Comparison of daclatasvir resistance barriers on NS5A from hepatitis C virus genotypes 1 to 6: implications for cross-genotype activity
Wang, Chunfu, Jia, Lingling, O'Boyle, 2nd, Donald R, Sun, Jin-Hua, Rigat, Karen, Valera, Lourdes, Nower, Peter, Huang, Xin, Kienzle, Bernadette, Roberts, Susan, Gao, Min, Fridell, Robert A
Published in Antimicrobial agents and chemotherapy (01.09.2014)
Published in Antimicrobial agents and chemotherapy (01.09.2014)
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Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase
LEMM, Julie A, MENGPING LIU, KNIPE, Jay O, COLONNO, Richard, MEANWELL, Nicholas A, KADOW, John F, SANTONE, Kenneth S, ROBERTS, Susan B, MIN GAO, GENTLES, Robert G, MIN DING, VOSS, Stacey, PELOSI, Lenore A, WANG, Ying-Kai, RIGAT, Karen L, MOSURE, Kathleen W, BENDER, John A
Published in Antimicrobial agents and chemotherapy (01.06.2014)
Published in Antimicrobial agents and chemotherapy (01.06.2014)
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Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase
Rigat, Karen L., Lu, Hao, Wang, Ying-Kai, Argyrou, Argyrides, Fanslau, Caroline, Beno, Brett, Wang, Yi, Marcinkeviciene, Jovita, Ding, Min, Gentles, Robert G., Gao, Min, Abell, Lynn M., Roberts, Susan B.
Published in The Journal of biological chemistry (28.11.2014)
Published in The Journal of biological chemistry (28.11.2014)
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Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies
Yeung, Kap-Sun, Beno, Brett R, Parcella, Kyle, Bender, John A, Grant-Young, Katherine A, Nickel, Andrew, Gunaga, Prashantha, Anjanappa, Prakash, Bora, Rajesh Onkardas, Selvakumar, Kumaravel, Rigat, Karen, Wang, Ying-Kai, Liu, Mengping, Lemm, Julie, Mosure, Kathy, Sheriff, Steven, Wan, Changhong, Witmer, Mark, Kish, Kevin, Hanumegowda, Umesh, Zhuo, Xiaoliang, Shu, Yue-Zhong, Parker, Dawn, Haskell, Roy, Ng, Alicia, Gao, Qi, Colston, Elizabeth, Raybon, Joseph, Grasela, Dennis M, Santone, Kenneth, Gao, Min, Meanwell, Nicholas A, Sinz, Michael, Soars, Matthew G, Knipe, Jay O, Roberts, Susan B, Kadow, John F
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase
Zheng, Barbara Zhizhen, D'Andrea, Stanley V., Hanumegowda, Umesh, Knipe, Jay O., Mosure, Kathy, Zhuo, Xiaoliang, Lemm, Julie A., Liu, Mengping, Rigat, Karen L., Wang, Ying-Kai, Fang, Hua, Poronsky, Chris, Cutrone, Jingfang, Wu, Dauh-Rurng, Arunachalam, Pirama Nayagam, Balapragalathan, T.J., Arumugam, Arunachalam, Mathur, Arvind, Meanwell, Nicholas A., Gao, Min, Roberts, Susan B., Kadow, John F.
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
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Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase
Hewawasam, Piyasena, Tu, Yong, Gao, Min, Hanumegowda, Umesh, Knipe, Jay, Lemm, Julie A., Parker, Dawn D., Rigat, Karen L., Roberts, Susan B., Meanwell, Nicholas A., Kadow, John F.
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
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Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus
Zheng, Xiaofan, Hudyma, Thomas W., Martin, Scott W., Bergstrom, Carl, Ding, Min, He, Feng, Romine, Jeffrey, Poss, Michael A., Kadow, John F., Chang, Chong-Hwan, Wan, John, Witmer, Mark R., Morin, Paul, Camac, Daniel M., Sheriff, Steven, Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert, Lemm, Julie, Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore, Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase
Ding, Min, He, Feng, Hudyma, Thomas W., Zheng, Xiaofan, Poss, Michael A., Kadow, John F., Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert A., Lemm, Julie A., Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore A., Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase
Ding, Min, He, Feng, Poss, Michael A., Rigat, Karen L., Wang, Ying-Kai, Roberts, Susan B., Qiu, Dike, Fridell, Robert A., Gao, Min, Gentles, Robert G.
Published in Organic & biomolecular chemistry (07.10.2011)
Published in Organic & biomolecular chemistry (07.10.2011)
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Ligand-induced changes in hepatitis C virus NS5B polymerase structure
Rigat, Karen, Wang, Yi, Hudyma, Thomas W., Ding, Min, Zheng, Xiaofan, Gentles, Robert G., Beno, Brett R., Gao, Min, Roberts, Susan B.
