Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Huo, Jiandong, Le Bas, Audrey, Ruza, Reinis R, Duyvesteyn, Helen M E, Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N, Ren, Jingshan, Zhou, Daming, Harrison, Peter J, Weckener, Miriam, Clare, Daniel K, Vogirala, Vinod K, Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L, Tree, Julia A, Buttigieg, Karen R, Coombes, Naomi, Elmore, Michael J, Carroll, Miles W, Carrique, Loic, Shah, Pranav N M, James, William, Townsend, Alain R, Stuart, David I, Owens, Raymond J, Naismith, James H
Published in Nature structural & molecular biology (01.09.2020)
Published in Nature structural & molecular biology (01.09.2020)
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike
Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.
Published in Cell Host & Microbe (09.09.2020)
Published in Cell Host & Microbe (09.09.2020)
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Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation
Rahikainen, Rolle, Rijal, Pramila, Tan, Tiong Kit, Wu, Hung‐Jen, Andersson, Anne‐Marie C., Barrett, Jordan R., Bowden, Thomas A., Draper, Simon J., Townsend, Alain R., Howarth, Mark
Published in Angewandte Chemie International Edition (04.01.2021)
Published in Angewandte Chemie International Edition (04.01.2021)
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Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors
Kandasamy, Matheswaran, Gileadi, Uzi, Rijal, Pramila, Tan, Tiong Kit, Lee, Lian N, Chen, Jili, Prota, Gennaro, Klenerman, Paul, Townsend, Alain, Cerundolo, Vincenzo
Published in eLife (10.01.2023)
Published in eLife (10.01.2023)
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Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
Huang, Kuan-Ying A, Tan, Tiong Kit, Chen, Ting-Hua, Huang, Chung-Guei, Harvey, Ruth, Hussain, Saira, Chen, Cheng-Pin, Harding, Adam, Gilbert-Jaramillo, Javier, Liu, Xu, Knight, Michael, Schimanski, Lisa, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Jan, Jia-Tsrong, Ma, Che, James, William, Daniels, Rodney S, McCauley, John W, Rijal, Pramila, Townsend, Alain R
Published in PLoS pathogens (01.02.2021)
Published in PLoS pathogens (01.02.2021)
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Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2
Huang, Kuan-Ying A, Chen, Xiaorui, Mohapatra, Arpita, Nguyen, Hong Thuy Vy, Schimanski, Lisa, Tan, Tiong Kit, Rijal, Pramila, Vester, Susan K, Hills, Rory A, Howarth, Mark, Keeffe, Jennifer R, Cohen, Alexander A, Kakutani, Leesa M, Wu, Yi-Min, Shahed-Al-Mahmud, Md, Chou, Yu-Chi, Bjorkman, Pamela J, Townsend, Alain R, Ma, Che
Published in Nature communications (19.01.2023)
Published in Nature communications (19.01.2023)
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The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine
Chen, Xiaorui, Mohapatra, Arpita, Nguyen, Hong Thuy Vy, Schimanski, Lisa, Kit Tan, Tiong, Rijal, Pramila, Chen, Cheng-Pin, Cheng, Shu-Hsing, Lee, Wen-Hsin, Chou, Yu-Chi, Townsend, Alain R, Ma, Che, Huang, Kuan-Ying A
Published in PLoS pathogens (10.06.2024)
Published in PLoS pathogens (10.06.2024)
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Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells
Martini, Veronica, Edmans, Matthew, Gubbins, Simon, Jayaraman, Siddharth, Paudyal, Basudev, Morgan, Sophie, McNee, Adam, Morin, Théo, Rijal, Pramila, Gerner, Wilhelm, Sewell, Andrew K, Inoue, Ryo, Bailey, Mick, Connelley, Timothy, Charleston, Bryan, Townsend, Alain, Beverley, Peter, Tchilian, Elma
Published in Mucosal immunology (01.03.2022)
Published in Mucosal immunology (01.03.2022)
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Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans
Rijal, Pramila, Elias, Sean C., Machado, Samara Rosendo, Xiao, Julie, Schimanski, Lisa, O’Dowd, Victoria, Baker, Terry, Barry, Emily, Mendelsohn, Simon C., Cherry, Catherine J., Jin, Jing, Labbé, Geneviève M., Donnellan, Francesca R., Rampling, Tommy, Dowall, Stuart, Rayner, Emma, Findlay-Wilson, Stephen, Carroll, Miles, Guo, Jia, Xu, Xiao-Ning, Huang, Kuan-Ying A., Takada, Ayato, Burgess, Gillian, McMillan, David, Popplewell, Andy, Lightwood, Daniel J., Draper, Simon J., Townsend, Alain R.
