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Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis
Wright, R. Scott, Ray, Kausik K., Raal, Frederick J., Kallend, David G., Jaros, Mark, Koenig, Wolfgang, Leiter, Lawrence A., Landmesser, Ulf, Schwartz, Gregory G., Friedman, Andrew, Wijngaard, Peter L.J., Garcia Conde, Lorena, Kastelein, John J.P.
Published in Journal of the American College of Cardiology (09.03.2021)
Published in Journal of the American College of Cardiology (09.03.2021)
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Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
Fitzgerald, Kevin, Frank-Kamenetsky, Maria, Shulga-Morskaya, Svetlana, Liebow, Abigail, Bettencourt, Brian R, Sutherland, Jessica E, Hutabarat, Renta M, Clausen, Valerie A, Karsten, Verena, Cehelsky, Jeffrey, Nochur, Saraswathy V, Kotelianski, Victor, Horton, Jay, Mant, Timothy, Chiesa, Joseph, Ritter, James, Munisamy, Malathy, Vaishnaw, Akshay K, Gollob, Jared A, Simon, Amy
Published in The Lancet (British edition) (04.01.2014)
Published in The Lancet (British edition) (04.01.2014)
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Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
Zimmermann, Tracy S., Karsten, Verena, Chan, Amy, Chiesa, Joseph, Boyce, Malcolm, Bettencourt, Brian R., Hutabarat, Renta, Nochur, Saraswathy, Vaishnaw, Akshay, Gollob, Jared
Published in Molecular therapy (04.01.2017)
Published in Molecular therapy (04.01.2017)
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Inclisiran Lowers LDL-C and PCSK9 Irrespective of Diabetes Status: The ORION-1 Randomized Clinical Trial
Leiter, Lawrence A., Teoh, Hwee, Kallend, David, Wright, R. Scott, Landmesser, Ulf, Wijngaard, Peter L.J., Kastelein, John J.P., Ray, Kausik K.
Published in Diabetes care (01.01.2019)
Published in Diabetes care (01.01.2019)
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Effect of modification of siRNA molecules delivered with aminopropylsilanol nanoparticles on suppression of A/H5N1 virus in cell culture
Repkova, Marina, Mazurkov, Oleg, Filippova, Ekaterina, Protsenko, Maria, Mazurkova, Natalia, Meschaninova, Maria, Levina, Asya, Zarytova, Valentina
Published in Biochimica et biophysica acta. General subjects (01.12.2024)
Published in Biochimica et biophysica acta. General subjects (01.12.2024)
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The Role of Dendritic Brain-Derived Neurotrophic Factor Transcripts on Altered Inhibitory Circuitry in Depression
Oh, Hyunjung, Piantadosi, Sean C., Rocco, Brad R., Lewis, David A., Watkins, Simon C., Sibille, Etienne
Published in Biological psychiatry (1969) (15.03.2019)
Published in Biological psychiatry (1969) (15.03.2019)
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JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study
Milara, Javier, Ballester, Beatriz, Morell, Anselm, Ortiz, José L, Escrivá, Juan, Fernández, Estrella, Perez-Vizcaino, Francisco, Cogolludo, Angel, Pastor, Enrique, Artigues, Enrique, Morcillo, Esteban, Cortijo, Julio
Published in Thorax (01.06.2018)
Published in Thorax (01.06.2018)
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Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway
Gondouin, Bertrand, Cerini, Claire, Dou, Laetitia, Sallée, Marion, Duval-Sabatier, Ariane, Pletinck, Anneleen, Calaf, Raymond, Lacroix, Romaric, Jourde-Chiche, Noémie, Poitevin, Stéphane, Arnaud, Laurent, Vanholder, Raymond, Brunet, Philippe, Dignat-George, Françoise, Burtey, Stéphane
Published in Kidney international (01.10.2013)
Published in Kidney international (01.10.2013)
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Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
Faghihi, Mohammad Ali, Modarresi, Farzaneh, Khalil, Ahmad M, Wood, Douglas E, Sahagan, Barbara G, Morgan, Todd E, Finch, Caleb E, St. Laurent III, Georges, Kenny, Paul J, Wahlestedt, Claes
Published in Nature medicine (01.07.2008)
Published in Nature medicine (01.07.2008)
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Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization
van der Kwast, Reginald V.C.T., van Ingen, Eva, Parma, Laura, Peters, Hendrika A.B., Quax, Paul H.A., Nossent, A. Yaël
Published in Circulation research (02.02.2018)
Published in Circulation research (02.02.2018)
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Restoration of Impaired Endothelial Myocyte Enhancer Factor 2 Function Rescues Pulmonary Arterial Hypertension
Kim, Jongmin, Hwangbo, Cheol, Hu, Xiaoyue, Kang, Yujung, Papangeli, Irinna, Mehrotra, Devi, Park, Hyekyung, Ju, Hyekyung, McLean, Danielle L., Comhair, Suzy A., Erzurum, Serpil C., Chun, Hyung J.
