Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase
Wales, Jessica A., Chen, Cheng-Yu, Breci, Linda, Weichsel, Andrzej, Bernier, Sylvie G., Sheppeck, James E., Solinga, Robert, Nakai, Takashi, Renhowe, Paul A., Jung, Joon, Montfort, William R.
Published in The Journal of biological chemistry (02.02.2018)
Published in The Journal of biological chemistry (02.02.2018)
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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3
Wagman, Allan S, Boyce, Rustum S, Brown, Sean P, Fang, Eric, Goff, Dane, Jansen, Johanna M, Le, Vincent P, Levine, Barry H, Ng, Simon C, Ni, Zhi-Jie, Nuss, John M, Pfister, Keith B, Ramurthy, Savithri, Renhowe, Paul A, Ring, David B, Shu, Wei, Subramanian, Sharadha, Zhou, Xiaohui A, Shafer, Cynthia M, Harrison, Stephen D, Johnson, Kirk W, Bussiere, Dirksen E
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Journal Article
The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases
Correia, Susana S., Iyengar, Rajesh R., Germano, Peter, Tang, Kim, Bernier, Sylvie G., Schwartzkopf, Chad D., Tobin, Jenny, Lee, Thomas W.-H., Liu, Guang, Jacobson, Sarah, Carvalho, Andrew, Rennie, Glen R., Jung, Joon, Renhowe, Paul A., Lonie, Elisabeth, Winrow, Christopher J., Hadcock, John R., Jones, Juli E., Currie, Mark G.
Published in Frontiers in pharmacology (24.05.2021)
Published in Frontiers in pharmacology (24.05.2021)
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Journal Article
Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator
Rennie, Glen R., Barden, Timothy C., Bernier, Sylvie G., Carvalho, Andrew, Deming, Renee, Germano, Peter, Hudson, Colleen, Im, G-Yoon J., Iyengar, Rajesh R., Jia, Lei, Jung, Joon, Kim, Elise, Lee, Thomas W.-H., Mermerian, Ara, Moore, Joel, Nakai, Takashi, Perl, Nicholas R., Tobin, Jenny, Zimmer, Daniel P., Renhowe, Paul A.
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
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Journal Article
Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors
Renhowe, Paul A, Pecchi, Sabina, Shafer, Cynthia M, Machajewski, Timothy D, Jazan, Elisa M, Taylor, Clarke, Antonios-McCrea, William, McBride, Christopher M, Frazier, Kelly, Wiesmann, Marion, Lapointe, Gena R, Feucht, Paul H, Warne, Robert L, Heise, Carla C, Menezes, Daniel, Aardalen, Kimberly, Ye, Helen, He, Molly, Le, Vincent, Vora, Jayesh, Jansen, Johanna M, Wernette-Hammond, Mary Ellen, Harris, Alex L
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Journal Article
Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma
Williams, Teresa E, Subramanian, Sharadha, Verhagen, Joelle, McBride, Christopher M, Costales, Abran, Sung, Leonard, Antonios-McCrea, William, McKenna, Maureen, Louie, Alicia K, Ramurthy, Savithri, Levine, Barry, Shafer, Cynthia M, Machajewski, Timothy, Renhowe, Paul A, Appleton, Brent A, Amiri, Payman, Chou, James, Stuart, Darrin, Aardalen, Kimberly, Poon, Daniel
Published in ACS medicinal chemistry letters (10.09.2015)
Published in ACS medicinal chemistry letters (10.09.2015)
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Journal Article
Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors
Ramurthy, Savithri, Subramanian, Sharadha, Aikawa, Mina, Amiri, Payman, Costales, Abran, Dove, Jeff, Fong, Susan, Jansen, Johanna M, Levine, Barry, Ma, Sylvia, McBride, Christopher M, Michaelian, Jonah, Pick, Teresa, Poon, Daniel J, Girish, Sandhya, Shafer, Cynthia M, Stuart, Darrin, Sung, Leonard, Renhowe, Paul A
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
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Journal Article
Design and synthesis of 6,6-fused heterocyclic amides as raf kinase inhibitors
Ramurthy, Savithri, Costales, Abran, Jansen, Johanna M., Levine, Barry, Renhowe, Paul A., Shafer, Cynthia M., Subramanian, Sharadha
