ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope
Phillips, Andrew C, Boghaert, Erwin R, Vaidya, Kedar S, Mitten, Michael J, Norvell, Suzanne, Falls, Hugh D, DeVries, Peter J, Cheng, Dong, Meulbroek, Jonathan A, Buchanan, Fritz G, McKay, Laura M, Goodwin, Neal C, Reilly, Edward B
Published in Molecular cancer therapeutics (01.04.2016)
Published in Molecular cancer therapeutics (01.04.2016)
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First-in-Human Phase I, Dose-Escalation and -Expansion Study of Telisotuzumab Vedotin, an Antibody-Drug Conjugate Targeting c-Met, in Patients With Advanced Solid Tumors
Strickler, John H, Weekes, Colin D, Nemunaitis, John, Ramanathan, Ramesh K, Heist, Rebecca S, Morgensztern, Daniel, Angevin, Eric, Bauer, Todd M, Yue, Huibin, Motwani, Monica, Parikh, Apurvasena, Reilly, Edward B, Afar, Daniel, Naumovski, Louie, Kelly, Karen
Published in Journal of clinical oncology (20.11.2018)
Published in Journal of clinical oncology (20.11.2018)
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ABBV-399, a c-Met Antibody-Drug Conjugate that Targets Both MET -Amplified and c-Met-Overexpressing Tumors, Irrespective of MET Pathway Dependence
Wang, Jieyi, Anderson, Mark G, Oleksijew, Anatol, Vaidya, Kedar S, Boghaert, Erwin R, Tucker, Lora, Zhang, Qian, Han, Edward K, Palma, Joann P, Naumovski, Louie, Reilly, Edward B
Published in Clinical cancer research (15.02.2017)
Published in Clinical cancer research (15.02.2017)
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Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody–Drug Conjugate
Anderson, Mark G., Falls, Hugh D., Mitten, Michael J., Oleksijew, Anatol, Vaidya, Kedar S., Boghaert, Erwin R., Gao, Wenqing, Palma, Joann P., Cao, Diana, Chia, Puey-Ling, John, Thomas, Gan, Hui K., Scott, Andrew M., Reilly, Edward B.
Published in Molecular cancer therapeutics (01.10.2020)
Published in Molecular cancer therapeutics (01.10.2020)
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ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition
Anderson, Mark G, Zhang, Qian, Rodriguez, Luis E, Hecquet, Claudie M, Donawho, Cherrie K, Ansell, Peter J, Reilly, Edward B
Published in BMC cancer (09.06.2021)
Published in BMC cancer (09.06.2021)
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Biodistribution Analysis of an Anti-EGFR Antibody in the Rat Brain: Validation of CSF Microcirculation as a Viable Pathway to Circumvent the Blood-Brain Barrier for Drug Delivery
Naseri Kouzehgarani, Ghazal, Kumar, Pankaj, Bolin, Susan E., Reilly, Edward B., Lefebvre, Didier R.
Published in Pharmaceutics (12.07.2022)
Published in Pharmaceutics (12.07.2022)
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Bystander Effects, Pharmacokinetics, and Linker-Payload Stability of EGFR-Targeting Antibody-Drug Conjugates Losatuxizumab Vedotin and Depatux-M in Glioblastoma Models
Jain, Sonia, Griffith, Jessica I, Porath, Kendra A, Rathi, Sneha, Le, Jiayan, Pasa, Tugce I, Decker, Paul A, Gupta, Shiv K, Hu, Zeng, Carlson, Brett L, Bakken, Katrina, Burgenske, Danielle M, Feldsien, Thomas M, Lefebvre, Didier R, Vaubel, Rachael A, Eckel-Passow, Jeanette E, Reilly, Edward B, Elmquist, William F, Sarkaria, Jann N
Published in Clinical cancer research (01.08.2024)
Published in Clinical cancer research (01.08.2024)
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A Phase 1 and Biodistribution Study of ABT-806i, an 111In-Radiolabeled Conjugate of the Tumor-Specific Anti-EGFR Antibody ABT-806
Gan, Hui K, Burge, Matthew, Solomon, Benjamin, Lee, Sze Ting, Holen, Kyle D, Zhang, Yumin, Ciprotti, Marika, Lee, FT, Munasinghe, Wijith, Fischer, JuDee, Ansell, Peter, Fox, Gerard, Xiong, Hao, Reilly, Edward B, Humerickhouse, Rod, Scott, Andrew M
Published in The Journal of nuclear medicine (1978) (01.06.2021)
Published in The Journal of nuclear medicine (1978) (01.06.2021)
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ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies
Chervin, Adam S, Stone, Jennifer D, Konieczna, Iwona, Calabrese, Kelly M, Wang, Ningyan, Haribhai, Dipica, Dong, Feng, White, Michael K, Rodriguez, Luis E, Bukofzer, Gail T, Ellis, Paul A, Cosgrove, Cormac, Hecquet, Claudie, Clarin, Jerry D, Palma, Joann P, Reilly, Edward B
Published in Molecular cancer therapeutics (01.08.2023)
Published in Molecular cancer therapeutics (01.08.2023)
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Characterization of ABBV-221, a Tumor-Selective EGFR-Targeting Antibody Drug Conjugate
Phillips, Andrew C, Boghaert, Erwin R, Vaidya, Kedar S, Falls, Hugh D, Mitten, Michael J, DeVries, Peter J, Benatuil, Lorenzo, Hsieh, Chung-Ming, Meulbroek, Jonathan A, Panchal, Sanjay C, Buchanan, Fritz G, Durbin, Kenneth R, Voorbach, Martin J, Reuter, David R, Mudd, Sarah R, Loberg, Lise I, Ralston, Sherry L, Cao, Diana, Gan, Hui K, Scott, Andrew M, Reilly, Edward B
Published in Molecular cancer therapeutics (01.04.2018)
Published in Molecular cancer therapeutics (01.04.2018)
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Efficacy and safety results of depatuxizumab mafodotin (ABT‐414) in patients with advanced solid tumors likely to overexpress epidermal growth factor receptor
Goss, Glenwood D., Vokes, Everett E., Gordon, Michael S., Gandhi, Leena, Papadopoulos, Kyriakos P., Rasco, Drew W., Fischer, JuDee S., Chu, Katharine L., Ames, William W., Mittapalli, Rajendar K., Lee, Ho‐Jin, Zeng, Jiewei, Roberts‐Rapp, Lisa A., Loberg, Lise I., Ansell, Peter J., Reilly, Edward B., Ocampo, Christopher J., Holen, Kyle D., Tolcher, Anthony W.
