Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Richter, Hans G.F., Benson, G.M., Bleicher, K.H., Blum, D., Chaput, E., Clemann, N., Feng, S., Gardes, C., Grether, U., Hartman, P., Kuhn, B., Martin, R.E., Plancher, J.-M., Rudolph, M.G., Schuler, F., Taylor, S.
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
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Journal Article
Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes
Richter, Hans G.F., Benson, Gregory M., Blum, Denise, Chaput, Evelyne, Feng, Song, Gardes, Christophe, Grether, Uwe, Hartman, Peter, Kuhn, Bernd, Martin, Rainer E., Plancher, Jean-Marc, Rudolph, Markus G., Schuler, Franz, Taylor, Sven, Bleicher, Konrad H.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists
Dehmlow, Henrietta, Alvarez Sánchez, Rubén, Bachmann, Stephan, Bissantz, Caterina, Bliss, Fritz, Conde-Knape, Karin, Graf, Martin, Martin, Rainer E., Obst Sander, Ulrike, Raab, Susanne, Richter, Hans G.F., Sewing, Sabine, Sprecher, Urs, Ullmer, Christoph, Mattei, Patrizio
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Journal Article
2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)
Martin, Rainer E., Bissantz, Caterina, Gavelle, Olivier, Kuratli, Christoph, Dehmlow, Henrietta, Richter, Hans G. F., Obst Sander, Ulrike, Erickson, Shawn D., Kim, Kyungjin, Pietranico-Cole, Sherrie Lynn, Alvarez-Sánchez, Rubén, Ullmer, Christoph
Published in ChemMedChem (01.04.2013)
Published in ChemMedChem (01.04.2013)
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Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2 -a]pyrazines as potent and selective 5-HT2C receptor agonists
RICHTER, Hans G. F, ADAMS, D. R, KNIGHT, A. R, MALCOLM, C. S, MATTEI, P, MISRA, A, MIZRAHI, J, MONCK, N. J. T, PLANCHER, J.-M, ROEVER, S, ROFFEY, J. R. A, TAYLOR, S, BENARDEAU, A, VICKERS, S. P, BICKERDIKE, M. J, BENTLEY, J. M, BLENCH, T. J, CLIFFE, I. A, DOURISH, C, HEBEISEN, P, KENNETT, G. A
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Journal Article
Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2- a]pyrazines as potent and selective 5-HT 2C receptor agonists
Richter, Hans G.F., Adams, D.R., Benardeau, A., Bickerdike, M.J., Bentley, J.M., Blench, T.J., Cliffe, I.A., Dourish, C., Hebeisen, P., Kennett, G.A., Knight, A.R., Malcolm, C.S., Mattei, P., Misra, A., Mizrahi, J., Monck, N.J.T., Plancher, J.-M., Roever, S., Roffey, J.R.A., Taylor, S., Vickers, S.P.
Published in Bioorganic & medicinal chemistry letters (2006)
Published in Bioorganic & medicinal chemistry letters (2006)
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Journal Article
Design, Synthesis, and Evaluation of 2β-Alkenyl Penam Sulfone Acids as Inhibitors of β-Lactamases
Richter, Hans G. F, Angehrn, Peter, Hubschwerlen, Christian, Kania, Malgosia, Page, Malcolm G. P, Specklin, Jean-Luc, Winkler, Fritz K
Published in Journal of medicinal chemistry (13.09.1996)
Published in Journal of medicinal chemistry (13.09.1996)
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Journal Article
Synthesis and Structure−Activity Relationship of (Lactamylvinyl)cephalosporins Exhibiting Activity against Staphylococci, Pneumococci, and Enterococci
Heinze-Krauss, Ingrid, Angehrn, Peter, Guerry, Philippe, Hebeisen, Paul, Hubschwerlen, Christian, Kompis, Ivan, Page, Malcolm G. P, Richter, Hans G. F, Runtz, Valérie, Stalder, Henri, Weiss, Urs, Wei, Chung-Chen
Published in Journal of medicinal chemistry (26.04.1996)
Published in Journal of medicinal chemistry (26.04.1996)
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Journal Article
ANTIMICROBIAL COMPOSITION
HEINZE-KRAUSS, INGRID, ANGEHRN, PETER, RICHTER, HANS G.F, PAGE, MALCOLM
Year of Publication 28.08.2007
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Year of Publication 28.08.2007
Patent
Propenyl cephalosporin derivatives
PETER ANGEHRN, ERWIN GOETSCHI, INGRID HEINZE-KRAUSS, HANS G.F. RICHTER
Year of Publication 05.06.2003
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Year of Publication 05.06.2003
Patent