Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule
Tsai, Jordan C, Miller-Vedam, Lakshmi E, Anand, Aditya A, Jaishankar, Priyadarshini, Nguyen, Henry C, Renslo, Adam R, Frost, Adam, Walter, Peter
Published in Science (American Association for the Advancement of Science) (30.03.2018)
Published in Science (American Association for the Advancement of Science) (30.03.2018)
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A reactivity-based probe of the intracellular labile ferrous iron pool
Spangler, Benjamin, Morgan, Charles W, Fontaine, Shaun D, Vander Wal, Mark N, Chang, Christopher J, Wells, James A, Renslo, Adam R
Published in Nature chemical biology (01.09.2016)
Published in Nature chemical biology (01.09.2016)
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Protease inhibitors targeting coronavirus and filovirus entry
Zhou, Yanchen, Vedantham, Punitha, Lu, Kai, Agudelo, Juliet, Carrion, Ricardo, Nunneley, Jerritt W., Barnard, Dale, Pöhlmann, Stefan, McKerrow, James H., Renslo, Adam R., Simmons, Graham
Published in Antiviral research (01.04.2015)
Published in Antiviral research (01.04.2015)
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Pharmacological brake-release of mRNA translation enhances cognitive memory
Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter
Published in eLife (28.05.2013)
Published in eLife (28.05.2013)
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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
Sidrauski, Carmela, Tsai, Jordan C, Kampmann, Martin, Hearn, Brian R, Vedantham, Punitha, Jaishankar, Priyadarshini, Sokabe, Masaaki, Mendez, Aaron S, Newton, Billy W, Tang, Edward L, Verschueren, Erik, Johnson, Jeffrey R, Krogan, Nevan J, Fraser, Christopher S, Weissman, Jonathan S, Renslo, Adam R, Walter, Peter
Published in eLife (15.04.2015)
Published in eLife (15.04.2015)
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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter
Published in eLife (20.07.2016)
Published in eLife (20.07.2016)
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Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis
Chen, Ying-Chu, Oses-Prieto, Juan A, Pope, Lauren E, Burlingame, Alma L, Dixon, Scott J, Renslo, Adam R
Published in Journal of the American Chemical Society (11.11.2020)
Published in Journal of the American Chemical Society (11.11.2020)
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Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States
Gentile, Daniel R., Rathinaswamy, Manoj K., Jenkins, Meredith L., Moss, Steven M., Siempelkamp, Braden D., Renslo, Adam R., Burke, John E., Shokat, Kevan M.
Published in Cell chemical biology (21.12.2017)
Published in Cell chemical biology (21.12.2017)
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Cilia-Associated Oxysterols Activate Smoothened
Raleigh, David R., Sever, Navdar, Choksi, Pervinder K., Sigg, Monika Abedin, Hines, Kelly M., Thompson, Bonne M., Elnatan, Daniel, Jaishankar, Priyadarshini, Bisignano, Paola, Garcia-Gonzalo, Francesc R., Krup, Alexis Leigh, Eberl, Markus, Byrne, Eamon F.X., Siebold, Christian, Wong, Sunny Y., Renslo, Adam R., Grabe, Michael, McDonald, Jeffrey G., Xu, Libin, Beachy, Philip A., Reiter, Jeremy F.
Published in Molecular cell (18.10.2018)
Published in Molecular cell (18.10.2018)
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Drug resistance confounding prion therapeutics
Berry, David B, Lu, Duo, Geva, Michal, Watts, Joel C, Bhardwaj, Sumita, Oehler, Abby, Renslo, Adam R, DeArmond, Stephen J, Prusiner, Stanley B, Giles, Kurt
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2013)
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A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons
Kim, Gha-Hyun J, Mo, Han, Liu, Harrison, Wu, Zhihao, Chen, Steven, Zheng, Jiashun, Zhao, Xiang, Nucum, Daryl, Shortland, James, Peng, Longping, Elepano, Mannuel, Tang, Benjamin, Olson, Steven, Paras, Nick, Li, Hao, Renslo, Adam R, Arkin, Michelle R, Huang, Bo, Lu, Bingwei, Sirota, Marina, Guo, Su
Published in eLife (22.09.2021)
Published in eLife (22.09.2021)
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Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis
Admasu, Tesfahun Dessale, Kim, Kristie, Rae, Michael, Avelar, Roberto, Gonciarz, Ryan L., Rebbaa, Abdelhadi, Pedro de Magalhães, João, Renslo, Adam R., Stolzing, Alexandra, Sharma, Amit
Published in Cell reports (Cambridge) (28.02.2023)
Published in Cell reports (Cambridge) (28.02.2023)
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Predicting binding to p-glycoprotein by flexible receptor docking
Dolghih, Elena, Bryant, Clifford, Renslo, Adam R, Jacobson, Matthew P
Published in PLoS computational biology (01.06.2011)
Published in PLoS computational biology (01.06.2011)
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Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X‑ray Crystallography
Nichols, Derek A, Hargis, Jacqueline C, Sanishvili, Ruslan, Jaishankar, Priyadarshini, Defrees, Kyle, Smith, Emmanuel W, Wang, Kenneth K, Prati, Fabio, Renslo, Adam R, Woodcock, H. Lee, Chen, Yu
Published in Journal of the American Chemical Society (01.07.2015)
Published in Journal of the American Chemical Society (01.07.2015)
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2-Aminothiazoles as Therapeutic Leads for Prion Diseases
Gallardo-Godoy, Alejandra, Gever, Joel, Fife, Kimberly L, Silber, B. Michael, Prusiner, Stanley B, Renslo, Adam R
Published in Journal of medicinal chemistry (24.02.2011)
Published in Journal of medicinal chemistry (24.02.2011)
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Journal Article
A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models
Spangler, Benjamin, Fontaine, Shaun D, Shi, Yihui, Sambucetti, Lidia, Mattis, Aras N, Hann, Byron, Wells, James A, Renslo, Adam R
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening
Abdulla, Maha-Hamadien, Ruelas, Debbie S, Wolff, Brian, Snedecor, June, Lim, Kee-Chong, Xu, Fengyun, Renslo, Adam R, Williams, Janice, McKerrow, James H, Caffrey, Conor R
Published in PLoS neglected tropical diseases (14.07.2009)
Published in PLoS neglected tropical diseases (14.07.2009)
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High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations
Mott, Bryan T., Eastman, Richard T., Guha, Rajarshi, Sherlach, Katy S., Siriwardana, Amila, Shinn, Paul, McKnight, Crystal, Michael, Sam, Lacerda-Queiroz, Norinne, Patel, Paresma R., Khine, Pwint, Sun, Hongmao, Kasbekar, Monica, Aghdam, Nima, Fontaine, Shaun D., Liu, Dongbo, Mierzwa, Tim, Mathews-Griner, Lesley A., Ferrer, Marc, Renslo, Adam R., Inglese, James, Yuan, Jing, Roepe, Paul D., Su, Xin-zhuan, Thomas, Craig J.
Published in Scientific reports (25.09.2015)
Published in Scientific reports (25.09.2015)
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Discovery of 2-Aminothiazoles as Potent Antiprion Compounds
GHAEMMAGHAMI, Sina, MAY, Barnaby C. H, RENSLO, Adam R, PRUSINER, Stanley B
Published in Journal of Virology (01.04.2010)
Published in Journal of Virology (01.04.2010)
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