Targeting the phosphoinositide 3-kinase pathway in cancer
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Published in Nature reviews. Drug discovery (01.08.2009)
Published in Nature reviews. Drug discovery (01.08.2009)
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The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
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Published in Current biology (06.10.2014)
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KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
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Published in Cell (03.07.2014)
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PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis
Ilic, Nina, Utermark, Tamara, Widlund, Hans R, Roberts, Thomas M
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
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PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer
Ding, Liya, Kim, Hye-Jung, Wang, Qiwei, Kearns, Michael, Jiang, Tao, Ohlson, Carolynn E., Li, Ben B., Xie, Shaozhen, Liu, Joyce F., Stover, Elizabeth H., Howitt, Brooke E., Bronson, Roderick T., Lazo, Suzan, Roberts, Thomas M., Freeman, Gordon J., Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Zhao, Jean J.
Published in Cell reports (Cambridge) (11.12.2018)
Published in Cell reports (Cambridge) (11.12.2018)
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The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
Wang, Haizhen, Nicolay, Brandon N., Chick, Joel M., Gao, Xueliang, Geng, Yan, Ren, Hong, Gao, Hui, Yang, Guizhi, Williams, Juliet A., Suski, Jan M., Keibler, Mark A., Sicinska, Ewa, Gerdemann, Ulrike, Haining, W. Nicholas, Roberts, Thomas M., Polyak, Kornelia, Gygi, Steven P., Dyson, Nicholas J., Sicinski, Piotr
Published in Nature (London) (15.06.2017)
Published in Nature (London) (15.06.2017)
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STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
Wang, Qiwei, Bergholz, Johann S., Ding, Liya, Lin, Ziying, Kabraji, Sheheryar K., Hughes, Melissa E., He, Xiadi, Xie, Shaozhen, Jiang, Tao, Wang, Weihua, Zoeller, Jason J., Kim, Hye-Jung, Roberts, Thomas M., Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Dillon, Deborah A., Winer, Eric P., Lin, Nancy U., Zhao, Jean J.
Published in Nature communications (31.05.2022)
Published in Nature communications (31.05.2022)
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An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide)
Korpal, Manav, Korn, Joshua M, Gao, Xueliang, Rakiec, Daniel P, Ruddy, David A, Doshi, Shivang, Yuan, Jing, Kovats, Steve G, Kim, Sunkyu, Cooke, Vesselina G, Monahan, John E, Stegmeier, Frank, Roberts, Thomas M, Sellers, William R, Zhou, Wenlai, Zhu, Ping
Published in Cancer discovery (01.09.2013)
Published in Cancer discovery (01.09.2013)
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Combination of KRAS gene silencing and PI3K inhibition for ovarian cancer treatment
Kim, Min Ju, Lee, So Jin, Ryu, Ju Hee, Kim, Sun Hwa, Kwon, Ick Chan, Roberts, Thomas M.
Published in Journal of controlled release (01.02.2020)
Published in Journal of controlled release (01.02.2020)
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PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer
Spangle, Jennifer M., Dreijerink, Koen M., Groner, Anna C., Cheng, Hailing, Ohlson, Carolynn E., Reyes, Jaime, Lin, Charles Y., Bradner, James, Zhao, Jean J., Roberts, Thomas M., Brown, Myles
Published in Cell reports (Cambridge) (21.06.2016)
Published in Cell reports (Cambridge) (21.06.2016)
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PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
Schmit, Fabienne, Utermark, Tamara, Zheng, Sen, Wang, Qi, Von, Thanh, Roberts, Thomas M., Zhao, Jean J.
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2014)
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Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases
Ni, Jing, Ramkissoon, Shakti H, Xie, Shaozhen, Goel, Shom, Stover, Daniel G, Guo, Hanbing, Luu, Victor, Marco, Eugenio, Ramkissoon, Lori A, Kang, Yun Jee, Hayashi, Marika, Nguyen, Quang-De, Ligon, Azra H, Du, Rose, Claus, Elizabeth B, Alexander, Brian M, Yuan, Guo-Cheng, Wang, Zhigang C, Iglehart, J Dirk, Krop, Ian E, Roberts, Thomas M, Winer, Eric P, Lin, Nancy U, Ligon, Keith L, Zhao, Jean J
Published in Nature medicine (01.07.2016)
Published in Nature medicine (01.07.2016)
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The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
Chang, Hyeyoun, Cai, Zhenying, Roberts, Thomas M
Published in Biomolecules (Basel, Switzerland) (07.11.2019)
Published in Biomolecules (Basel, Switzerland) (07.11.2019)
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Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer
Wang, Dong, Wang, Min, Jiang, Nan, Zhang, Yuan, Bian, Xing, Wang, Xiaoqing, Roberts, Thomas M, Zhao, Jean J, Liu, Pixu, Cheng, Hailing
Published in Oncotarget (15.03.2016)
Published in Oncotarget (15.03.2016)
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The identification of zebrafish mutants showing alterations in senescence-associated biomarkers
Kishi, Shuji, Bayliss, Peter E, Uchiyama, Junzo, Koshimizu, Eriko, Qi, Jie, Nanjappa, Purushothama, Imamura, Shintaro, Islam, Asiful, Neuberg, Donna, Amsterdam, Adam, Roberts, Thomas M
Published in PLoS genetics (01.08.2008)
Published in PLoS genetics (01.08.2008)
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The Oncogenic Properties of Mutant p110α and p110β Phosphatidylinositol 3-Kinases in Human Mammary Epithelial Cells
Jean J. Zhao, Zhenning Liu, Wang, Li, Shin, Eyoung, Massimo F. Loda, Roberts, Thomas M., Cantley, Lewis C.
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2005)
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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer
Ding, Liya, Wang, Qiwei, Martincuks, Antons, Kearns, Michael J, Jiang, Tao, Lin, Ziying, Cheng, Xin, Qian, Changli, Xie, Shaozhen, Kim, Hye-Jung, Launonen, Inga-Maria, Färkkilä, Anniina, Roberts, Thomas M, Freeman, Gordon J, Liu, Joyce F, Konstantinopoulos, Panagiotis A, Matulonis, Ursula, Yu, Hua, Zhao, Jean J
Published in Journal for immunotherapy of cancer (01.01.2023)
Published in Journal for immunotherapy of cancer (01.01.2023)
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The role of the PIK3CA gene in the development and aging of the brain
Xie, Shaozhen, Ni, Jing, Guo, Hanbing, Luu, Victor, Wang, Yanzhi, Zhao, Jean J., Roberts, Thomas M.
Published in Scientific reports (11.01.2021)
Published in Scientific reports (11.01.2021)
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RNAi-Based Approaches for Pancreatic Cancer Therapy
Kim, Min Ju, Chang, Hyeyoun, Nam, Gihoon, Ko, Youngji, Kim, Sun Hwa, Roberts, Thomas M., Ryu, Ju Hee
Published in Pharmaceutics (08.10.2021)
Published in Pharmaceutics (08.10.2021)
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CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells
Zhang, Jing, Gao, Xueliang, Schmit, Fabienne, Adelmant, Guillaume, Eck, Michael J., Marto, Jarrod A., Zhao, Jean J., Roberts, Thomas M.
Published in Cell reports (Cambridge) (18.07.2017)
Published in Cell reports (Cambridge) (18.07.2017)
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