GDC-0449—A potent inhibitor of the hedgehog pathway
Robarge, Kirk D., Brunton, Shirley A., Castanedo, Georgette M., Cui, Yong, Dina, Michael S., Goldsmith, Richard, Gould, Stephen E., Guichert, Oivin, Gunzner, Janet L., Halladay, Jason, Jia, Wei, Khojasteh, Cyrus, Koehler, Michael F.T., Kotkow, Karen, La, Hank, LaLonde, Rebecca L., Lau, Kevin, Lee, Leslie, Marshall, Derek, Marsters, James C., Murray, Lesley J., Qian, Changgeng, Rubin, Lee L., Salphati, Laurent, Stanley, Mark S., Stibbard, John H.A., Sutherlin, Daniel P., Ubhayaker, Savita, Wang, Shumei, Wong, Susan, Xie, Minli
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Journal Article
Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479
Robarge, Kirk D., Lee, Wendy, Eigenbrot, Charles, Ultsch, Mark, Wiesmann, Christian, Heald, Robert, Price, Steve, Hewitt, Joanne, Jackson, Philip, Savy, Pascal, Burton, Brenda, Choo, Edna F., Pang, Jodie, Boggs, Jason, Yang, April, Yang, Xioaye, Baumgardner, Matthew
Published in Bioorganic & medicinal chemistry letters (01.10.2014)
Published in Bioorganic & medicinal chemistry letters (01.10.2014)
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A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors
Lee, Wendy, Ortwine, Daniel F., Bergeron, Philippe, Lau, Kevin, Lin, Lichuan, Malek, Shiva, Nonomiya, Jim, Pei, Zhonghua, Robarge, Kirk D., Schmidt, Stephen, Sideris, Steve, Lyssikatos, Joseph P.
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
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Potent, Selective, and Orally Bioavailable Inhibitors of Mammalian Target of Rapamycin (mTOR) Kinase Based on a Quaternary Substituted Dihydrofuropyrimidine
Cohen, Frederick, Bergeron, Philippe, Blackwood, Elizabeth, Bowman, Krista K, Chen, Huifen, DiPasquale, Antonio G, Epler, Jennifer A, Koehler, Michael F. T, Lau, Kevin, Lewis, Cristina, Liu, Lichuan, Ly, Cuong Q, Malek, Shiva, Nonomiya, Jim, Ortwine, Daniel F, Pei, Zhonghua, Robarge, Kirk D, Sideris, Steve, Trinh, Lan, Truong, Tom, Wu, Jiansheng, Zhao, Xianrui, Lyssikatos, Joseph P
Published in Journal of medicinal chemistry (12.05.2011)
Published in Journal of medicinal chemistry (12.05.2011)
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Journal Article
Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway
Castanedo, Georgette M., Wang, Shumei, Robarge, Kirk D., Blackwood, Elizabeth, Burdick, Daniel, Chang, Christine, Dijkgraaf, Gerrit J.P., Gould, Stephen, Gunzner, Janet, Guichert, Oivin, Halladay, Jason, Khojasteh, Cyrus, Lee, Leslie, Marsters, James C., Murray, Lesley, Peterson, David, Plise, Emile, Salphati, Laurent, de Sauvage, Frederic J., Wong, Susan, Sutherlin, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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From Peptide to Non-Peptide. 3. Atropisomeric GPIIbIIIa Antagonists Containing the 3,4-Dihydro-1H-1,4-benzodiazepine-2,5-dione Nucleus
Blackburn, Brent K, Lee, Arthur, Baier, Mark, Kohl, Benjamin, Olivero, Alan G, Matamoros, Regina, Robarge, Kirk D, McDowell, Robert S
Published in Journal of medicinal chemistry (28.02.1997)
Published in Journal of medicinal chemistry (28.02.1997)
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Journal Article
IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
ROBARGE KIRK D, TSUI VICKIE HSAIO WEI, MAGNUSON STEVEN R, LAI YINGJIE, ZHANG BIRONG, LIANG JUN
Year of Publication 02.07.2014
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Year of Publication 02.07.2014
Patent
N-9-SUBSTITUTED PURINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
ROBARGE KIRK D, LEE WENDY, LYSSIKATOS JOSEPH P, LAU KEVIN HON LUEN, PEI ZHONGHUA
Year of Publication 25.09.2012
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Year of Publication 25.09.2012
Patent
From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold
McDowell, Robert S, Blackburn, Brent K, Gadek, Thomas R, McGee, Lawrence R, Rawson, Thomas, Reynolds, Mark E, Robarge, Kirk D, Somers, Todd C, Thorsett, Eugene D
Published in Journal of the American Chemical Society (01.06.1994)
Published in Journal of the American Chemical Society (01.06.1994)
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Journal Article
JANUS KINASE INHIBITOR COMPOUNDS AND METHODS
ROBARGE KIRK D, MAGNUSON STEVEN R, LAI YINGJIE, GOODACRE SIMON CHARLES, ZHANG BIRONG, STANLEY MARK S, TSUI VICKIE HSIAO WEI, LIANG JUN, WILLIAMS KAREN, ZHOU AIHE
Year of Publication 12.04.2012
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Year of Publication 12.04.2012
Patent
Mono-N-alkylation of anthranilamides via quinazolinones. An efficient synthesis of G5598, a benzodiazepine dione gpIIbIIIa antagonist
Webb, Robert R, Barker, Peter L, Baier, Mark, Reynolds, Mark E, Robarge, Kirk D, Blackburn, Brent K, Tischler, Maureen H, Weese, Kenneth J
Published in Tetrahedron letters (04.04.1994)
Published in Tetrahedron letters (04.04.1994)
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Journal Article
Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]
Robarge, Kirk D., Brunton, Shirley A., Castanedo, Georgette M., Cui, Yong, Dina, Michael S., Goldsmith, Richard, Gould, Stephen E., Guichert, Oivin, Gunzner, Janet L., Halladay, Jason, Jia, Wei, Khojasteh, Cyrus, Koehler, Michael F.T., Kotkow, Karen, La, Hank, LaLonde, Rebecca L., Lau, Kevin, Lee, Leslie, Marshall, Derek, Marsters, James C., Murray, Lesley J., Qian, Changgeng, Rubin, Lee L., Salphati, Laurent, Stanley, Mark S., Stibbard, John H.A., Sutherlin, Daniel P., Ubhayaker, Savita, Wang, Shumei, Wong, Susan, Xie, Minli
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
BISAMIDHÆMMERE AF HEDGEHOG-SIGNALERING
SUTHERLIN, Daniel P, ROBARGE, Kirk D, OLIVERO, Alan G, GOLDSMITH, Richard A
Year of Publication 19.12.2016
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Year of Publication 19.12.2016
Patent
BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING
SUTHERLIN, DANIEL P, GOLDSMITH, RICHARD A, ROBARGE, KIRK D, OLIVERO, ALAN G
Year of Publication 02.11.2016
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Year of Publication 02.11.2016
Patent
Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists
Robarge, Kirk D., Dina, Michael S., Somers, Todd C., Lee, Arthur, Rawson, Thomas E., Olivero, Alan G., Tischler, Maureen H., Webb, Robert R., Weese, Kenneth J., Aliagas, Ignacio, Blackburn, Brent K.
Published in Bioorganic & medicinal chemistry (01.12.1998)
Published in Bioorganic & medicinal chemistry (01.12.1998)
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