In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia
Barrow, JC, Nantermet, PG, Selnick, HG, Glass, KL, Rittle, KE, Gilbert, KF, Steele, TG, Homnick, CF, Freidinger, RM, Ransom, RW, Kling, P, Reiss, D, Broten, TP, Schorn, TW, Chang, RSL, O'Malley, SS, Olah, TV, Ellis, JD, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C
Published in Journal of medicinal chemistry (13.07.2000)
Published in Journal of medicinal chemistry (13.07.2000)
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Journal Article
Discovery and evaluation of potent P-1 aryl heterocycle-based thrombin inhibitors
Young, MB, Barrow, JC, Glass, KL, Lundell, GF, Newton, CL, Pellicore, JM, Rittle, KE, Selnick, HG, Stauffer, KJ, Vacca, JP, Williams, PD, Bohn, D, Clayton, FC, Cook, JJ, Krueger, JA, Kuo, LC, Lewis, SD, Lucas, BJ, McMasters, DR, Miller-Stein, C, Pietrak, BL, Wallace, AA, White, RB, Wong, B, Yan, YW, Nantermet, PG
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists
Barrow, James C, Rittle, Kenneth E, Reger, Thomas S, Yang, Zhi-Qiang, Bondiskey, Phung, McGaughey, Georgia B, Bock, Mark G, Hartman, George D, Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E, Doran, Scott M, Fox, Steven V, Garson, Susan L, Kraus, Richard L, Li, Yuxing, Marino, Michael J, Kuzmick Graufelds, Valerie, Uebele, Victor N, Renger, John J
Published in ACS medicinal chemistry letters (13.05.2010)
Published in ACS medicinal chemistry letters (13.05.2010)
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Journal Article
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
Evans, B. E, Rittle, K. E, Bock, M. G, DiPardo, R. M, Freidinger, R. M, Whitter, W. L, Lundell, G. F, Veber, D. F, Anderson, P. S, Chang, R. S. L, Lotti, V. J, Cerino, D. J, Chen, T. B, Kling, P. J, Kunkel, K. A, Springer, J. P, Hirshfield, J
Published in Journal of medicinal chemistry (01.12.1988)
Published in Journal of medicinal chemistry (01.12.1988)
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Journal Article
Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position
RITTLE, Kenneth E, BARROW, James C, NANTERMET, Philippe G, NEWTON, Christina L, SANDERS, William M, YOUWEI YAN, VACCA, Joseph P, SELNICK, Harold G, CUTRONA, Kellie J, GLASS, Kristen L, KRUEGER, Julie A, KUO, Lawrence C, LEWIS, S. Dale, LUCAS, Bobby J, MCMASTERS, Daniel R, MORRISSETTE, Matthew M
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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Journal Article
Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)
Nantermet, Philippe G, Barrow, James C, Lundell, George F, Pellicore, Janetta M, Rittle, Kenneth E, Young, MaryBeth, Freidinger, Roger M, Connolly, Thomas M, Condra, Cindra, Karczewski, Jerzy, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Prendergast, Kris, Selnick, Harold G
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
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Journal Article
Benzodiazepine gastrin and brain cholecystokinin receptor ligands; L-365,260
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Veber, Daniel F, Anderson, Paul S, Freidinger, Roger M
Published in Journal of medicinal chemistry (01.01.1989)
Published in Journal of medicinal chemistry (01.01.1989)
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Journal Article
Design of Potent, Orally Effective, Nonpeptidal Antagonists of the Peptide Hormone Cholecystokinin
Evans, Ben E., Bock, Mark G., Rittle, Kenneth E., DiPardo, Robert M., Whitter, Willie L., Veber, Daniel F., Anderson, Paul S., Freidinger, Roger M.
