Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer
Scott, Fiona, Fala, Angela M., Pennicott, Lewis E., Reuillon, Tristan D., Massirer, Katlin B., Elkins, Jonathan M., Ward, Simon E.
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
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Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery
Scott, Fiona, Fala, Angela M., Takarada, Jessica E., Ficu, Mihaela P., Pennicott, Lewis E., Reuillon, Tristan D., Couñago, Rafael M., Massirer, Katlin B., Elkins, Jonathan M., Ward, Simon E.
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
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Journal Article
Identification and Characterization of an Irreversible Inhibitor of CDK2
Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E.M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.
Published in Chemistry & biology (17.09.2015)
Published in Chemistry & biology (17.09.2015)
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Journal Article
AiZynth impact on medicinal chemistry practice at AstraZeneca
Shields, Jason D, Howells, Rachel, Lamont, Gillian, Leilei, Yin, Madin, Andrew, Reimann, Christopher E, Rezaei, Hadi, Reuillon, Tristan, Smith, Bryony, Thomson, Clare, Zheng, Yuting, Ziegler, Robert E
Published in MedChemComm (24.04.2024)
Published in MedChemComm (24.04.2024)
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Journal Article
Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL‑1
Demin, Samuël, Peschiulli, Aldo, Velter, Adriana I., Vos, Ann, De Boeck, Benoît, Miller, Bradley, Rombouts, Frederik J. R., Reuillon, Tristan, Lento, William, Blanco, Maria Dominguez, Jouffroy, Matthieu, Steyvers, Helena, Bekkers, Mariette, Altrocchi, Cristina, Pietrak, Beth, Koo, Seong Joo, Szewczuk, Lawrence, Attar, Ricardo, Philippar, Ulrike
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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Journal Article
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor
Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian, Harnor, Suzannah J., Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P., Martin, Nick C., Myers, Stephanie, Newell, David R., Noble, Richard A., Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A., Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
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MCL-1의 억제제로서의 거대환식 인돌 유도체
ROMBOUTS FREDERIK JAN RITA, VELTER ADRIANA INGRID, VOS ANN MARLEEN, REUILLON TRISTAN, PESCHIULLI ALDO
Year of Publication 25.10.2022
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Year of Publication 25.10.2022
Patent
Abstract 4210: Screening of kinase focused libraries for the identification of Greatwall inhibitors
Reuillon, Tristan D., Walker, Sarah, Grand, Darren Le, Ward, Simon E., Wahab, Ben, Rajasekaran, Mohan B., Hochegger, Helfrid, Oliver, Antony W.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4
Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Tucker, Julie A., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine
Published in European journal of medicinal chemistry (15.09.2019)
Published in European journal of medicinal chemistry (15.09.2019)
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치환된 1,2-디아미노 헤테로사이클릭 화합물 유도체의 제조 및 그의 약제로서의 용도
KHOO JA HEOUK, TURNER PENELOPE, BAEK KI SEON, CHOI SOONGYU, PARK YOUNG WHAN, LE GRAND DARREN, WEST RYAN, WARD SIMON, MARAMAI SAMUELE, REUILLON TRISTAN
Year of Publication 15.01.2024
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Year of Publication 15.01.2024
Patent
AMPA 수용체 기능을 조절하는 화합물
VILLALONGA BARBER CAROLINA, PORTER RODERICK ALAN, WARD SIMON, BESWICK PAUL, REUILLON TRISTAN, PENNICOTT LEWIS, CHUCKOWREE IRINA
Year of Publication 11.11.2020
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Year of Publication 11.11.2020
Patent
Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity
Sheldrake, Helen M, Travica, Sandra, Johansson, Inger, Loadman, Paul M, Sutherland, Mark, Elsalem, Lina, Illingworth, Nicola, Cresswell, Alexander J, Reuillon, Tristan, Shnyder, Steven D, Mkrtchian, Souren, Searcey, Mark, Ingelman-Sundberg, Magnus, Patterson, Laurence H, Pors, Klaus
Published in Journal of medicinal chemistry (08.08.2013)
Published in Journal of medicinal chemistry (08.08.2013)
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Journal Article
Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355
Rombouts, Frederik J., William, Lento, Velter, Ingrid, Vos, Ann, Peschiulli, Aldo, Tristan, Reuillon, Blanco, Maria Dominguez, Jouffroy, Matthieu, McQueen, Lisa, Steyvers, Helena, Bekkers, Mariette, Altrocchi, Cristina, Pietrak, Beth, Koo, Seong Joo, Szewczuk, Lawrence, Walker, David, Packman, Kathryn, Bueters, Ruud, Vinken, Petra, Johnson, Amy, Attar, Ricardo, Philippar, Ulrike
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatasesElectronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03612g
Reuillon, Tristan, Alhasan, Sari F, Beale, Gary S, Bertoli, Annalisa, Brennan, Alfie, Cano, Celine, Reeves, Helen L, Newell, David R, Golding, Bernard T, Miller, Duncan C, Griffin, Roger J
Year of Publication 21.03.2016
Year of Publication 21.03.2016
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Journal Article
Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases
Reuillon, Tristan, Alhasan, Sari F., Beale, Gary S., Bertoli, Annalisa, Brennan, Alfie, Cano, Celine, Reeves, Helen L., Newell, David R., Golding, Bernard T., Miller, Duncan C., Griffin, Roger J.
Published in Chemical science (Cambridge) (21.04.2016)
Published in Chemical science (Cambridge) (21.04.2016)
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Journal Article
Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03612g
Reuillon, Tristan, Alhasan, Sari F., Beale, Gary S., Bertoli, Annalisa, Brennan, Alfie, Cano, Celine, Reeves, Helen L., Newell, David R., Golding, Bernard T., Miller, Duncan C., Griffin, Roger J.
Published in Chemical science (Cambridge) (11.01.2016)
Published in Chemical science (Cambridge) (11.01.2016)
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Journal Article
Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groupsElectronic supplementary information (ESI) available: Experimental procedures and analytical data. See DOI: 10.1039/c2ob26057c
Reuillon, Tristan, Bertoli, Annalisa, Griffin, Roger J, Miller, Duncan C, Golding, Bernard T
Year of Publication 30.08.2012
Year of Publication 30.08.2012
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