CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair
Shenoy, T.R., Boysen, G., Wang, M.Y., Xu, Q.Z., Guo, W., Koh, F.M., Wang, C., Zhang, L.Z., Wang, Y., Gil, V., Aziz, S., Christova, R., Rodrigues, D.N., Crespo, M., Rescigno, P., Tunariu, N., Riisnaes, R., Zafeiriou, Z., Flohr, P., Yuan, W., Knight, E., Swain, A., Ramalho-Santos, M., Xu, D.Y., de Bono, J., Wu, H.
Published in Annals of oncology (01.07.2017)
Published in Annals of oncology (01.07.2017)
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A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer
Kolinsky, M.P., Rescigno, P., Bianchini, D., Zafeiriou, Z., Mehra, N., Mateo, J., Michalarea, V., Riisnaes, R., Crespo, M., Figueiredo, I., Miranda, S., Nava Rodrigues, D., Flohr, P., Tunariu, N., Banerji, U., Ruddle, R., Sharp, A., Welti, J., Lambros, M., Carreira, S., Raynaud, F.I., Swales, K.E., Plymate, S., Luo, J., Tovey, H., Porta, N., Slade, R., Leonard, L., Hall, E., de Bono, J.S.
Published in Annals of oncology (01.05.2020)
Published in Annals of oncology (01.05.2020)
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Visceral Disease in Castration-resistant Prostate Cancer
Pezaro, Carmel J, Omlin, Aurelius, Lorente, David, Nava Rodrigues, Daniel, Ferraldeschi, Roberta, Bianchini, Diletta, Mukherji, Deborah, Riisnaes, Ruth, Altavilla, Amelia, Crespo, Mateus, Tunariu, Nina, de Bono, Johann S, Attard, Gerhardt
Published in European urology (01.02.2014)
Published in European urology (01.02.2014)
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Androgen receptor expression in circulating tumour cells from castration-resistant prostate cancer patients treated with novel endocrine agents
Crespo, M, van Dalum, G, Ferraldeschi, R, Zafeiriou, Z, Sideris, S, Lorente, D, Bianchini, D, Rodrigues, D N, Riisnaes, R, Miranda, S, Figueiredo, I, Flohr, P, Nowakowska, K, de Bono, J S, Terstappen, L W M M, Attard, G
Published in British journal of cancer (31.03.2015)
Published in British journal of cancer (31.03.2015)
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Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer
Sandhu, S.K., Omlin, A., Hylands, L., Miranda, S., Barber, L.J., Riisnaes, R., Reid, A.H., Attard, G., Chen, L., Kozarewa, I., Gevensleben, H., Campbell, J., Fenwick, K., Assiotis, I., Olmos, D., Yap, T.A., Fong, P., Tunariu, N., Koh, D., Molife, L.R., Kaye, S., Lord, C.J., Ashworth, A., de Bono, J.
Published in Annals of oncology (01.05.2013)
Published in Annals of oncology (01.05.2013)
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First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate cancer
BIANCHINI, D, OMLIN, A, ZIVI, A, BUCHBINDER, A, RATHKOPF, D. E, ATTARD, G, SCHER, H. I, DE BONO, J, DANILA, D. C, PEZARO, C, LORENTE, D, FERRALDESCHI, R, MUKHERJI, D, CRESPO, M, FIGUEIREDO, I, MIRANDA, S, RIISNAES, R
Published in British journal of cancer (12.11.2013)
Published in British journal of cancer (12.11.2013)
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AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer – results of two parallel first-in-human phase I studies
Omlin, A., Jones, R. J., van der Noll, R., Satoh, T., Niwakawa, M., Smith, S. A., Graham, J., Ong, M., Finkelman, R. D., Schellens, J. H. M., Zivi, A., Crespo, M., Riisnaes, R., Nava-Rodrigues, D., Malone, M. D., Dive, C., Sloane, R., Moore, D., Alumkal, J. J., Dymond, A., Dickinson, P. A., Ranson, M., Clack, G., de Bono, J., Elliott, T.