Published in Antiviral research (01.11.2010)
Published in Antiviral research (01.11.2010)
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A homogeneous, solid-phase assay for hepatitis C virus RNA-dependent RNA polymerase
Wang, Ying-Kai, Rigat, Karen L., Roberts, Susan B., Gao, Min
Published in Analytical biochemistry (01.12.2006)
Published in Analytical biochemistry (01.12.2006)
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Development of a Cell-Based High-Throughput Specificity Screen Using a Hepatitis C Virus-Bovine Viral Diarrhea Virus Dual Replicon Assay
O'BOYLE, Donald R, NOWER, Peter T, LEMM, Julie A, VALERA, Lourdes, SUN, Jin-Hua, RIGAT, Karen, COLONNO, Richard, MIN GAO
Published in Antimicrobial Agents and Chemotherapy (01.04.2005)
Published in Antimicrobial Agents and Chemotherapy (01.04.2005)
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De Novo Initiation of RNA Synthesis by the RNA-Dependent RNA Polymerase (NS5B) of Hepatitis C Virus
Luo, G, Hamatake, R K, Mathis, D M, Racela, J, Rigat, K L, Lemm, J, Colonno, R J
Published in Journal of Virology (01.01.2000)
Published in Journal of Virology (01.01.2000)
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Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A
Sun, Jin-Hua, O’Boyle II, Donald R., Fridell, Robert A., Langley, David R., Wang, Chunfu, Roberts, Susan B., Nower, Peter, Johnson, Benjamin M., Moulin, Frederic, Nophsker, Michelle J., Wang, Ying-Kai, Liu, Mengping, Rigat, Karen, Tu, Yong, Hewawasam, Piyasena, Kadow, John, Meanwell, Nicholas A., Cockett, Mark, Lemm, Julie A., Kramer, Melissa, Belema, Makonen, Gao, Min
Published in Nature (London) (12.11.2015)
Published in Nature (London) (12.11.2015)
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Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
Gentles, Robert G., Ding, Min, Bender, John A., Bergstrom, Carl P., Grant-Young, Katharine, Hewawasam, Piyasena, Hudyma, Thomas, Martin, Scott, Nickel, Andrew, Regueiro-Ren, Alicia, Tu, Yong, Yang, Zhong, Yeung, Kap-Sun, Zheng, Xiaofan, Chao, Sam, Sun, Jung-Hui, Beno, Brett R., Camac, Daniel M., Chang, Chong-Hwan, Gao, Mian, Morin, Paul E., Sheriff, Steven, Tredup, Jeff, Wan, John, Witmer, Mark R., Xie, Dianlin, Hanumegowda, Umesh, Knipe, Jay, Mosure, Kathy, Santone, Kenneth S., Parker, Dawn D., Zhuo, Xiaoliang, Lemm, Julie, Liu, Mengping, Pelosi, Lenore, Rigat, Karen, Voss, Stacey, Wang, Yi, Wang, Ying-Kai, Colonno, Richard J., Gao, Min, Roberts, Susan B., Gao, Qi, Ng, Alicia, Meanwell, Nicholas A, Kadow, John F.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor
Parcella, Kyle, Eastman, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A, Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Liu, Mengping, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F
Published in ACS medicinal chemistry letters (13.07.2017)
Published in ACS medicinal chemistry letters (13.07.2017)
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The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase
Eastman, Kyle J., Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A., Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R., Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G., Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A., Soars, Matthew G., Roberts, Susan B., Kadow, John F.
Published in MedChemComm (01.04.2017)
Published in MedChemComm (01.04.2017)
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Structure–Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors
Yeung, Kap-Sun, Beno, Brett R, Mosure, Kathy, Zhu, Juliang, Grant-Young, Katherine A, Parcella, Kyle, Anjanappa, Prakash, Bora, Rajesh Onkardas, Selvakumar, Kumaravel, Wang, Ying-Kai, Fang, Hua, Krause, Rudolph, Rigat, Karen, Liu, Mengping, Lemm, Julie, Sheriff, Steven, Witmer, Mark, Tredup, Jeffrey, Jardel, Adam, Kish, Kevin, Parker, Dawn, Haskell, Roy, Santone, Kenneth, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymeraseThe authors declare no competing interests.Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00636a
Eastman, Kyle J, Parcella, Kyle, Yeung, Kap-Sun, Grant-Young, Katharine A, Zhu, Juliang, Wang, Tao, Zhang, Zhongxing, Yin, Zhiwei, Beno, Brett R, Sheriff, Steven, Kish, Kevin, Tredup, Jeffrey, Jardel, Adam G, Halan, Vivek, Ghosh, Kaushik, Parker, Dawn, Mosure, Kathy, Fang, Hua, Wang, Ying-Kai, Lemm, Julie, Zhuo, Xiaoliang, Hanumegowda, Umesh, Rigat, Karen, Donoso, Maria, Tuttle, Maria, Zvyaga, Tatyana, Haarhoff, Zuzana, Meanwell, Nicholas A, Soars, Matthew G, Roberts, Susan B, Kadow, John F
Year of Publication 20.04.2017
Year of Publication 20.04.2017
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