Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning
Echle, Amelie, Grabsch, Heike Irmgard, Quirke, Philip, van den Brandt, Piet A., West, Nicholas P., Hutchins, Gordon G.A., Heij, Lara R., Tan, Xiuxiang, Richman, Susan D., Krause, Jeremias, Alwers, Elizabeth, Jenniskens, Josien, Offermans, Kelly, Gray, Richard, Brenner, Hermann, Chang-Claude, Jenny, Trautwein, Christian, Pearson, Alexander T., Boor, Peter, Luedde, Tom, Gaisa, Nadine Therese, Hoffmeister, Michael, Kather, Jakob Nikolas
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2020)
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Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies
Venderbosch, Sabine, Nagtegaal, Iris D, Maughan, Tim S, Smith, Christopher G, Cheadle, Jeremy P, Fisher, David, Kaplan, Richard, Quirke, Philip, Seymour, Matthew T, Richman, Susan D, Meijer, Gerrit A, Ylstra, Bauke, Heideman, Danielle A M, de Haan, Anton F J, Punt, Cornelis J A, Koopman, Miriam
Published in Clinical cancer research (15.10.2014)
Published in Clinical cancer research (15.10.2014)
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KRAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated With Poor Prognosis but Do Not Preclude Benefit From Oxaliplatin or Irinotecan: Results From the MRC FOCUS Trial
Richman, Susan D, Seymour, Matthew T, Chambers, Philip, Elliott, Faye, Daly, Catherine L, Meade, Angela M, Taylor, Graham, Barrett, Jennifer H, Quirke, Philip
Published in Journal of clinical oncology (10.12.2009)
Published in Journal of clinical oncology (10.12.2009)
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A robust multiplex immunofluorescence and digital pathology workflow for the characterisation of the tumour immune microenvironment
Viratham Pulsawatdi, Amélie, Craig, Stephanie G., Bingham, Victoria, McCombe, Kris, Humphries, Matthew P., Senevirathne, Seedevi, Richman, Susan D., Quirke, Phil, Campo, Leticia, Domingo, Enric, Maughan, Timothy S., James, Jacqueline A., Salto‐Tellez, Manuel
Published in Molecular oncology (01.10.2020)
Published in Molecular oncology (01.10.2020)
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Journal Article
The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation testing
Srihar, Kanishta, Gusnanto, Arief, Richman, Susan D., West, Nicholas P., Galvin, Leanne, Bottomley, Daniel, Hemmings, Gemma, Glover, Amy, Natarajan, Subaashini, Miller, Rebecca, Arif, Sameira, Rossington, Hannah, Dunwell, Thomas L., Dailey, Simon C., Fontarum, Gracielle, George, Agnes, Wu, Winnie, Quirke, Phil, Wood, Henry M.
Published in Scientific reports (19.09.2024)
Published in Scientific reports (19.09.2024)
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Predictive Biomarkers of Chemotherapy Efficacy in Colorectal Cancer: Results From the UK MRC FOCUS Trial
Braun, Michael S, Richman, Susan D, Quirke, Philip, Daly, Catherine, Adlard, Julian W, Elliott, Faye, Barrett, Jennifer H, Selby, Peter, Meade, Angela M, Stephens, Richard J, Parmar, Mahesh K B, Seymour, Matthew T
Published in Journal of clinical oncology (01.06.2008)
Published in Journal of clinical oncology (01.06.2008)
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Journal Article
Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial
BRAUN, Michael S, RICHMAN, Susan D, THOMPSON, Lindsay, DALY, Catherine L, MEADE, Angela M, ADLARD, Julian W, ALLAN, James M, PARMAR, Mahesh K. B, QUIRKE, Philip, SEYMOUR, Matthew T
Published in Journal of clinical oncology (20.11.2009)
Published in Journal of clinical oncology (20.11.2009)
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Journal Article
Results of the UK NEQAS for Molecular Genetics reference sample analysis
Richman, Susan D, Fairley, Jennifer, Hall, Jacqueline A, Nataraj, Nakul, Bhide, Mrudul, Lau, Aron, Norman, Kara L, Deans, Zandra C
Published in Journal of clinical pathology (01.11.2018)
Published in Journal of clinical pathology (01.11.2018)
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Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA
Dunwell, Thomas L., Dailey, Simon C., Ottestad, Anine L., Yu, Jihang, Becker, Philipp W., Scaife, Sarah, Richman, Susan D., Wood, Henry M., Slaney, Hayley, Bottomley, Daniel, Yang, Xiangsheng, Xiao, Hui, Wahl, Sissel G. F., Grønberg, Bjørn H., Dai, Hongyan, Fu, Guoliang
Published in Scientific reports (04.02.2021)
Published in Scientific reports (04.02.2021)
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Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy
Lafarge, Maxime W., Domingo, Enric, Sirinukunwattana, Korsuk, Wood, Ruby, Samuel, Leslie, Murray, Graeme, Richman, Susan D., Blake, Andrew, Sebag-Montefiore, David, Gollins, Simon, Klieser, Eckhard, Neureiter, Daniel, Huemer, Florian, Greil, Richard, Dunne, Philip, Quirke, Philip, Weiss, Lukas, Rittscher, Jens, Maughan, Tim, Koelzer, Viktor H.
