Selective CB2 receptor agonists. Part 1: The identification of novel ligands through computer-aided drug design (CADD) approaches
Hickey, Eugene R., Zindell, Renee, Cirillo, Pier F., Wu, Lifen, Ermann, Monika, Berry, Angela K., Thomson, David S., Albrecht, Claudia, Gemkow, Mark J., Riether, Doris
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Journal Article
Nonsteroidal Dissociated Glucocorticoid Agonists Containing Azaindoles as Steroid A-Ring Mimetics
Riether, Doris, Harcken, Christian, Razavi, Hossein, Kuzmich, Daniel, Gilmore, Thomas, Bentzien, Jörg, Pack, Edward J, Souza, Donald, Nelson, Richard M, Kukulka, Alison, Fadra, Tazmeen N, Zuvela-Jelaska, Ljiljana, Pelletier, Josephine, Dinallo, Roger, Panzenbeck, Mark, Torcellini, Carol, Nabozny, Gerald H, Thomson, David S
Published in Journal of medicinal chemistry (23.09.2010)
Published in Journal of medicinal chemistry (23.09.2010)
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Journal Article
Reactivity of Functional Groups on the Protein Surface: Development of Epoxide Probes for Protein Labeling
Chen, Gong, Heim, Alexander, Riether, Doris, Yee, Dominic, Milgrom, Yelena, Gawinowicz, Mary Ann, Sames, Dalibor
Published in Journal of the American Chemical Society (09.07.2003)
Published in Journal of the American Chemical Society (09.07.2003)
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Journal Article
Identification of Highly Selective Orexin 1 Receptor Antagonists Driven by Structure-Based Design
Lessel, Uta, Ferrara, Marco, Heine, Niklas, Marelli, Chiara, Carrettoni, Laura, Pfau, Roland, Schmidt, Esther, Riether, Doris
Published in Journal of chemical information and modeling (27.12.2021)
Published in Journal of chemical information and modeling (27.12.2021)
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Journal Article
Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI‑3231, a Well-Characterized Chemical Probe Available for Open Science
Thamm, Sven, Willwacher, Marina K., Aspnes, Gary E., Bretschneider, Tom, Brown, Nicholas F., Buschbom-Helmke, Silke, Fox, Thomas, Gargano, Emanuele M., Grabowski, Daniel, Hoenke, Christoph, Matera, Damian, Mueck, Katja, Peters, Stefan, Reindl, Sophia, Riether, Doris, Schmid, Matthias, Tautermann, Christofer S., Teitelbaum, Aaron M., Trünkle, Cornelius, Veser, Thomas, Winter, Martin, Wortmann, Lars
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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Journal Article
Epigenetic Modification 6‐Methyladenosine Can Impact the Potency and Specificity of siRNA
Rydzik, Anna M., Gottschling, Dirk, Simon, Eric, Skronska‐Wasek, Wioletta, Rippmann, Jörg F., Riether, Doris
Published in Chembiochem : a European journal of chemical biology (02.02.2021)
Published in Chembiochem : a European journal of chemical biology (02.02.2021)
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Journal Article
Identification of Highly Efficacious Glucocorticoid Receptor Agonists with a Potential for Reduced Clinical Bone Side Effects
Harcken, Christian, Riether, Doris, Kuzmich, Daniel, Liu, Pingrong, Betageri, Raj, Ralph, Mark, Emmanuel, Michel, Reeves, Jonathan T, Berry, Angela, Souza, Donald, Nelson, Richard M, Kukulka, Alison, Fadra, Tazmeen N, Zuvela-Jelaska, Ljiljana, Dinallo, Roger, Bentzien, Jörg, Nabozny, Gerald H, Thomson, David S
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Journal Article
Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)
Takahashi, Hidenori, Riether, Doris, Bartolozzi, Alessandra, Bosanac, Todd, Berger, Valentina, Binetti, Ralph, Broadwater, John, Chen, Zhidong, Crux, Rebecca, De Lombaert, Stéphane, Dave, Rajvee, Dines, Jonathon A, Fadra-Khan, Tazmeen, Flegg, Adam, Garrigou, Michael, Hao, Ming-Hong, Huber, John, Hutzler, J. Matthew, Kerr, Steven, Kotey, Adrian, Liu, Weimin, Lo, Ho Yin, Loke, Pui Leng, Mahaney, Paige E, Morwick, Tina M, Napier, Spencer, Olague, Alan, Pack, Edward, Padyana, Anil K, Thomson, David S, Tye, Heather, Wu, Lifen, Zindell, Renee M, Abeywardane, Asitha, Simpson, Thomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Discovery and optimization of oxadiazole-based FLAP inhibitors
Bartolozzi, Alessandra, Abeywardane, Asitha, Bosanac, Todd, Broadwater, John A., Chen, Zhidong, Hutzler, J. Matthew, Huber, John D., Nemoto, Peter, Olague, Alan, Riether, Doris, Simpson, Tom, Takahashi, Hidenori, Wu, Lifen, Zhang, Yunlong, Zindell, Renee M.