Published in Investigational new drugs (01.06.2015)
Published in Investigational new drugs (01.06.2015)
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PI3K/AKT pathway deleterious mutations in lethal prostate cancer
Rescigno, P., Rediti, M., Dolling, D., Rodrigues, D.N., Bianchini, D., Riisnaes, R., Messina, C., Barrero, M., Petremolo, A., Sharp, A., Sumanasuriya, S., Seed, G., Figueiredo, I., Miranda, S., Goodall, J., Mateo, J., Chandler, R., Yuan, W., Carreira, S., de Bono, J.S.
Published in Annals of oncology (01.10.2018)
Published in Annals of oncology (01.10.2018)
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Phase 1-2 study of progesterone receptor (PR) inhibition with extended-release (ER) onapristone (ONA) alone or in combination with abiraterone (AA) in patients (pts) with castration-resistant prostate cancer (CRPC) incorporating plasma DNA analysis to define androgen receptor (AR) status
Jayaram, A., Nowakowska, K., Mateo, J., Hernandez, T., Kumar, S., Fulton, B., Nava Rodrigues, D., Riisnaes, R., Zukiwski, A., Proniuk, S., Bexon, A.S., Bisaha, J., Bianchini, D., Zafeiriou, Z., Lopez, R.P., Tunariu, N., Pacey, S., Jones, R., de Bono, J. Sebastian, Attard, G.
Published in Annals of oncology (01.10.2017)
Published in Annals of oncology (01.10.2017)
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2558 Impact of PTEN protein loss on response to docetaxel and overall survival (OS) in metastatic castration resistant prostate cancer (mCRPC) patients
Rescigno, P, Lorente, D, Bianchini, D, Kolinsky, M, Zafeiriou, Z, Ferraldeschi, R, Mateo, J, Recine, F, Jayaram, A, Nava Rodrigues, D, Riisnaes, R, Miranda, S, Figueiredo, I, Crespo, M, Mehra, N, Perez-Lopez, R, Tunariu, N, Reid, A, Attard, G, De Bono, J
Published in European journal of cancer (1990) (01.09.2015)
Published in European journal of cancer (1990) (01.09.2015)
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DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
Mateo, Joaquin, Carreira, Suzanne, Sandhu, Shahneen, Miranda, Susana, Mossop, Helen, Perez-Lopez, Raquel, Nava Rodrigues, Daniel, Robinson, Dan, Omlin, Aurelius, Tunariu, Nina, Boysen, Gunther, Porta, Nuria, Flohr, Penny, Gillman, Alexa, Figueiredo, Ines, Paulding, Claire, Seed, George, Jain, Suneil, Ralph, Christy, Protheroe, Andrew, Hussain, Syed, Jones, Robert, Elliott, Tony, McGovern, Ursula, Bianchini, Diletta, Goodall, Jane, Zafeiriou, Zafeiris, Williamson, Chris T, Ferraldeschi, Roberta, Riisnaes, Ruth, Ebbs, Bernardette, Fowler, Gemma, Roda, Desamparados, Yuan, Wei, Wu, Yi-Mi, Cao, Xuhong, Brough, Rachel, Pemberton, Helen, A’Hern, Roger, Swain, Amanda, Kunju, Lakshmi P, Eeles, Rosalind, Attard, Gerhardt, Lord, Christopher J, Ashworth, Alan, Rubin, Mark A, Knudsen, Karen E, Feng, Felix Y, Chinnaiyan, Arul M, Hall, Emma, de Bono, Johann S
Published in The New England journal of medicine (29.10.2015)
Published in The New England journal of medicine (29.10.2015)
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121P ATM germline mutations in lethal prostate cancer
Grochot, R.M., Carreira, S., Miranda, S., Figueiredo, I., Bertan, C., Rekowski, J., Yuan, W., Ferreira, A., Riisnaes, R., Neeb, A., Gurel, B., Fenor de la Maza, M.D.L.D., Carmichael, J., Westaby, D., Guo, C., Sharp, A., de Bono, J.S.
