Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure
Milite, Ciro, Feoli, Alessandra, Horton, John R, Rescigno, Donatella, Cipriano, Alessandra, Pisapia, Vincenzo, Viviano, Monica, Pepe, Giacomo, Amendola, Giorgio, Novellino, Ettore, Cosconati, Sandro, Cheng, Xiaodong, Castellano, Sabrina, Sbardella, Gianluca
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
Iannelli, Giulia, Milite, Ciro, Marechal, Nils, Cura, Vincent, Bonnefond, Luc, Troffer-Charlier, Nathalie, Feoli, Alessandra, Rescigno, Donatella, Wang, Yalong, Cipriano, Alessandra, Viviano, Monica, Bedford, Mark T., Cavarelli, Jean, Castellano, Sabrina, Sbardella, Gianluca
Published in Journal of medicinal chemistry (08.09.2022)
Published in Journal of medicinal chemistry (08.09.2022)
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A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery
Viviano, Monica, Milite, Ciro, Rescigno, Donatella, Castellano, Sabrina, Sbardella, Gianluca
Published in RSC advances (01.01.2015)
Published in RSC advances (01.01.2015)
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The emerging role of lysine methyltransferase SETD8 in human diseases
Milite, Ciro, Feoli, Alessandra, Viviano, Monica, Rescigno, Donatella, Cianciulli, Agostino, Balzano, Amodio Luca, Mai, Antonello, Castellano, Sabrina, Sbardella, Gianluca
Published in Clinical epigenetics (22.09.2016)
Published in Clinical epigenetics (22.09.2016)
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ALK5 억제제로서 피리다진일 아미노 유도체
PALA DANIELE, PIZZIRANI DANIELA, GUARIENTO SARA, RONCHI PAOLO, SEMERARO TERESA, RESCIGNO DONATELLA, BRUNO PAOLO
Year of Publication 20.05.2024
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Year of Publication 20.05.2024
Patent
Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors
Milite, Ciro, Feoli, Alessandra, Viviano, Monica, Rescigno, Donatella, Mai, Antonello, Castellano, Sabrina, Sbardella, Gianluca
Published in ChemMedChem (19.08.2016)
Published in ChemMedChem (19.08.2016)
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Design, Synthesis, and Activity of a Novel Series of Pyridazine-Based ALK5 Inhibitors
Pala, Daniele, Ronchi, Paolo, Rescigno, Donatella, Bertani, Barbara, Capelli, Anna Maria, Guariento, Sara, Marchini, Gessica, Milioli, Marco, Cesari, Nicola, Federico, Giuseppina, Grandi, Andrea, Stellari, Franco F., Fernandez, Sergio Xanxo, Pappani, Alice, Venturi, Luca, Biagetti, Matteo, Civelli, Maurizio, Semeraro, Teresa, Bianchi, Federica, Trist, Iuni M. L., Remelli, Rosaria, Armani, Elisabetta, Pizzirani, Daniela
Published in ACS medicinal chemistry letters (23.10.2024)
Published in ACS medicinal chemistry letters (23.10.2024)
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A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discoveryElectronic supplementary information (ESI) available: Copies of 1H, 13C NMR spectra of synthesized compounds. See DOI: 10.1039/c4ra13392g
Viviano, Monica, Milite, Ciro, Rescigno, Donatella, Castellano, Sabrina, Sbardella, Gianluca
Year of Publication 03.12.2014
Year of Publication 03.12.2014
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PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS
PIZZIRANI, Daniela, RONCHI, Paolo, PALA, Daniele, RESCIGNO, Donatella
Year of Publication 06.09.2024
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Year of Publication 06.09.2024
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PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS
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Year of Publication 31.07.2024
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Year of Publication 31.07.2024
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PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS
PIZZIRANI, Daniela, RONCHI, Paolo, GUARIENTO, Sara, PALA, Daniele, BRUNO, Paolo, SEMERARO, Teresa, RESCIGNO, Donatella
Year of Publication 02.05.2024
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Year of Publication 02.05.2024
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PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
PIZZIRANI, Daniela, RONCHI, Paolo, GUARIENTO, Sara, PALA, Daniele, BRUNO, Paolo, RESCIGNO, Donatella, BIAGETTI, Matteo, BERTANI, Barbara
Year of Publication 11.04.2024
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Year of Publication 11.04.2024
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PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
PIZZIRANI, Daniela, RONCHI, Paolo, GUARIENTO, Sara, PALA, Daniele, BRUNO, Paolo, RESCIGNO, Donatella, BIAGETTI, Matteo, BERTANI, Barbara
Year of Publication 01.11.2023
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Year of Publication 01.11.2023
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PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS
SEMERARO, TERESA, GUARIENTO, SARA, RONCHI, PAOLO, BRUNO, PAOLO, RESCIGNO, DONATELLA, PALA, DANIELE, PIZZIRANI, DANIELA
Year of Publication 30.03.2023
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Year of Publication 30.03.2023
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PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS
PIZZIRANI, Daniela, RONCHI, Paolo, GUARIENTO, Sara, PALA, Daniele, BRUNO, Paolo, SEMERARO, Teresa, RESCIGNO, Donatella
Year of Publication 30.03.2023
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Year of Publication 30.03.2023
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PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
PIZZIRANI, Daniela, RONCHI, Paolo, GUARIENTO, Sara, PALA, Daniele, BRUNO, Paolo, RESCIGNO, Donatella, BIAGETTI, Matteo, BERTANI, Barbara
Year of Publication 30.06.2022
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Year of Publication 30.06.2022
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