The impact of information about different absolute benefits and harms on intention to participate in colorectal cancer screening: A think-aloud study and online randomised experiment
Usher-Smith, Juliet A, Mills, Katie M, Riedinger, Christiane, Saunders, Catherine L, Helsingen, Lise M, Lytvyn, Lyubov, Buskermolen, Maaike, Lansdorp-Vogelaar, Iris, Bretthauer, Michael, Guyatt, Gordon, Griffin, Simon J
Published in PloS one (16.02.2021)
Published in PloS one (16.02.2021)
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Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency
Hardcastle, Ian R, Liu, Junfeng, Valeur, Eric, Watson, Anna, Ahmed, Shafiq U, Blackburn, Timothy J, Bennaceur, Karim, Clegg, William, Drummond, Catherine, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Gruber, Jan, Haggerty, Karen, Harrington, Ross W, Hutton, Claire, Kemp, Stuart, Lu, Xiaohong, McDonnell, James M, Newell, David R, Noble, Martin E. M, Payne, Sara L, Revill, Charlotte H, Riedinger, Christiane, Xu, Qing, Lunec, John
Published in Journal of medicinal chemistry (10.03.2011)
Published in Journal of medicinal chemistry (10.03.2011)
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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction
Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction
Riedinger, Christiane, Endicott, Jane A, Kemp, Stuart J, Smyth, Lynette A, Watson, Anna, Valeur, Eric, Golding, Bernard T, Griffin, Roger J, Hardcastle, Ian R, Noble, Martin E, McDonnell, James M
Published in Journal of the American Chemical Society (26.11.2008)
Published in Journal of the American Chemical Society (26.11.2008)
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Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12
Riedinger, Christiane, Boehringer, Jonas, Trempe, Jean-Francois, Lowe, Edward D., Brown, Nicholas R., Gehring, Kalle, Noble, Martin E.M., Gordon, Colin, Endicott, Jane A.
Published in The Journal of biological chemistry (29.10.2010)
Published in The Journal of biological chemistry (29.10.2010)
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The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant
Anil, Burcu, Riedinger, Christiane, Endicott, Jane A., Noble, Martin E. M.
Published in Acta crystallographica. Section D, Biological crystallography. (01.08.2013)
Published in Acta crystallographica. Section D, Biological crystallography. (01.08.2013)
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Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation
Boehringer, Jonas, Riedinger, Christiane, Paraskevopoulos, Konstantinos, Johnson, Eachan O D, Lowe, Edward D, Khoudian, Christina, Smith, Dominique, Noble, Martin E M, Gordon, Colin, Endicott, Jane A
Published in Biochemical journal (15.11.2012)
Published in Biochemical journal (15.11.2012)
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MDM2-p53 protein–protein interaction inhibitors: A-ring substituted isoindolinones
Watson, Anna F., Liu, Junfeng, Bennaceur, Karim, Drummond, Catherine J., Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Haggerty, Karen, Lu, Xiaohong, McDonnell, James M., Newell, David R., Noble, Martin E.M., Revill, Charlotte H., Riedinger, Christiane, Xu, Qing, Zhao, Yan, Lunec, John, Hardcastle, Ian R.
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Understanding Small-Molecule Binding to MDM2: Insights into Structural Effects of Isoindolinone Inhibitors from NMR Spectroscopy
Riedinger, Christiane, Noble, Martin E., Wright, David J., Mulks, Florian, Hardcastle, Ian R., Endicott, Jane A., McDonnell, James M.
Published in Chemical biology & drug design (01.05.2011)
Published in Chemical biology & drug design (01.05.2011)
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Abstract A140: Identification of substituted isoindolinones as potent inhibitors of the MDM2-p53 protein-protein interaction
Watson, Anna, Liu, Junfeng, Armstrong, Elizabeth, Blackburn, Timothy, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Lu, Xiaohong, Newell, David R., Noble, Martin E.M., Riedinger, Christiane, Lunec, John, Hardcastle, Ian R.
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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NEW THERAPEUTIC AGENTS
NOBLE, Martin, RIEDINGER, Christiane, HARDCASTLE, Ian, Robert, VALEUR, Eric, GOLDING, Bernard, Thomas, WATSON, Anna, Frances, GRIFFIN, Roger John
Year of Publication 04.12.2019
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Year of Publication 04.12.2019
Patent
NEW THERAPEUTIC AGENTS
NOBLE, Martin, RIEDINGER, Christiane, HARDCASTLE, Ian, Robert, VALEUR, Eric, GOLDING, Bernard, Thomas, WATSON, Anna, Frances, GRIFFIN, Roger John
Year of Publication 30.10.2019
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Year of Publication 30.10.2019
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Therapeutic agents
Valeur, Eric, Griffin, Roger John, Watson, Anna Frances, Riedinger, Christiane, Golding, Bernard Thomas, Hardcastle, Ian Robert, Noble, Martin
Year of Publication 17.09.2019
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Year of Publication 17.09.2019
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ISOINDOLIN-1-ONE DERIVATIVES
GOLDING, BERNARD THOMAS, GRIFFIN, ROGER JOHN, RIEDINGER, CHRISTIANE, VALEUR, ERIC, WATSON, ANNA FRANCES, HARDCASTLE, IAN ROBERT, NOBLE, MARTIN
Year of Publication 20.08.2019
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Year of Publication 20.08.2019
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THERAPEUTIC AGENTS
HARDCASTLE, Ian Robert, NOBLE, Martin, WATSON, Anna Frances, RIEDINGER, Christiane, VALEUR, Eric, GOLDING, Bernard Thomas, GRIFFIN, Roger John
Year of Publication 03.05.2018
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Year of Publication 03.05.2018
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