Published in NPJ precision oncology (09.04.2024)
Published in NPJ precision oncology (09.04.2024)
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Intra-tumoral heterogeneity of KRAS and BRAF mutation status in patients with advanced colorectal cancer (aCRC) and cost-effectiveness of multiple sample testing
Richman, Susan D, Chambers, Philip, Seymour, Matthew T, Daly, Catherine, Grant, Sophie, Hemmings, Gemma, Quirke, Philip
Published in Analytical cellular pathology (Amsterdam) (01.01.2011)
Published in Analytical cellular pathology (Amsterdam) (01.01.2011)
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Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning
Sirinukunwattana, Korsuk, Domingo, Enric, Richman, Susan D, Redmond, Keara L, Blake, Andrew, Verrill, Clare, Leedham, Simon J, Chatzipli, Aikaterini, Hardy, Claire, Whalley, Celina M, Wu, Chieh-hsi, Beggs, Andrew D, McDermott, Ultan, Dunne, Philip D, Meade, Angela, Walker, Steven M, Murray, Graeme I, Samuel, Leslie, Seymour, Matthew, Tomlinson, Ian, Quirke, Phil, Maughan, Timothy, Rittscher, Jens, Koelzer, Viktor H
Published in Gut (01.03.2021)
Published in Gut (01.03.2021)
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Journal Article
HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials
Richman, Susan D, Southward, Katie, Chambers, Philip, Cross, Debra, Barrett, Jennifer, Hemmings, Gemma, Taylor, Morag, Wood, Henry, Hutchins, Gordon, Foster, Joseph M, Oumie, Assa, Spink, Karen G, Brown, Sarah R, Jones, Marc, Kerr, David, Handley, Kelly, Gray, Richard, Seymour, Matthew, Quirke, Philip
Published in The Journal of pathology (01.03.2016)
Published in The Journal of pathology (01.03.2016)
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Prediction of the response of colorectal cancer to systemic therapy
Adlard, Julian W, Richman, Susan D, Seymour, Matthew T, Quirke, Phil
Published in The lancet oncology (01.02.2002)
Published in The lancet oncology (01.02.2002)
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Journal Article
Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia
Craig, Stephanie G., Humphries, Matthew P., Alderdice, Matthew, Bingham, Victoria, Richman, Susan D., Loughrey, Maurice B., Coleman, Helen G., Viratham-Pulsawatdi, Amelie, McCombe, Kris, Murray, Graeme I., Blake, Andrew, Domingo, Enric, Robineau, James, Brown, Louise, Fisher, David, Seymour, Matthew T., Quirke, Phil, Bankhead, Peter, McQuaid, Stephen, Lawler, Mark, McArt, Darragh G., Maughan, Tim S., James, Jacqueline A., Salto-Tellez, Manuel
Published in British journal of cancer (13.10.2020)
Published in British journal of cancer (13.10.2020)
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Journal Article
Prospective patient stratification into robust cancer‐cell intrinsic subtypes from colorectal cancer biopsies
Alderdice, Matthew, Richman, Susan D, Gollins, Simon, Stewart, James P, Hurt, Chris, Adams, Richard, McCorry, Amy MB, Roddy, Aideen C, Vimalachandran, Dale, Isella, Claudio, Medico, Enzo, Maughan, Tim, McArt, Darragh G, Lawler, Mark, Dunne, Philip D
Published in The Journal of pathology (01.05.2018)
Published in The Journal of pathology (01.05.2018)
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Inhibition of WEE1 Is Effective in TP53 - and RAS -Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring
Seligmann, Jenny F, Fisher, David J, Brown, Louise C, Adams, Richard A, Graham, Janet, Quirke, Philip, Richman, Susan D, Butler, Rachel, Domingo, Enric, Blake, Andrew, Yates, Emma, Braun, Michael, Collinson, Fiona, Jones, Rob, Brown, Ewan, de Winton, Emma, Humphrey, Timothy C, Parmar, Mahesh, Kaplan, Richard, Wilson, Richard H, Seymour, Matthew, Maughan, Timothy S
Published in Journal of clinical oncology (20.11.2021)
Published in Journal of clinical oncology (20.11.2021)
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Journal Article
FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing
Richman, Susan D, Hemmings, Gemma, Roberts, Helen, Gallop, Niall, Dodds, Rachel, Wilkinson, Lyndsay, Davis, Jonathan, White, Rhian, Yates, Emma, Jasani, Bharat, Brown, Louise, Maughan, Tim S, Butler, Rachel, Quirke, Philip, Adams, Richard
Published in Journal of clinical pathology (01.08.2023)
Published in Journal of clinical pathology (01.08.2023)
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Evaluation of CD3 and CD8 T-Cell Immunohistochemistry for Prognostication and Prediction of Benefit From Adjuvant Chemotherapy in Early-Stage Colorectal Cancer Within the QUASAR Trial
Williams, Christopher J M, Gray, Richard, Hills, Robert K, Shires, Michael, Zhang, Liping, Zhao, Zuo, Gardner, Tracie, Sapanara, Nancy, Xu, Xiao-Meng, Bai, Isaac, Yan, Dongyao, Muranyi, Andrea, Dance, Sarah, Aghaei, Faranak, Hemmings, Gemma, Hale, Michael, Kurkure, Uday, Guetter, Christoph, Richman, Susan D, Hutchins, Gordon, Seligmann, Jenny F, West, Nicholas P, Singh, Shalini, Shanmugam, Kandavel, Quirke, Philip
Published in Journal of clinical oncology (10.10.2024)
Published in Journal of clinical oncology (10.10.2024)
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RAS screening in colorectal cancer: a comprehensive analysis of the results from the UK NEQAS colorectal cancer external quality assurance schemes (2009–2016)
Richman, Susan D., Fairley, Jennifer, Butler, Rachel, Deans, Zandra C.
Published in Virchows Archiv : an international journal of pathology (01.12.2017)
Published in Virchows Archiv : an international journal of pathology (01.12.2017)
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