Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors
Young, Mary Beth, Barrow, James C, Glass, Kristen L, Lundell, George F, Newton, Christina L, Pellicore, Janetta M, Rittle, Kenneth E, Selnick, Harold G, Stauffer, Kenneth J, Vacca, Joseph P, Williams, Peter D, Bohn, Dennis, Clayton, Franklin C, Cook, Jacquelynn J, Krueger, Julie A, Kuo, Lawrence C, Lewis, S. Dale, Lucas, Bobby J, McMasters, Daniel R, Miller-Stein, Cynthia, Pietrak, Beth L, Wallace, Audrey A, White, Rebecca B, Wong, Bradley, Yan, Youwei, Nantermet, Philippe G
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1
Barrow, James C., Rittle, Kenneth E., Ngo, Phung L., Selnick, Harold G., Graham, Samuel L., Pitzenberger, Steven M., McGaughey, Georgia B., Colussi, Dennis, Lai, Ming-Tain, Huang, Qian, Tugusheva, Katherine, Espeseth, Amy S., Simon, Adam J., Munshi, Sanjeev K., Vacca, Joseph P.
Published in ChemMedChem (09.07.2007)
Published in ChemMedChem (09.07.2007)
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Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels
Yang, Zhi-Qiang, Barrow, James C, Shipe, William D, Schlegel, Kelly-Ann S, Shu, Youheng, Yang, F. Vivien, Lindsley, Craig W, Rittle, Kenneth E, Bock, Mark G, Hartman, George D, Uebele, Victor N, Nuss, Cindy E, Fox, Steve V, Kraus, Richard L, Doran, Scott M, Connolly, Thomas M, Tang, Cuyue, Ballard, Jeanine E, Kuo, Yuhsin, Adarayan, Emily D, Prueksaritanont, Thomayant, Zrada, Matthew M, Marino, Michael J, Graufelds, Valerie Kuzmick, DiLella, Anthony G, Reynolds, Ian J, Vargas, Hugo M, Bunting, Patricia B, Woltmann, Richard F, Magee, Michael M, Koblan, Kenneth S, Renger, John J
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase
Barrow, James C, Stauffer, Shaun R, Rittle, Kenneth E, Ngo, Phung L, Yang, ZhiQiang, Selnick, Harold G, Graham, Samuel L, Munshi, Sanjeev, McGaughey, Georgia B, Holloway, M. Katharine, Simon, Adam J, Price, Eric A, Sankaranarayanan, Sethu, Colussi, Dennis, Tugusheva, Katherine, Lai, Ming-Tain, Espeseth, Amy S, Xu, Min, Huang, Qian, Wolfe, Abigail, Pietrak, Beth, Zuck, Paul, Levorse, Dorothy A, Hazuda, Daria, Vacca, Joseph P
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists
Schlegel, Kelly-Ann S., Yang, Zhi-Qiang, Reger, Thomas S., Shu, Youheng, Cube, Rowena, Rittle, Kenneth E., Bondiskey, Phung, Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Kraus, Richard L., Li, Yuxing, Uebele, Victor N., Renger, John J., Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Pyridyl amides as potent inhibitors of T-type calcium channels
Reger, Thomas S., Yang, Zhi-Qiang, Schlegel, Kelly-Ann S., Shu, Youheng, Mattern, Christa, Cube, Rowena, Rittle, Kenneth E., McGaughey, Georgia B., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Li, Yuxing, Kraus, Richard L., Uebele, Victor N., Renger, John J., Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists
Uebele, Victor N, Nuss, Cindy E, Fox, Steven V, Garson, Susan L, Cristescu, Razvan, Doran, Scott M, Kraus, Richard L, Santarelli, Vincent P, Li, Yuxing, Barrow, James C, Yang, Zhi-Qiang, Schlegel, Kelly-Ann S, Rittle, Kenneth E, Reger, Thomas S, Bednar, Rodney A, Lemaire, Wei, Mullen, Faith A, Ballard, Jeanine E, Tang, Cuyue, Dai, Ge, McManus, Owen B, Koblan, Kenneth S, Renger, John J
Published in Cell biochemistry and biophysics (01.11.2009)
Published in Cell biochemistry and biophysics (01.11.2009)
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Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation
Stauffer, Shaun R., Stanton, Matthew G., Gregro, Alison R., Steinbeiser, Melissa A., Shaffer, Jennifer R., Nantermet, Philippe G., Barrow, James C., Rittle, Kenneth E., Collusi, Dennis, Espeseth, Amy S., Lai, Ming-Tain, Pietrak, Beth L., Holloway, M. Katharine, McGaughey, Georgia B., Munshi, Sanjeev K., Hochman, Jerome H., Simon, Adam J., Selnick, Harold G., Graham, Samuel L., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Journal Article
Orally active, nonpeptide oxytocin antagonists
Evans, Ben E, Leighton, James L, Rittle, Kenneth E, Gilbert, Kevin F, Lundell, George F, Gould, Norman P, Hobbs, Doug W, DiPardo, Robert M, Veber, Daniel F, Pettibone, Douglas J, Clineschmidt, Bradley V, Anderson, Paul S, Freidinger, Roger M
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Journal Article
Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists
Barrow, James C, Rittle, Kenneth E, Reger, Thomas S, Yang, Zhi-Qiang, Bondiskey, Phung, McGaughey, Georgia B, Bock, Mark G, Hartman, George D, Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E, Doran, Scott M, Fox, Steven V, Garson, Susan L, Kraus, Richard L, Li, Yuxing, Marino, Michael J, Kuzmick Graufelds, Valerie, Uebele, Victor N, Renger, John J
Published in ACS medicinal chemistry letters (13.05.2010)
Published in ACS medicinal chemistry letters (13.05.2010)
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Journal Article
In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia
