Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS‐790052 in Humans: In Vitro and In Vivo Correlations
Fridell, Robert A., Wang, Chunfu, Sun, Jin‐Hua, O'Boyle, Donald R., Nower, Peter, Valera, Lourdes, Qiu, Dike, Roberts, Susan, Huang, Xin, Kienzle, Bernadette, Bifano, Marc, Nettles, Richard E., Gao, Min
Published in Hepatology (Baltimore, Md.) (01.12.2011)
Published in Hepatology (Baltimore, Md.) (01.12.2011)
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Persistence of Resistant Variants in Hepatitis C Virus-Infected Patients Treated with the NS5A Replication Complex Inhibitor Daclatasvir
CHUNFU WANG, SUN, Jin-Hua, O'BOYLE, Donald R, NOWER, Peter, VALERA, Lourdes, ROBERTS, Susan, FRIDELL, Robert A, MIN GAO
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
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Comparison of daclatasvir resistance barriers on NS5A from hepatitis C virus genotypes 1 to 6: implications for cross-genotype activity
Wang, Chunfu, Jia, Lingling, O'Boyle, 2nd, Donald R, Sun, Jin-Hua, Rigat, Karen, Valera, Lourdes, Nower, Peter, Huang, Xin, Kienzle, Bernadette, Roberts, Susan, Gao, Min, Fridell, Robert A
Published in Antimicrobial agents and chemotherapy (01.09.2014)
Published in Antimicrobial agents and chemotherapy (01.09.2014)
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In Vitro Activity of Daclatasvir on Hepatitis C Virus Genotype 3 NS5A
CHUNFU WANG, VALERA, Lourdes, LINGLING JIA, KIRK, Melissa J, MIN GAO, FRIDELL, Robert A
Published in Antimicrobial Agents and Chemotherapy (01.01.2013)
Published in Antimicrobial Agents and Chemotherapy (01.01.2013)
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Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir
Belema, Makonen, Nguyen, Van N., Bachand, Carol, Deon, Dan H., Goodrich, Jason T., James, Clint A., Lavoie, Rico, Lopez, Omar D., Martel, Alain, Romine, Jeffrey L., Ruediger, Edward H., Snyder, Lawrence B., Laurent, Denis R. St, Yang, Fukang, Zhu, Juliang, Wong, Henry S., Langley, David R., Adams, Stephen P., Cantor, Glenn H., Chimalakonda, Anjaneya, Fura, Aberra, Johnson, Benjamin M., Knipe, Jay O., Parker, Dawn D., Santone, Kenneth S., Fridell, Robert A., Lemm, Julie A., O’Boyle, Donald R., Colonno, Richard J., Gao, Min, Meanwell, Nicholas A., Hamann, Lawrence G.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Hepatitis C Virus RNA Elimination and Development of Resistance in Replicon Cells Treated with BMS-790052
Wang, Chunfu, Huang, Haichang, Valera, Lourdes, Sun, Jin-Hua, O'Boyle, Donald R., II, Nower, Peter T, Jia, Lingling, Qiu, Dike, Huang, Xin, Altaf, Aneela, Gao, Min, Fridell, Robert A
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
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Intragenic Complementation of Hepatitis C Virus NS5A RNA Replication-Defective Alleles
Fridell, Robert A, Valera, Lourdes, Qiu, Dike, Kirk, Melissa J, Wang, Chunfu, Gao, Min
Published in Journal of Virology (01.02.2013)
Published in Journal of Virology (01.02.2013)
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Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5a replication complex inhibitor, BMS-790052
Sun, Jin-Hua, O'Boyle II, Donald R., Zhang, Yan, Wang, Chunfu, Nower, Peter, Valera, Lourdes, Roberts, Susan, Nettles, Richard E., Fridell, Robert A., Gao, Min
Published in Hepatology (Baltimore, Md.) (01.06.2012)
Published in Hepatology (Baltimore, Md.) (01.06.2012)
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In Vitro Activity of BMS-790052 on Hepatitis C Virus Genotype 4 NS5A
