Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma
Cloughesy, Timothy F, Landolfi, Joseph, Hogan, Daniel J, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Elder, J Bradley, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh Leia, Piccioni, David, Walbert, Tobias, Chu, Alice, Das, Asha, Diago, Oscar R, Gammon, Dawn, Gruber, Harry E, Hanna, Michelle, Jolly, Douglas J, Kasahara, Noriyuki, McCarthy, David, Mitchell, Leah, Ostertag, Derek, Robbins, Joan M, Rodriguez-Aguirre, Maria, Vogelbaum, Michael A
Published in Science translational medicine (01.06.2016)
Published in Science translational medicine (01.06.2016)
Get more information
Journal Article
Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity
Hiraoka, Kei, Inagaki, Akihito, Kato, Yuki, Huang, Tiffany T, Mitchell, Leah A, Kamijima, Shuichi, Takahashi, Masamichi, Matsumoto, Hiroshi, Hacke, Katrin, Kruse, Carol A, Ostertag, Derek, Robbins, Joan M, Gruber, Harry E, Jolly, Douglas J, Kasahara, Noriyuki
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Get full text
Journal Article
Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model
Huang, Tiffany T, Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M, Espinoza, Fernando Lopez, Martin, Bryan, Ibañez, Carlos E, Kasahara, Noriyuki, Gruber, Harry E, Pertschuk, Daniel, Jolly, Douglas J, Robbins, Joan M
Published in Human gene therapy (01.02.2015)
Published in Human gene therapy (01.02.2015)
Get more information
Journal Article
A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models
Yagiz, Kader, Rodriguez-Aguirre, Maria E., Lopez Espinoza, Fernando, Montellano, Tiffany T., Mendoza, Daniel, Mitchell, Leah A., Ibanez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Molecular therapy. Oncolytics (30.03.2018)
Published in Molecular therapy. Oncolytics (30.03.2018)
Get full text
Journal Article
Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model
Mitchell, Leah A, Lopez Espinoza, Fernando, Mendoza, Daniel, Kato, Yuki, Inagaki, Akihito, Hiraoka, Kei, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Get full text
Journal Article
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector
Ostertag, Derek, Amundson, Karin K, Lopez Espinoza, Fernando, Martin, Bryan, Buckley, Taylor, Galvão da Silva, Ana Paula, Lin, Amy H, Valenta, David T, Perez, Omar D, Ibañez, Carlos E, Chen, Ching-I, Pettersson, Pär L, Burnett, Ryan, Daublebsky, Veronika, Hlavaty, Juraj, Gunzburg, Walter, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2012)
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2012)
Get full text
Journal Article
Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models
Yagiz, Kader, Huang, Tiffany T, Lopez Espinoza, Fernando, Mendoza, Daniel, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
Get full text
Journal Article
Retroviral replicating vectors in cancer
Logg, Christopher R, Robbins, Joan M, Jolly, Douglas J, Gruber, Harry E, Kasahara, Noriyuki
Published in Methods in enzymology (2012)
Published in Methods in enzymology (2012)
Get more information
Journal Article
MIC-1, a Novel Macrophage Inhibitory Cytokine, is a Divergent Member of the TGF-β superfamily
Bootcov, Michelle R., Bauskin, Asne R., Valenzuela, Stella M., Moore, Anthony G., Bansal, Mohinder, He, Xiao Yan, Zhang, Hong Ping, Donnellan, Melissa, Mahler, Stephen, Pryor, Kimberley, Walsh, Bradley J., Nicholson, Richard C., Fairlie, W. Douglas, Por, Suzanne B., Robbins, Joan M., Breit, Samuel N.
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.1997)
Get full text
Journal Article
Identification of Id4 as a Regulator of BRCA1 Expression by Using a Ribozyme-Library-Based Inverse Genomics Approach
Beger, Carmela, Pierce, Leigh N., Krüger, Martin, Marcusson, Eric G., Robbins, Joan M., Welcsh, Piri, Welch, Peter J., Welte, Karl, King, Mary-Claire, Barber, Jack R., Wong-Staal, Flossie
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2001)
Get full text
Journal Article
Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene
Lin, Amy H, Liu, Yanzheng, Burrascano, Cynthia, Cunanan, Kathrina, Logg, Christopher R, Robbins, Joan M, Kasahara, Noriyuki, Gruber, Harry, Ibañez, Carlos, Jolly, Douglas J
Published in Human gene therapy. Part B. Methods (01.04.2016)
Published in Human gene therapy. Part B. Methods (01.04.2016)
Get more information
Journal Article
Molecular Cloning and Expression of a Chloride Ion Channel of Cell Nuclei
Valenzuela, S M, Martin, D K, Por, S B, Robbins, J M, Warton, K, Bootcov, M R, Schofield, P R, Campbell, T J, Breit, S N
Published in The Journal of biological chemistry (09.05.1997)
Published in The Journal of biological chemistry (09.05.1997)
Get full text
Journal Article
A novel functional genomics approach identifies mTERT as a suppressor of fibroblast transformation
Li, Q X, Robbins, J M, Welch, P J, Wong-Staal, F, Barber, J R
Published in Nucleic acids research (01.07.2000)
Published in Nucleic acids research (01.07.2000)
Get full text
Journal Article
Abstract 6713: Oncolytic adenoviruses expressing immune modulators enhance tumor cell killing in human cancer 3D microtumor models
Springgay, Laura K., Strauwald, Amy M., Ewald, Brett, Robbins, Joan M., Chan, Winnie M.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Human alloreactive CTL interactions with gliomas and with those having upregulated HLA expression from exogenous IFN-gamma or IFN-gamma gene modification
Read, Susana B, Kulprathipanja, Nisha V, Gomez, German G, Paul, David B, Winston, Ken R, Robbins, Joan M, Kruse, Carol A
Published in Journal of interferon & cytokine research (01.07.2003)
Published in Journal of interferon & cytokine research (01.07.2003)
Get full text
Journal Article
Phase I trial of interferon-gamma (IFN-gamma) retroviral vector administered intratumorally to patients with metastatic melanoma
Nemunaitis, J, Fong, T, Robbins, J M, Edelman, G, Edwards, W, Paulson, R S, Bruce, J, Ognoskie, N, Wynne, D, Pike, M, Kowal, K, Merritt, J, Ando, D
Published in Cancer gene therapy (01.07.1999)
Published in Cancer gene therapy (01.07.1999)
Get full text
Journal Article
Abstract 3212: Combining Toca 511 and 5-fluorocytosine with PD-1 or CTLA-4 antibody significantly reduces tumor burden compared to either checkpoint inhibitor alone or in combination in a subcutaneous mouse glioma model
Mitchell, Leah, Lopez Espinoza, Fernando, Yagiz, Kader, Mendoza, Daniel, Rodriguez-Aguirre, Maria, Mitchell, Sean, Jolly, Douglas J, Robbins, Joan M
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
Abstract 3212: Combining Toca 511 and 5-fluorocytosine with αPD-1 or αCTLA-4 antibody significantly reduces tumor burden compared to either checkpoint inhibitor alone or in combination in a subcutaneous mouse glioma model
Mitchell, Leah, Lopez Espinoza, Fernando, Yagiz, Kader, Mendoza, Daniel, Rodriguez-Aguirre, Maria, Mitchell, Sean, Jolly, Douglas J., Robbins, Joan M.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article