animals Using Primary Cell Culture Models Derived from the Upper and Lower Respiratory Tract
Färber, Iris, Krüger, Johannes, Rocha, Cheila, Armando, Federico, von Köckritz-Blickwede, Maren, Pöhlmann, Stefan, Braun, Armin, Baumgärtner, Wolfgang, Runft, Sandra, Krüger, Nadine
Published in Viruses (16.04.2022)
Published in Viruses (16.04.2022)
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Journal Article
Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19
Krüger, Nadine, Kronenberger, Thales, Xie, Hang, Rocha, Cheila, Pöhlmann, Stefan, Su, Haixia, Xu, Yechun, Laufer, Stefan A., Pillaiyar, Thanigaimalai
Published in Pharmaceuticals (Basel, Switzerland) (28.01.2023)
Published in Pharmaceuticals (Basel, Switzerland) (28.01.2023)
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Journal Article
Host Cell Entry and Neutralization Sensitivity of SARS-CoV-2 Lineages B.1.620 and R.1
Sidarovich, Anzhalika, Krüger, Nadine, Rocha, Cheila, Graichen, Luise, Kempf, Amy, Nehlmeier, Inga, Lier, Martin, Cossmann, Anne, Stankov, Metodi V, Schulz, Sebastian R, Behrens, Georg M N, Jäck, Hans-Martin, Pöhlmann, Stefan, Hoffmann, Markus
Published in Viruses (01.11.2022)
Published in Viruses (01.11.2022)
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Journal Article
Author Correction: Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling
Schoger, Eric, Bleckwedel, Federico, Germena, Giulia, Rocha, Cheila, Tucholla, Petra, Sobitov, Izzatullo, Möbius, Wiebke, Sitte, Maren, Lenz, Christof, Samak, Mostafa, Hinkel, Rabea, Varga, Zoltán V., Giricz, Zoltán, Salinas, Gabriela, Gross, Julia C., Zelarayán, Laura C.
Published in Communications biology (23.05.2024)
Published in Communications biology (23.05.2024)
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Journal Article
Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling
Schoger, Eric, Bleckwedel, Federico, Germena, Giulia, Rocha, Cheila, Tucholla, Petra, Sobitov, Izzatullo, Möbius, Wiebke, Sitte, Maren, Lenz, Christof, Samak, Mostafa, Hinkel, Rabea, Varga, Zoltán V., Giricz, Zoltán, Salinas, Gabriela, Gross, Julia C., Zelarayán, Laura C.
Published in Communications biology (21.01.2023)
Published in Communications biology (21.01.2023)
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Journal Article
Potent and Broadly Reactive HIV-2 Neutralizing Antibodies Elicited by a Vaccinia Virus Vector Prime-C2V3C3 Polypeptide Boost Immunization Strategy
MARCELINO, José Maria, BORREGO, Pedro, ROCHA, Cheila, BARROSO, Helena, QUINTAS, Alexandre, NOVO, Carlos, TAVEIRA, Nuno
Published in Journal of Virology (01.12.2010)
Published in Journal of Virology (01.12.2010)
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Journal Article
Antiretroviral Drug Resistance Surveillance among Treatment-Naive Human Immunodeficiency Virus Type 1-Infected Individuals in Angola: Evidence for Low Level of Transmitted Drug Resistance
Bártolo, Inês, Rocha, Cheila, Bartolomeu, José, Gama, António, Fonseca, Marlene, Mendes, Ana, Cristina, Filipa, Thamm, Sven, Epalanga, Marta, Silva, Patrícia Cavaco, Taveira, Nuno
Published in Antimicrobial Agents and Chemotherapy (01.07.2009)
Published in Antimicrobial Agents and Chemotherapy (01.07.2009)
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The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients
Borrego, Pedro, Marcelino, José Maria, Rocha, Cheila, Doroana, Manuela, Antunes, Francisco, Maltez, Fernando, Gomes, Perpétua, Novo, Carlos, Barroso, Helena, Taveira, Nuno
Published in Retrovirology (08.09.2008)
Published in Retrovirology (08.09.2008)
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Journal Article
Comparable neutralisation evasion of SARS-CoV-2 omicron subvariants BA.1, BA.2, and BA.3
Arora, Prerna, Zhang, Lu, Rocha, Cheila, Sidarovich, Anzhalika, Kempf, Amy, Schulz, Sebastian, Cossmann, Anne, Manger, Bernhard, Baier, Eva, Tampe, Björn, Moerer, Onnen, Dickel, Steffen, Dopfer-Jablonka, Alexandra, Jäck, Hans-Martin, Behrens, Georg M N, Winkler, Martin S, Pöhlmann, Stefan, Hoffmann, Markus
Published in The Lancet infectious diseases (01.06.2022)
Published in The Lancet infectious diseases (01.06.2022)
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Journal Article
SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies
Arora, Prerna, Zhang, Lu, Krüger, Nadine, Rocha, Cheila, Sidarovich, Anzhalika, Schulz, Sebastian, Kempf, Amy, Graichen, Luise, Moldenhauer, Anna-Sophie, Cossmann, Anne, Dopfer-Jablonka, Alexandra, Behrens, Georg M.N., Jäck, Hans-Martin, Pöhlmann, Stefan, Hoffmann, Markus
Published in Cell Host & Microbe (10.08.2022)
Published in Cell Host & Microbe (10.08.2022)
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Abstract MP217: Nuclease-deficient Cas9 Transcription Factors Restore Krueppel-like Factor 15 Expression In Stressed Mouse And Human Cardiomyocytes
Schoger, Eric, Rosa, Kim, Rocha, Cheila, Jassyk, Mareike, Doroudgar, Shirin, Mueller, Oliver, Cyganek, Lukas, Zimmermann, Wolfram H, Zelarayan, Laura C
Published in Circulation research (03.09.2021)
Published in Circulation research (03.09.2021)
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Journal Article
Small-Molecule Thioesters as SARS-CoV‑2 Main Protease Inhibitors: Enzyme Inhibition, Structure–Activity Relationships, Antiviral Activity, and X‑ray Structure Determination
Pillaiyar, Thanigaimalai, Flury, Philipp, Krüger, Nadine, Su, Haixia, Schäkel, Laura, Barbosa Da Silva, Elany, Eppler, Olga, Kronenberger, Thales, Nie, Tianqing, Luedtke, Stephanie, Rocha, Cheila, Sylvester, Katharina, Petry, Marvin R.I., McKerrow, James H., Poso, Antti, Pöhlmann, Stefan, Gütschow, Michael, O’Donoghue, Anthony J., Xu, Yechun, Müller, Christa E., Laufer, Stefan A.
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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Abstract 498: Krueppel-like Factor 15 Modulation: A Crispr-based Re-establishment of Homeostatic Transcription in Diseased Mouse and Human Cardiomyocytes
Schoger, Eric, Iyer, Lavanya M, Noack, Claudia, Rocha, Cheila, Jassyk, Mareike, Shomroni, Orr, Salinas, Gabriela, Zelarayan, Laura C
Published in Circulation research (31.07.2020)
Published in Circulation research (31.07.2020)
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Journal Article
Discovery of Polyphenolic Natural Products as SARS-CoV-2 M pro Inhibitors for COVID-19
Krüger, Nadine, Kronenberger, Thales, Xie, Hang, Rocha, Cheila, Pöhlmann, Stefan, Su, Haixia, Xu, Yechun, Laufer, Stefan A, Pillaiyar, Thanigaimalai
Published in Pharmaceuticals (Basel, Switzerland) (28.01.2023)
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Published in Pharmaceuticals (Basel, Switzerland) (28.01.2023)
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