Wang, Chunfu, Jia, Lingling, Huang, Haichang, Qiu, Dike, Valera, Lourdes, Huang, Xin, Sun, Jin-Hua, Nower, Peter T, O'Boyle, 2nd, Donald R, Gao, Min, Fridell, Robert A
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
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effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization
Qiu, Dike, Lemm, Julie A, O’Boyle, Donald R., II, Sun, Jin-Hua, Nower, Peter T, Nguyen, Van, Hamann, Lawrence G, Snyder, Lawrence B, Deon, Daniel H, Ruediger, Edward, Meanwell, Nicholas A, Belema, Makonen, Gao, Min, Fridell, Robert A
Published in Journal of general virology (01.11.2011)
Published in Journal of general virology (01.11.2011)
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Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase
Ding, Min, He, Feng, Hudyma, Thomas W., Zheng, Xiaofan, Poss, Michael A., Kadow, John F., Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert A., Lemm, Julie A., Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore A., Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Antiviral Properties of HIV-1 Capsid Inhibitor GSK878
Wang, Chunfu, Huang, Haichang, Mallon, Kirsten, Valera, Lourdes, Parcella, Kyle, Cockett, Mark I, Kadow, John F, Gillis, Eric P, Krystal, Mark, Fridell, Robert A
Published in Antimicrobial agents and chemotherapy (17.05.2023)
Published in Antimicrobial agents and chemotherapy (17.05.2023)
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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
Meanwell, Nicholas A, Gao, Min, Nettles, Richard E, Belema, Makonen, Snyder, Lawrence B, Nguyen, Van N, Fridell, Robert A, Serrano-Wu, Michael H, Langley, David R, Sun, Jin-Hua, O’Boyle II, Donald R, Lemm, Julie A, Wang, Chunfu, Knipe, Jay O, Chien, Caly, Colonno, Richard J, Grasela, Dennis M, Hamann, Lawrence G
Published in Nature (London) (06.05.2010)
Published in Nature (London) (06.05.2010)
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The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration
Marquis, Kaitlin A, Everett, John, Cantu, Adrian, McFarland, Alexander, Sherrill-Mix, Scott, Krystal, Mark, Parcella, Kyle, Gillis, Eric, Fridell, Robert A, Bushman, Frederic D
Published in AIDS research and human retroviruses (01.02.2024)
Published in AIDS research and human retroviruses (01.02.2024)
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Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors
Belema, Makonen, Lopez, Omar D., Bender, John A., Romine, Jeffrey L., St. Laurent, Denis R., Langley, David R., Lemm, Julie A., O’Boyle, Donald R., Sun, Jin-Hua, Wang, Chunfu, Fridell, Robert A., Meanwell, Nicholas A.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A
Sun, Jin-Hua, O’Boyle II, Donald R., Fridell, Robert A., Langley, David R., Wang, Chunfu, Roberts, Susan B., Nower, Peter, Johnson, Benjamin M., Moulin, Frederic, Nophsker, Michelle J., Wang, Ying-Kai, Liu, Mengping, Rigat, Karen, Tu, Yong, Hewawasam, Piyasena, Kadow, John, Meanwell, Nicholas A., Cockett, Mark, Lemm, Julie A., Kramer, Melissa, Belema, Makonen, Gao, Min
Published in Nature (London) (12.11.2015)
Published in Nature (London) (12.11.2015)
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Characterizations of HCV NS5A replication complex inhibitors
O'Boyle II, Donald R, Sun, Jin-Hua, Nower, Peter T, Lemm, Julie A, Fridell, Robert A, Wang, Chunfu, Romine, Jeffrey L, Belema, Makonen, Nguyen, Van N, Laurent, Denis R. St, Serrano-Wu, Michael, Snyder, Lawrence B, Meanwell, Nicholas A, Langley, David R, Gao, Min
Published in Virology (New York, N.Y.) (01.09.2013)
Published in Virology (New York, N.Y.) (01.09.2013)
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