Published in Circulation (New York, N.Y.) (13.01.2015)
Published in Circulation (New York, N.Y.) (13.01.2015)
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Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells
Sarkar, Susobhan, Döring, Axinia, Zemp, Franz J, Silva, Claudia, Lun, Xueqing, Wang, Xiuling, Kelly, John, Hader, Walter, Hamilton, Mark, Mercier, Philippe, Dunn, Jeff F, Kinniburgh, Dave, van Rooijen, Nico, Robbins, Stephen, Forsyth, Peter, Cairncross, Gregory, Weiss, Samuel, Yong, V Wee
Published in Nature neuroscience (01.01.2014)
Published in Nature neuroscience (01.01.2014)
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The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies
Janas, Maja M., Harbison, Carole E., Perry, Victoria K., Carito, Brenda, Sutherland, Jessica E., Vaishnaw, Akshay K., Keirstead, Natalie D., Warner, Garvin
Published in Toxicologic pathology (01.10.2018)
Published in Toxicologic pathology (01.10.2018)
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Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor
Zhu, Liping, Xiao, Rui, Zhang, Xiuyun, Lang, Yuheng, Liu, Fangbo, Yu, Zhe, Zhang, Jiwei, Su, Yuan, Lu, Yankai, Wang, Tao, Luo, Shengquan, Wang, Jian, Liu, Ming-Lin, Dupuis, Jocelyn, Jing, Zhi-Cheng, Li, Tong, Xiong, Weining, Hu, Qinghua
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2019)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2019)
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Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice
Ai, Ding, Chen, Chiyuan, Han, Seongah, Ganda, Anjali, Murphy, Andrew J., Haeusler, Rebecca, Thorp, Edward, Accili, Domenico, Horton, Jay D., Tall, Alan R.
Published in The Journal of clinical investigation (01.04.2012)
Published in The Journal of clinical investigation (01.04.2012)
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The YY1/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface
Tian, Fu-Ju, Cheng, Yan-Xiang, Li, Xiao-Cui, Wang, Fa, Qin, Chuan-Mei, Ma, Xiao-Ling, Yang, Jing, Lin, Yi
Published in The Journal of pathology (01.05.2016)
Published in The Journal of pathology (01.05.2016)
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Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells
Ghosh, Chaitali, Hossain, Mohammed, Solanki, Jesal, Najm, Imad M., Marchi, Nicola, Janigro, Damir
Published in Epilepsia (Copenhagen) (01.04.2017)
Published in Epilepsia (Copenhagen) (01.04.2017)
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Activation of Transient Receptor Potential Vanilloid Type-1 Channel Prevents Adipogenesis and Obesity
Zhang, Li Li, Liu, Dao Yan, Ma, Li Qun, Luo, Zhi Dan, Cao, Ting Bing, Zhong, Jian, Yan, Zhen Cheng, Wang, Li Juan, Zhao, Zhi Gang, Zhu, Shan Jun, Schrader, Mark, Thilo, Florian, Zhu, Zhi Ming, Tepel, Martin
Published in Circulation research (13.04.2007)
Published in Circulation research (13.04.2007)
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Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis
Pidoux, Guillaume, Witczak, Oliwia, Jarnæss, Elisabeth, Myrvold, Linda, Urlaub, Henning, Stokka, Anne Jorunn, Küntziger, Thomas, Taskén, Kjetil
Published in The EMBO journal (02.11.2011)
Published in The EMBO journal (02.11.2011)
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