Search Results - "RITA SCARPELLI" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

by Summa, Vincenzo, Petrocchi, Alessia, Bonelli, Fabio, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Fiore, Fabrizio, Gardelli, Cristina, Gonzalez Paz, Odalys, Hazuda, Daria J, Jones, Philip, Kinzel, Olaf, Laufer, Ralph, Monteagudo, Edith, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Scarpelli, Rita, Stillmock, Kara, Witmer, Marc V, Rowley, Michael
Published in Journal of medicinal chemistry (25.09.2008)

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Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors

Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors

by Jones, Philip, Altamura, Sergio, Boueres, Julia, Ferrigno, Federica, Fonsi, Massimiliano, Giomini, Claudia, Lamartina, Stefania, Monteagudo, Edith, Ontoria, Jesus M, Orsale, Maria Vittoria, Palumbi, Maria Cecilia, Pesci, Silvia, Roscilli, Giuseppe, Scarpelli, Rita, Schultz-Fademrecht, Carsten, Toniatti, Carlo, Rowley, Michael
Published in Journal of medicinal chemistry (26.11.2009)

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Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

by Bottomley, Matthew J., Lo Surdo, Paola, Di Giovine, Paolo, Cirillo, Agostino, Scarpelli, Rita, Ferrigno, Federica, Jones, Philip, Neddermann, Petra, De Francesco, Raffaele, Steinkühler, Christian, Gallinari, Paola, Carfí, Andrea
Published in The Journal of biological chemistry (26.09.2008)

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Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

by Greco, Rosaria, Demartini, Chiara, Zanaboni, Anna Maria, Francavilla, Miriam, Reggiani, Angelo, Realini, Natalia, Scarpelli, Rita, Piomelli, Daniele, Tassorelli, Cristina
Published in Journal of headache and pain (01.12.2022)

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Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions

by Sasso, Oscar, Bertorelli, Rosalia, Bandiera, Tiziano, Scarpelli, Rita, Colombano, Giampiero, Armirotti, Andrea, Moreno-Sanz, Guillermo, Reggiani, Angelo, Piomelli, Daniele
Published in Pharmacological research (01.05.2012)

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Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor

Identification and Characterization of Carprofen as a Multitarget Fatty Acid Amide Hydrolase/Cyclooxygenase Inhibitor

by Favia, Angelo D, Habrant, Damien, Scarpelli, Rita, Migliore, Marco, Albani, Clara, Bertozzi, Sine Mandrup, Dionisi, Mauro, Tarozzo, Glauco, Piomelli, Daniele, Cavalli, Andrea, De Vivo, Marco
Published in Journal of medicinal chemistry (25.10.2012)

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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1

by Malancona, Savina, Altamura, Sergio, Filocamo, Gessica, Kinzel, Olaf, Hernando, Jose Ignacio Martin, Rowley, Michael, Scarpelli, Rita, Steinkühler, Christian, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (01.08.2011)

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Journal Article

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2

by Kinzel, Olaf, Alfieri, Anna, Altamura, Sergio, Brunetti, Mirko, Bufali, Simone, Colaceci, Fabrizio, Ferrigno, Federica, Filocamo, Gessica, Fonsi, Massimiliano, Gallinari, Paola, Malancona, Savina, Hernando, Jose Ignacio Martin, Monteagudo, Edith, Orsale, Maria Vittoria, Palumbi, Maria Cecilia, Pucci, Vincenzo, Rowley, Michael, Sasso, Romina, Scarpelli, Rita, Steinkühler, Christian, Jones, Philip
Published in Bioorganic & medicinal chemistry letters (01.08.2011)

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Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy

Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy

by Palomba, Martina, Vecchio, Donatella, Allavena, Giulia, Capaccio, Vito, De Mei, Claudia, Scarpelli, Rita, Grimaldi, Benedetto
Published in Journal of medicinal chemistry (11.01.2024)

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A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation

A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation

by Scarpelli, Rita, Sasso, Oscar, Piomelli, Daniele
Published in ChemMedChem (20.06.2016)

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Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy

Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy

by Torrente, Esther, Parodi, Chiara, Ercolani, Luisa, De Mei, Claudia, Ferrari, Alessio, Scarpelli, Rita, Grimaldi, Benedetto
Published in Journal of medicinal chemistry (13.08.2015)

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Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage

Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage

by Sasso, Oscar, Migliore, Marco, Habrant, Damien, Armirotti, Andrea, Albani, Clara, Summa, Maria, Moreno-Sanz, Guillermo, Scarpelli, Rita, Piomelli, Daniele
Published in The FASEB journal (01.06.2015)

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Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification

Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification

by Falchi, Federico, Bertozzi, Sine Mandrup, Ottonello, Giuliana, Ruda, Gian Filippo, Colombano, Giampiero, Fiorelli, Claudio, Martucci, Cataldo, Bertorelli, Rosalia, Scarpelli, Rita, Cavalli, Andrea, Bandiera, Tiziano, Armirotti, Andrea
Published in Analytical chemistry (Washington) (04.10.2016)

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Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

by Prati, Federica, De Simone, Angela, Bisignano, Paola, Armirotti, Andrea, Summa, Maria, Pizzirani, Daniela, Scarpelli, Rita, Perez, Daniel I., Andrisano, Vincenza, Perez-Castillo, Ana, Monti, Barbara, Massenzio, Francesca, Polito, Letizia, Racchi, Marco, Favia, Angelo D., Bottegoni, Giovanni, Martinez, Ana, Bolognesi, Maria Laura, Cavalli, Andrea
Published in Angewandte Chemie International Edition (26.01.2015)

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Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure–Activity Relationship (SAR) Studies

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure–Activity Relationship (SAR) Studies

by Bach, Anders, Pizzirani, Daniela, Realini, Natalia, Vozella, Valentina, Russo, Debora, Penna, Ilaria, Melzig, Laurin, Scarpelli, Rita, Piomelli, Daniele
Published in Journal of medicinal chemistry (10.12.2015)

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Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies

Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies

by Migliore, Marco, Habrant, Damien, Sasso, Oscar, Albani, Clara, Bertozzi, Sine Mandrup, Armirotti, Andrea, Piomelli, Daniele, Scarpelli, Rita
Published in European journal of medicinal chemistry (15.02.2016)

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Fluorine nuclear magnetic resonance-based assay in living mammalian cells

Fluorine nuclear magnetic resonance-based assay in living mammalian cells

by Veronesi, Marina, Giacomina, Francesca, Romeo, Elisa, Castellani, Beatrice, Ottonello, Giuliana, Lambruschini, Chiara, Garau, Gianpiero, Scarpelli, Rita, Bandiera, Tiziano, Piomelli, Daniele, Dalvit, Claudio
Published in Analytical biochemistry (15.02.2016)

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Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure–Activity Relationship (SAR)

Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure–Activity Relationship (SAR)

by Pizzirani, Daniela, Pagliuca, Chiara, Realini, Natalia, Branduardi, Davide, Bottegoni, Giovanni, Mor, Marco, Bertozzi, Fabio, Scarpelli, Rita, Piomelli, Daniele, Bandiera, Tiziano
Published in Journal of medicinal chemistry (09.05.2013)

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Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors

Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors

by Caputo, Samantha, Di Martino, Simona, Cilibrasi, Vincenzo, Tardia, Piero, Mazzonna, Marco, Russo, Debora, Penna, Ilaria, Summa, Maria, Bertozzi, Sine Mandrup, Realini, Natalia, Margaroli, Natasha, Migliore, Marco, Ottonello, Giuliana, Liu, Min, Lansbury, Peter, Armirotti, Andrea, Bertorelli, Rosalia, Ray, Soumya S, Skerlj, Renato, Scarpelli, Rita
Published in Journal of medicinal chemistry (24.12.2020)

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A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase

A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase

by Bertolacci, Laura, Romeo, Elisa, Veronesi, Marina, Magotti, Paola, Albani, Clara, Dionisi, Mauro, Lambruschini, Chiara, Scarpelli, Rita, Cavalli, Andrea, De Vivo, Marco, Piomelli, Daniele, Garau, Gianpiero
Published in Journal of the American Chemical Society (09.01.2013)

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