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors
Ramurthy, Savithri, Aikawa, Mina, Amiri, Payman, Costales, Abran, Hashash, Ahmad, Jansen, Johanna M., Lin, Song, Ma, Sylvia, Renhowe, Paul A., Shafer, Cynthia M., Subramanian, Sharadha, Sung, Leonard, Verhagen, Joelle
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Journal Article
Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors
Subramanian, Sharadha, Costales, Abran, Williams, Teresa E, Levine, Barry, McBride, Christopher M, Poon, Daniel, Amiri, Payman, Renhowe, Paul A, Shafer, Cynthia M, Stuart, Darrin, Verhagen, Joelle, Ramurthy, Savithri
Published in ACS medicinal chemistry letters (11.09.2014)
Published in ACS medicinal chemistry letters (11.09.2014)
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Journal Article
Identification and structure–activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors
Pecchi, Sabina, Renhowe, Paul A., Taylor, Clarke, Kaufman, Susan, Merritt, Hanne, Wiesmann, Marion, Shoemaker, Kevin R., Knapp, Mark S., Ornelas, Elizabeth, Hendrickson, Thomas F., Fantl, Wendy, Voliva, Charles F.
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Journal Article
4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors
Ni, Zhi-Jie, Barsanti, Paul, Brammeier, Nathan, Diebes, Anthony, Poon, Daniel J., Ng, Simon, Pecchi, Sabina, Pfister, Keith, Renhowe, Paul A., Ramurthy, Savithri, Wagman, Allan S., Bussiere, Dirksen E., Le, Vincent, Zhou, Yasheen, Jansen, Johanna M., Ma, Sylvia, Gesner, Thomas G.
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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Journal Article
Enantioselective Total Synthesis of (-)-Ptilomycalin A
Overman, Larry E, Rabinowitz, Michael H, Renhowe, Paul A
Published in Journal of the American Chemical Society (01.03.1995)
Published in Journal of the American Chemical Society (01.03.1995)
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Journal Article
Design and structure–activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases
McBride, Christopher M., Renhowe, Paul A., Heise, Carla, Jansen, Johanna M., Lapointe, Gena, Ma, Sylvia, Piñeda, Ramon, Vora, Jayesh, Wiesmann, Marion, Shafer, Cynthia M.
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
Correction to Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors
Subramanian, Sharadha, Costales, Abran, Williams, Teresa E, Levine, Barry, McBride, Christopher M, Poon, Daniel, Amiri, Payman, Renhowe, Paul A, Shafer, Cynthia M, Stuart, Darrin, Verhagen, Joelle, Ramurthy, Savithri
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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Journal Article
A Practical Entry to the Crambescidin Family of Guanidine Alkaloids. Enantioselective Total Syntheses of Ptilomycalin A, Crambescidin 657 and Its Methyl Ester (Neofolitispates 2), and Crambescidin 800
Coffey, D. Scott, McDonald, Andrew I, Overman, Larry E, Rabinowitz, Michael H, Renhowe, Paul A
Published in Journal of the American Chemical Society (24.05.2000)
Published in Journal of the American Chemical Society (24.05.2000)
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Journal Article
3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors
MCBRIDE, Christopher M, RENHOWE, Paul A, GESNER, Thomas G, JANSEN, Johanna M, JULIE LIN, MA, Sylvia, ZHOU, Yasheen, SHAFER, Cynthia M
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Journal Article
Investigations of a Nucleophilic Alaninol Synthon Derived from Serine
Sibi, Mukund P, Rutherford, Drew, Renhowe, Paul A, Li, Biqin
Published in Journal of the American Chemical Society (25.08.1999)
Published in Journal of the American Chemical Society (25.08.1999)
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