Published in Cell reports (Cambridge) (02.04.2019)
Published in Cell reports (Cambridge) (02.04.2019)
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Fc-Mediated Functions of Porcine IgG Subclasses
Paudyal, Basudev, Mwangi, William, Rijal, Pramila, Schwartz, John C, Noble, Alistair, Shaw, Andrew, Sealy, Joshua E, Bonnet-Di Placido, Marie, Graham, Simon P, Townsend, Alain, Hammond, John A, Tchilian, Elma
Published in Frontiers in immunology (09.06.2022)
Published in Frontiers in immunology (09.06.2022)
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A direct contact pig influenza challenge model for assessing protective efficacy of monoclonal antibodies
McNee, Adam, Vanover, Daryll, Rijal, Pramila, Paudyal, Basudev, Lean, Fabian Z X, MacLoughlin, Ronan, Núñez, Alejandro, Townsend, Alain, Santangelo, Philip J, Tchilian, Elma
Published in Frontiers in immunology (27.10.2023)
Published in Frontiers in immunology (27.10.2023)
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Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8 + T cells
Barnkob, Mike B, Michaels, Yale S, André, Violaine, Macklin, Philip S, Gileadi, Uzi, Valvo, Salvatore, Rei, Margarida, Kulicke, Corinna, Chen, Ji-Li, Jain, Vitul, Woodcock, Victoria K, Colin-York, Huw, Hadjinicolaou, Andreas V, Kong, Youxin, Mayya, Viveka, Mazet, Julie M, Mead, Gracie-Jennah, Bull, Joshua A, Rijal, Pramila, Pugh, Christopher W, Townsend, Alain R, Gérard, Audrey, Olsen, Lars R, Fritzsche, Marco, Fulga, Tudor A, Dustin, Michael L, Jones, E Yvonne, Cerundolo, Vincenzo
Published in Nature communications (24.04.2024)
Published in Nature communications (24.04.2024)
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Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells
Barnkob, Mike B., Michaels, Yale S., André, Violaine, Macklin, Philip S., Gileadi, Uzi, Valvo, Salvatore, Rei, Margarida, Kulicke, Corinna, Chen, Ji-Li, Jain, Vitul, Woodcock, Victoria K., Colin-York, Huw, Hadjinicolaou, Andreas V., Kong, Youxin, Mayya, Viveka, Mazet, Julie M., Mead, Gracie-Jennah, Bull, Joshua A., Rijal, Pramila, Pugh, Christopher W., Townsend, Alain R., Gérard, Audrey, Olsen, Lars R., Fritzsche, Marco, Fulga, Tudor A., Dustin, Michael L., Jones, E. Yvonne, Cerundolo, Vincenzo
Published in Nature communications (12.04.2024)
Published in Nature communications (12.04.2024)
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Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans
Holzer, Barbara, Rijal, Pramila, McNee, Adam, Paudyal, Basudev, Martini, Veronica, Clark, Becky, Manjegowda, Tanuja, Salguero, Francisco J, Bessell, Emily, Schwartz, John C, Moffat, Katy, Pedrera, Miriam, Graham, Simon P, Noble, Alistair, Bonnet-Di Placido, Marie, La Ragione, Roberto M, Mwangi, William, Beverley, Peter, McCauley, John W, Daniels, Rodney S, Hammond, John A, Townsend, Alain R, Tchilian, Elma
Published in PLoS pathogens (01.03.2021)
Published in PLoS pathogens (01.03.2021)
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Computational mining of B cell receptor repertoires reveals antigen-specific and convergent responses to Ebola vaccination
Richardson, Eve, Bibi, Sagida, McLean, Florence, Schimanski, Lisa, Rijal, Pramila, Ghraichy, Marie, von Niederhäusern, Valentin, Trück, Johannes, Clutterbuck, Elizabeth A, O'Connor, Daniel, Luhn, Kerstin, Townsend, Alain, Peters, Bjoern, Pollard, Andrew J, Deane, Charlotte M, Kelly, Dominic F
Published in Frontiers in immunology (08.07.2024)
Published in Frontiers in immunology (08.07.2024)
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike
Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.
Published in Cell host & microbe (09.09.2020)
Published in Cell host & microbe (09.09.2020)
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Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus
Jiang, Haihai, Peng, Weiyu, Qi, Jianxun, Chai, Yan, Song, Hao, Bi, Yuhai, Rijal, Pramila, Wang, Haiyuan, Oladejo, Babayemi O., Liu, Jinhua, Shi, Yi, Gao, George F., Townsend, Alain R., Wu, Yan
Published in mBio (27.10.2020)
Published in mBio (27.10.2020)
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Immune responses following the first dose of the Sputnik V (Gam-COVID-Vac)
Jeewandara, Chandima, Fernando, Suranga, Pushpakumara, Pradeep Darshana, Ramu, Shyrar Tanussiya, Kamaladasa, Achala, Gunasekara, Banuri, Aberathna, Inoka Sepali, Kuruppu, Heshan, Ranasinghe, Thushali, Dayarathne, Shashika, Dissanayake, Osanda, Gamalath, Nayanathara, Ekanayake, Dinithi, Jayamali, Jewantha, Wijesinghe, Ayesha, Dissanayake, Madushika, Somathilake, Gayasha, Harvie, Michael, Danasekara, Saubhagya, Jayathilaka, Deshni, Wijayatilake, Helanka Dinesh Kumara, Weerasooriya, Nihal, Kekulandara, Chinthaka, Schimanski, Lisa, Rijal, Pramila, Tan, Tiong K, Dong, Tao, Townsend, Alain, Ogg, Graham S, Malavige, Gathsaurie Neelika
Published in Scientific reports (02.02.2022)
Published in Scientific reports (02.02.2022)
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Low Dose Pig Anti-Influenza Virus Monoclonal Antibodies Reduce Lung Pathology but Do Not Prevent Virus Shedding
Paudyal, Basudev, McNee, Adam, Rijal, Pramila, Carr, B Veronica, Nunez, Alejandro, McCauley, John, Daniels, Rodney S, Townsend, Alain R, Hammond, John A, Tchilian, Elma
Published in Frontiers in immunology (16.12.2021)
Published in Frontiers in immunology (16.12.2021)
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Correction: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
Huang, Kuan-Ying A, Tan, Tiong Kit, Chen, Ting-Hua, Huang, Chung-Guei, Harvey, Ruth, Hussain, Saira, Chen, Cheng-Pin, Harding, Adam, Gilbert-Jaramillo, Javier, Liu, Xu, Knight, Michael, Schimanski, Lisa, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Jan, Jia-Tsrong, Ma, Che, James, William, Daniels, Rodney S, McCauley, John W, Rijal, Pramila, Townsend, Alain R
Published in PLoS pathogens (10.12.2021)
Published in PLoS pathogens (10.12.2021)
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