Natural-product-derived fragments for fragment-based ligand discovery
Over, Björn, Wetzel, Stefan, Grütter, Christian, Nakai, Yasushi, Renner, Steffen, Rauh, Daniel, Waldmann, Herbert
Published in Nature chemistry (01.01.2013)
Published in Nature chemistry (01.01.2013)
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Journal Article
DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery
Ye, Chaoyang, Ho, Daniel J., Neri, Marilisa, Yang, Chian, Kulkarni, Tripti, Randhawa, Ranjit, Henault, Martin, Mostacci, Nadezda, Farmer, Pierre, Renner, Steffen, Ihry, Robert, Mansur, Leandra, Keller, Caroline Gubser, McAllister, Gregory, Hild, Marc, Jenkins, Jeremy, Kaykas, Ajamete
Published in Nature communications (17.10.2018)
Published in Nature communications (17.10.2018)
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Journal Article
Small-molecule inhibition of APT1 affects Ras localization and signaling
Bastiaens, Philippe I H, Waldmann, Herbert, Dekker, Frank J, Rocks, Oliver, Vartak, Nachiket, Menninger, Sascha, Hedberg, Christian, Balamurugan, Rengarajan, Wetzel, Stefan, Renner, Steffen, Gerauer, Marc, Schölermann, Beate, Rusch, Marion, Kramer, John W, Rauh, Daniel, Coates, Geoffrey W, Brunsveld, Luc
Published in Nature Chemical Biology (01.06.2010)
Published in Nature Chemical Biology (01.06.2010)
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Journal Article
Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes
Renner, Steffen, Bergsdorf, Christian, Bouhelal, Rochdi, Koziczak-Holbro, Magdalena, Amati, Andrea Marco, Techer-Etienne, Valerie, Flotte, Ludivine, Reymann, Nicole, Kapur, Karen, Hoersch, Sebastian, Oakeley, Edward James, Schuffenhauer, Ansgar, Gubler, Hanspeter, Lounkine, Eugen, Farmer, Pierre
Published in Scientific reports (15.06.2020)
Published in Scientific reports (15.06.2020)
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Journal Article
Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design
Hedberg, Christian, Dekker, Frank J., Rusch, Marion, Renner, Steffen, Wetzel, Stefan, Vartak, Nachiket, Gerding-Reimers, Claas, Bon, Robin S., Bastiaens, Philippe I. H., Waldmann, Herbert
Published in Angewandte Chemie International Edition (10.10.2011)
Published in Angewandte Chemie International Edition (10.10.2011)
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Journal Article
Bioactivity-guided mapping and navigation of chemical space
Waldmann, Herbert, Renner, Steffen, van Otterlo, Willem A L, Dominguez Seoane, Marta, Möcklinghoff, Sabine, Hofmann, Bettina, Wetzel, Stefan, Schuffenhauer, Ansgar, Ertl, Peter, Oprea, Tudor I, Steinhilber, Dieter, Brunsveld, Luc, Rauh, Daniel
Published in Nature Chemical Biology (01.08.2009)
Published in Nature Chemical Biology (01.08.2009)
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Journal Article
Probing the Bioactivity-Relevant Chemical Space of Robust Reactions and Common Molecular Building Blocks
Hartenfeller, Markus, Eberle, Martin, Meier, Peter, Nieto-Oberhuber, Cristina, Altmann, Karl-Heinz, Schneider, Gisbert, Jacoby, Edgar, Renner, Steffen
Published in Journal of chemical information and modeling (25.05.2012)
Published in Journal of chemical information and modeling (25.05.2012)
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Journal Article
The scaffold tree: an efficient navigation in the scaffold universe
Ertl, Peter, Schuffenhauer, Ansgar, Renner, Steffen
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2011)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2011)
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Journal Article
Total Synthesis of Chondramide C and Its Binding Mode to F-Actin
Waldmann, Herbert, Hu, Tai-Shan, Renner, Steffen, Menninger, Sascha, Tannert, René, Oda, Toshiro, Arndt, Hans-Dieter
Published in Angewandte Chemie (International ed.) (11.08.2008)
Published in Angewandte Chemie (International ed.) (11.08.2008)
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Journal Article
Positive and Negative Modulation of Group I Metabotropic Glutamate Receptors
Vanejevs, Maksims, Jatzke, Claudia, Renner, Steffen, Müller, Sibylle, Hechenberger, Mirko, Bauer, Tanja, Klochkova, Anna, Pyatkin, Ilya, Kazyulkin, Denis, Aksenova, Elena, Shulepin, Sergey, Timonina, Olga, Haasis, Ariane, Gutcaits, Aleksandrs, Parsons, Christopher G, Kauss, Valerjans, Weil, Tanja
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Journal Article
New Allosteric Modulators of Metabotropic Glutamate Receptor 5 (mGluR5) Found by Ligand-Based Virtual Screening
Renner, Steffen, Noeske, Tobias, Parsons, Christopher G, Schneider, Petra, Weil, Tanja, Schneider, Gisbert
Published in Chembiochem : a European journal of chemical biology (01.04.2005)
Published in Chembiochem : a European journal of chemical biology (01.04.2005)
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Journal Article
A pseudo-ligand approach to virtual screening
Schüller, Andreas, Fechner, Uli, Renner, Steffen, Franke, Lutz, Weber, Lutz, Schneider, Gisbert
Published in Combinatorial chemistry & high throughput screening (01.06.2006)
Published in Combinatorial chemistry & high throughput screening (01.06.2006)
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Journal Article
Scaffold-Hopping: How Far Can You Jump?
Schneider, Gisbert, Schneider, Petra, Renner, Steffen
Published in QSAR & combinatorial science (01.12.2006)
Published in QSAR & combinatorial science (01.12.2006)
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Journal Article
Interactive exploration of chemical space with Scaffold Hunter
Waldmann, Herbert, Wetzel, Stefan, Klein, Karsten, Renner, Steffen, Rauh, Daniel, Oprea, Tudor I, Mutzel, Petra
Published in Nature Chemical Biology (01.08.2009)
Published in Nature Chemical Biology (01.08.2009)
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Journal Article
Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design
Hedberg, Christian, Dekker, Frank J., Rusch, Marion, Renner, Steffen, Wetzel, Stefan, Vartak, Nachiket, Gerding-Reimers, Claas, Bon, Robin S., Bastiaens, Philippe I. H., Waldmann, Herbert
Published in Angewandte Chemie (10.10.2011)
Published in Angewandte Chemie (10.10.2011)
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Journal Article
A Collection of Robust Organic Synthesis Reactions for In Silico Molecule Design
Hartenfeller, Markus, Eberle, Martin, Meier, Peter, Nieto-Oberhuber, Cristina, Altmann, Karl-Heinz, Schneider, Gisbert, Jacoby, Edgar, Renner, Steffen
Published in Journal of chemical information and modeling (27.12.2011)
Published in Journal of chemical information and modeling (27.12.2011)
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