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
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Journal Article
Selective CB2 receptor agonists. Part 3: The optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model
Bartolozzi, Alessandra, Cirillo, Pier Francesco, Berry, Angela K., Hickey, Eugene R., Thomson, David S., Wu, Lifen, Zindell, Renee, Albrecht, Claudia, Ceci, Angelo, Gemkow, Mark J., Nagaraja, Nelamangala V., Romig, Helmut, Sauer, Achim, Riether, Doris
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Journal Article
Selective CB2 receptor agonists. Part 2: Structure–activity relationship studies and optimization of proline-based compounds
Riether, Doris, Zindell, Renee, Wu, Lifen, Betageri, Raj, Jenkins, James E., Khor, Someina, Berry, Angela K., Hickey, Eugene R., Ermann, Monika, Albrecht, Claudia, Ceci, Angelo, Gemkow, Mark J., Nagaraja, Nelamangala V., Romig, Helmut, Sauer, Achim, Thomson, David S.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Journal Article
Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore
Razavi, Hossein, Riether, Doris, Harcken, Christian, Bentzien, Joerg, Dinallo, Roger M., Souza, Donald, Nelson, Richard M., Kukulka, Alison, Fadra-Khan, Tazmeen N., Pack, Edward J., Zuvela-Jelaska, Ljiljana, Pelletier, Josephine, Panzenbeck, Mark, Torcellini, Carol A., Proudfoot, John R., Nabozny, Gerald H., Thomson, David S.
Published in Bioorganic & medicinal chemistry letters (15.04.2014)
Published in Bioorganic & medicinal chemistry letters (15.04.2014)
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Journal Article
Optimization of Drug-Like Properties of Nonsteroidal Glucocorticoid Mimetics and Identification of a Clinical Candidate
Harcken, Christian, Riether, Doris, Liu, Pingrong, Razavi, Hossein, Patel, Usha, Lee, Thomas, Bosanac, Todd, Ward, Yancey, Ralph, Mark, Chen, Zhidong, Souza, Donald, Nelson, Richard M, Kukulka, Alison, Fadra-Khan, Tazmeen N, Zuvela-Jelaska, Ljiljana, Patel, Mita, Thomson, David S, Nabozny, Gerald H
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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Journal Article
1,4-Diazepane compounds as potent and selective CB2 agonists: Optimization of metabolic stability
Riether, Doris, Wu, Lifen, Cirillo, Pier F., Berry, Angela, Walker, Edward R., Ermann, Monika, Noya-Marino, Beatriz, Jenkins, James E., Albaugh, Dan, Albrecht, Claudia, Fisher, Michael, Gemkow, Mark J., Grbic, Heather, Löbbe, Sabine, Möller, Clemens, O’Shea, Kathy, Sauer, Achim, Shih, Daw-Tsun, Thomson, David S.
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
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Journal Article
Morpholine containing CB2 selective agonists
ZINDELL, Renée, RIETHER, Doris, THOMSON, David, BOSANAC, Todd, BERRY, Angela, GEMKOW, Mark J, EBNETH, Andreas, LÖBBE, Sabine, RAYMOND, Ernest L, THOME, Diane, SHIH, Daw-Tsun
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Journal Article
NOVEL (CYANO-DIMETHYL-METHYL)-ISOXAZOLES AND -[1,3,4]THIADIAZOLES
BINDER FLORIAN, DOODS HENRI, NICHOLSON JANET RACHEL, RIETHER DORIS, MUELLER STEPHAN GEORG, SAUER ACHIM
Year of Publication 21.01.2016
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Year of Publication 21.01.2016
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