Development of the Synthetic Route to PF-06878031 Part 1: Selective Alkylation Route
Brea, Oriana, Buck, Julia, Carson, Nessa, Derrick, Andrew M., Fussell, Steven J., Gymer, Adam E. S., Hawksworth, Michael, Hopkins, Adam W., Ingram, Heather, Johnson, Rebecca A., Laity, Daniel A., Mathew, Jinu S., Moses, Ian B., Rellegue, James, Rose, Emily K., Twiddle, Steven J. R., West, Adam
Published in Organic process research & development (19.07.2024)
Published in Organic process research & development (19.07.2024)
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Journal Article
Development of the Synthetic Route to PF-06878031 Part 2: Amide Reduction Route
Brown, Maria S., Buck, Julia, Critcher, Douglas J., Derrick, Andrew M., Fenton, Harriet, Fussell, Steven J., Gymer, Adam E. S., Hawksworth, Michael, Ingram, Heather, Johnson, Rebecca A., Kumar, Rajesh, Laity, Daniel A., Lewis, Russell D., Mathew, Jinu S., McGivern, Laura, Moses, Ian B., Palaia, Andrew T., Patel, Miheal J., Rellegue, James, Rose, Emily K., Scott, Adam, Steflik, Jeremy, Twiddle, Steven J. R.
Published in Organic process research & development (19.07.2024)
Published in Organic process research & development (19.07.2024)
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Journal Article
METHODS AND INTERMEDIATES FOR PREPARING 2-[(4-{6-[(4-CYANO-2-FLUOROBENZYL)OXY]PYRIDIN-2-YL}PIPERIDIN-1-YL)METHYL]-1-[(2S)-OXETAN-2-YLMETHYL]-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID, 1,3-DIHYDROXY-2-(HYDROXYMETHYL)PROPAN-2-AMINE SALT
CARSON, Laura Jane Elizabeth, CLARKE, James, MCGIVERN, Laura Caroline, MATHEW, Jinu Suju, FUSSELL, Steven James, GYMER, Adam Edward Sanji, DION, Amelie, MILLS, James Alan, MOSES, Ian Brian, LAITY, Daniel Andrew, PIBWORTH, Benjamin Alan, RELLEGUE, James, ROSE, Emily Kay, BADLAND, Matthew, WHITE, Chloe Joy, SVOBODA, Vaclav, WEST, Adam Sebastian, REYNOLDS- SCOTT, Adam John
Year of Publication 25.01.2024
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Year of Publication 25.01.2024
Patent
Methods and intermediates for preparing 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2S)-oxetan-2-ylmethyl]-1H-benzimidazole-6-carboxylic acid, 1,3-dihydroxy-2-(hydroxymethyl)propan-2-amine salt
GYMER, ADAM EDWARD SANJI, BADLAND, MATTHEW, MATHEW, JINU SUJU, MCGIVERN, LAURA CAROLINE, DION, AMELIE, LAITY, DANIEL ANDREW, WHITE, CHLOE JOY, MOSES, IAN BRIAN, WEST, ADAM SEBASTIAN, RELLEGUE, JAMES, REYNOLDS-SCOTT, ADAM JOHN, FUSSELL, STEVEN JAMES, ROSE, EMILY KAY, CARSON, LAURA JANE ELIZABETH, CLARKE, JAMES, SVOBODA, VACLAV, MILLS, JAMES ALAN, PIBWORTH, BENJAMIN ALAN
Year of Publication 01.04.2024
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Year of Publication 01.04.2024
Patent