Barrow, James C, Nantermet, Philippe G, Selnick, Harold G, Glass, Kristen L, Rittle, Kenneth E, Gilbert, Kevin F, Steele, Thomas G, Homnick, Carl F, Freidinger, Roger M, Ransom, Rick W, Kling, Paul, Reiss, Duane, Broten, Theodore P, Schorn, Terry W, Chang, Raymond S. L, O'Malley, Stacey S, Olah, Timothy V, Ellis, Joan D, Barrish, Andrea, Kassahun, Kelem, Leppert, Paula, Nagarathnam, Dhanapalan, Forray, Carlos
Published in Journal of medicinal chemistry (13.07.2000)
Published in Journal of medicinal chemistry (13.07.2000)
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A stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and .gamma.-(aminoalkyl)-.gamma.-lactones
Evans, Ben E, Rittle, Kenneth E, Homnick, Carl F, Springer, James P, Hirshfield, Jordan, Veber, Daniel F
Published in Journal of organic chemistry (01.11.1985)
Published in Journal of organic chemistry (01.11.1985)
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Journal Article
Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel Antagonist
Shipe, William D, Barrow, James C, Yang, Zhi-Qiang, Lindsley, Craig W, Yang, F. Vivien, Schlegel, Kelly-Ann S, Shu, Youheng, Rittle, Kenneth E, Bock, Mark G, Hartman, George D, Tang, Cuyue, Ballard, Jeanine E, Kuo, Yuhsin, Adarayan, Emily D, Prueksaritanont, Thomayant, Zrada, Matthew M, Uebele, Victor N, Nuss, Cindy E, Connolly, Thomas M, Doran, Scott M, Fox, Steven V, Kraus, Richard L, Marino, Michael J, Graufelds, Valerie Kuzmick, Vargas, Hugo M, Bunting, Patricia B, Hasbun-Manning, Martha, Evans, Rose M, Koblan, Kenneth S, Renger, John J
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Journal Article
Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position
RITTLE, Kenneth E, BARROW, James C, NANTERMET, Philippe G, NEWTON, Christina L, SANDERS, William M, YOUWEI YAN, VACCA, Joseph P, SELNICK, Harold G, CUTRONA, Kellie J, GLASS, Kristen L, KRUEGER, Julie A, KUO, Lawrence C, LEWIS, S. Dale, LUCAS, Bobby J, MCMASTERS, Daniel R, MORRISSETTE, Matthew M
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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Journal Article
Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)
Nantermet, Philippe G, Barrow, James C, Lundell, George F, Pellicore, Janetta M, Rittle, Kenneth E, Young, MaryBeth, Freidinger, Roger M, Connolly, Thomas M, Condra, Cindra, Karczewski, Jerzy, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Prendergast, Kris, Selnick, Harold G
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
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Journal Article
Benzodiazepine gastrin and brain cholecystokinin receptor ligands; L-365,260
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Veber, Daniel F, Anderson, Paul S, Freidinger, Roger M
Published in Journal of medicinal chemistry (01.01.1989)
Published in Journal of medicinal chemistry (01.01.1989)
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Journal Article
Development of 1,4-benzodiazepine cholecystokinin type B antagonists
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Garsky, Victor M, Gilbert, Kevin F, Leighton, James L, Carson, Kenneth L
Published in Journal of medicinal chemistry (24.12.1993)
Published in Journal of medicinal chemistry (24.12.1993)
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Journal Article
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca(2+) channel antagonist
Shipe, William D., Barrow, James C., Yang, Zhi-Qiang, Lindsley, Craig W., Yang, F. Vivien, Schlegel, Kelly-Ann S., Shu, Youheng, Rittle, Kenneth E., Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine E., Kuo, Yuhsin, Adarayan, Emily D., Prueksaritanont, Thomayant, Zrada, Matthew M., Uebele, Victor N., Nuss, Cindy E., Connolly, Thomas M., Doran, Scott M., Fox, Steven V., Kraus, Richard L., Marino, Michael J., Gratifelds, Valerie Kuzmick, Vargas, Hugo M., Bunting, Patricia B., Hasbun-Manning, Martha, Evans, Rose M., Koblan, Kenneth S., Renger, John J.
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Synthesis, assignment of absolute configuration, and receptor binding studies relevant to the neuroleptic activities of a series of chiral 3-substituted cyproheptadine atropisomers
Randall, William C, Anderson, Paul S, Cresson, Emlen L, Hunt, Cecilia A, Lyon, Thomas F, Rittle, Kenneth E, Remy, David C, Springer, James P, Hirshfield, Jordan M
Published in Journal of medicinal chemistry (01.10.1979)
Published in Journal of medicinal chemistry (01.10.1979)
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Journal Article
Transannular reactions of dibenzo[a,d]cycloalkenes. 2. Synthesis of bridgehead substituted dibenzo[a,d]cycloalkenimines by a regiospecific transannular amine to olefin addition
Evans, Ben E, Anderson, Paul S, Christy, Marcia E, Colton, C. Dylion, Remy, David C, Rittle, Kenneth E, Engelhardt, Edward L
Published in Journal of organic chemistry (01.08.1979)
Published in Journal of organic chemistry (01.08.1979)
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