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1986)
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1986)
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Journal Article
Development of 1,4-benzodiazepine cholecystokinin type B antagonists
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Garsky, Victor M, Gilbert, Kevin F, Leighton, James L, Carson, Kenneth L
Published in Journal of medicinal chemistry (24.12.1993)
Published in Journal of medicinal chemistry (24.12.1993)
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A stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and .gamma.-(aminoalkyl)-.gamma.-lactones
Evans, Ben E, Rittle, Kenneth E, Homnick, Carl F, Springer, James P, Hirshfield, Jordan, Veber, Daniel F
Published in Journal of organic chemistry (01.11.1985)
Published in Journal of organic chemistry (01.11.1985)
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Journal Article
NANOMOLAR-AFFINITY, NONPEPTIDE OXYTOCIN RECEPTOR ANTAGONISTS
EVANS, BE, LUNDELL, GF, GILBERT, KF, BOCK, MG, RITTLE, KE, CARROLL, LA, WILLIAMS, PD, PAWLUCZYK, JM, LEIGHTON, JL, YOUNG, MB, ERB, JM, HOBBS, DW, GOULD, NP, DIPARDO, RM, HOFFMAN, JB, PERLOW, DS, WHITTER, WL, VEBER, DF, PETTIBONE, DJ, CLINESCHMIDT, BV, ANDERSON, PS, FREIDINGER, RM
Published in Journal of medicinal chemistry (10.12.1993)
Published in Journal of medicinal chemistry (10.12.1993)
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Journal Article
Synthesis and resolution of 3-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Veber, Daniel F, Freidinger, Roger M, Hirshfield, Jordan, Springer, James P
Published in Journal of organic chemistry (01.07.1987)
Published in Journal of organic chemistry (01.07.1987)
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Journal Article
A synthesis of statine utilizing an oxidative route to chiral .alpha.-amino aldehydes
Rittle, Kenneth E., Homnick, Carl F., Ponticello, Gerald S., Evans, Ben E.
Published in Journal of organic chemistry (01.07.1982)
Published in Journal of organic chemistry (01.07.1982)
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Journal Article
Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists
Evans, B. E, Rittle, K. E, Bock, M. G, DiPardo, R. M, Freidinger, R. M, Whitter, W. L, Gould, N. P, Lundell, G. F, Homnick, C. F
Published in Journal of medicinal chemistry (01.07.1987)
Published in Journal of medicinal chemistry (01.07.1987)
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Journal Article
Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Freidinger, Roger M, Rittle, Kenneth E, Payne, Linda S, Boger, Joshua, Whitter, Willie L, LaMont, Bruce I
Published in Journal of medicinal chemistry (01.10.1988)
Published in Journal of medicinal chemistry (01.10.1988)
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Journal Article
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives
Hoffman, William F, Alberts, A. W, Cragoe, E. J, Deana, A. A, Evans, B. E, Gilfillan, J. L, Gould, N. P, Huff, J. W, Novello, F. C
Published in Journal of medicinal chemistry (01.02.1986)
Published in Journal of medicinal chemistry (01.02.1986)
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Journal Article
Cholecystokinin-A receptor ligands based on the .kappa.-opioid agonist tifluadom
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Veber, Daniel F, Freidinger, Roger M, Chang, Raymond S. L, Chen, T. B, Lotti, Victor J
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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Journal Article
A NEW AMINE RESOLUTION METHOD AND ITS APPLICATION TO 3-AMINOBENZODIAZEPINES
RITTLE, KE, EVANS, BE, BOCK, MG, DIPARDO, RM, WHITTER, WL, HOMNICK, CF, VEBER, DF, FREIDINGER, RM
Published in Tetrahedron letters (01.01.1987)
Published in Tetrahedron letters (01.01.1987)
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Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted 1,4-benzodiazepin-2-amines
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Freidinger, Roger M, Chang, Raymond S. L, Lotti, Victor J
Published in Journal of medicinal chemistry (01.01.1988)
Published in Journal of medicinal chemistry (01.01.1988)
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