Published in Annals of oncology (01.10.2022)
Published in Annals of oncology (01.10.2022)
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4P Targeting PI3K/AKT/mTOR pathway in platinum-resistant ovarian high-grade serous carcinoma: Translational analysis from the randomized phase II OCTOPUS trial
Giannone, G., Ennis, D., Mirza, H.B., Cheng, Z., McDermott, J., Lewsley, L-A., Clamp, A.R., Herbertson, R.A., Glasspool, R.M., Krell, J., Hinsley, S., Banerji, U., Riisnaes, R., Banerjee, S., McNeish, I.
Published in Annals of oncology (01.06.2022)
Published in Annals of oncology (01.06.2022)
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PTEN loss as a predictive biomarker for the Akt inhibitor ipatasertib combined with abiraterone acetate in patients with metastatic castration-resistant prostate cancer (mCRPC)
de Bono, J.S., De Giorgi, U., Massard, C., Bracarda, S., Nava Rodrigues, D., Kocak, I., Font, A., Arija, J. Arranz, Shih, K., Radavoi, G.D., Yu, W., Chan, W., Gendreau, S., Zhang, L., Riisnaes, R., Wongchenko, M.J., Maslyar, D., Jinga, V.
Published in Annals of oncology (01.10.2016)
Published in Annals of oncology (01.10.2016)
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838PPI3K/AKT pathway deleterious mutations in lethal prostate cancer
Rescigno, P, Rediti, M, Dolling, D, Rodrigues, D N, Bianchini, D, Riisnaes, R, Messina, C, Barrero, M, Petremolo, A, Sharp, A, Sumanasuriya, S, Seed, G, Figueiredo, I, Miranda, S, Goodall, J, Mateo, J, Chandler, R, Yuan, W, Carreira, S, de Bono, J S
Published in Annals of oncology (01.10.2018)
Published in Annals of oncology (01.10.2018)
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Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer
Cato, Laura, Neeb, Antje, Sharp, Adam, Buzón, Victor, Ficarro, Scott B, Yang, Linxiao, Muhle-Goll, Claudia, Kuznik, Nane C, Riisnaes, Ruth, Nava Rodrigues, Daniel, Armant, Olivier, Gourain, Victor, Adelmant, Guillaume, Ntim, Emmanuel A, Westerling, Thomas, Dolling, David, Rescigno, Pasquale, Figueiredo, Ines, Fauser, Friedrich, Wu, Jennifer, Rottenberg, Jaice T, Shatkina, Liubov, Ester, Claudia, Luy, Burkhard, Puchta, Holger, Troppmair, Jakob, Jung, Nicole, Bräse, Stefan, Strähle, Uwe, Marto, Jarrod A, Nienhaus, Gerd Ulrich, Al-Lazikani, Bissan, Salvatella, Xavier, de Bono, Johann S, Cato, Andrew Cb, Brown, Myles
Published in eLife (10.08.2017)
Published in eLife (10.08.2017)
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Myeloid-derived suppressor cells (MDSCs) in metastatic castration-resistant prostate cancer (CRPC) patients (PTS)
Mehra, N., Seed, G., Lambros, M., Sharp, A., Fontes, M. Sousa, Crespo, M., Sumanasuriya, S., Yuan, W., Boysen, G., Riisnaes, R., Calcinotto, A., Carreira, S., Goodall, J., Zafeiriou, Z., Bianchini, D., Morilla, A., Morilla, R., Alimonti, A., de Bono, J.S.
Published in Annals of oncology (01.10.2016)
Published in Annals of oncology (01.10.2016)
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Prospective study of genetic mutations in matched tumor and plasma specimens in colorectal cancer patients
Perkins, G., Dukes, J., Yap, T. A., Riisnaes, R., Pope, L., Cassidy, A., Denholm, K. A., Gonzalez de Castro, D., Chau, I., De Bono, J. S.
Published in Journal of clinical oncology (01.02.2011)
Published in Journal of clinical oncology (01.02.2011)
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Phase I trial to determine the dose range for the c-Met inhibitor ARQ 197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule
Yap, T. A., Harris, D., Barriuso, J., Wright, M., Riisnaes, R., Clark, J., Ledaki, I., Savage, R., Chen, T., De Bono, J. S.
Published in Journal of clinical oncology (20.05.2008)
Published in Journal of clinical oncology (20.05.2008)
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