Published in Cancer (15.05.2018)
Published in Cancer (15.05.2018)
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Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody
Reilly, Edward B, Phillips, Andrew C, Buchanan, Fritz G, Kingsbury, Gillian, Zhang, Yumin, Meulbroek, Jonathan A, Cole, Todd B, DeVries, Peter J, Falls, Hugh D, Beam, Christine, Gu, Jinming, Digiammarino, Enrico L, Palma, Joann P, Donawho, Cherrie K, Goodwin, Neal C, Scott, Andrew M
Published in Molecular cancer therapeutics (01.05.2015)
Published in Molecular cancer therapeutics (01.05.2015)
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COVID‐19: A Catalyst to Accelerate Global Regulatory Transformation
Stewart, Jerry, Honig, Peter, AlJuburi, Lina, Autor, Deborah, Berger, Susan, Brady, Patrick, Fitton, Helen, Garner, Carlos, Garvin, Michael, Hukkelhoven, Mathias, Kowalski, Robert, Milligan, Sandra, Liza O’Dowd, Reilly, Edward, Roberts, Khyati, Robertson, Andrew S, Taisey, Mark, Thakkar, Roopal, Karin Van Baelen, Wegner, Max
Published in Clinical Pharmacology & Therapeutics (01.06.2021)
Published in Clinical Pharmacology & Therapeutics (01.06.2021)
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Synergistic therapeutic benefit by combining the antibody drug conjugate, depatux-m with temozolomide in pre-clinical models of glioblastoma with overexpression of EGFR
Vaidya, Kedar S., Mitten, Michael J., Zelaya-Lazo, Adelyn L., Oleksijew, Anatol, Alvey, Cory, Falls, Hugh D., Mishra, Sasmita, Palma, Joann, Ansell, Peter, Phillips, Andrew C., Reilly, Edward B., Anderson, Mark, Boghaert, Erwin R.
Published in Journal of neuro-oncology (01.04.2021)
Published in Journal of neuro-oncology (01.04.2021)
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Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification
Wang, Jieyi, Goetsch, Liliane, Tucker, Lora, Zhang, Qian, Gonzalez, Alexandra, Vaidya, Kedar S, Oleksijew, Anatol, Boghaert, Erwin, Song, Minghao, Sokolova, Irina, Pestova, Ekaterina, Anderson, Mark, Pappano, William N, Ansell, Peter, Bhathena, Anahita, Naumovski, Louie, Corvaia, Nathalie, Reilly, Edward B
Published in BMC cancer (16.02.2016)
Published in BMC cancer (16.02.2016)
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Cytotoxicity of the CD3×CD20 bispecific antibody epcoritamab in CLL is increased by concurrent BTK or BCL-2 targeting
Mhibik, Maissa, Gaglione, Erika M., Eik, David, Herrick, John, Le, Janet, Ahn, Inhye E., Chiu, Christopher, Wielgos-Bonvallet, Monica, Hiemstra, Ida H., Breij, Esther C. W., Chen, Jenny, Reilly, Edward B., Epling-Burnette, Pearlie K., Szafer-Glusman, Edith, Sun, Clare, Wiestner, Adrian
Published in Blood advances (08.08.2023)
Published in Blood advances (08.08.2023)
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Targeting and Efficacy of Novel mAb806-Antibody-Drug Conjugates in Malignant Mesothelioma
Chia, Puey-Ling, Parakh, Sagun, Tsao, Ming-Sound, Pham, Nhu-An, Gan, Hui K, Cao, Diana, Burvenich, Ingrid J G, Rigopoulos, Angela, Reilly, Edward B, John, Thomas, Scott, Andrew M
Published in Pharmaceuticals (Basel, Switzerland) (02.10.2020)
Published in Pharmaceuticals (Basel, Switzerland) (02.10.2020)
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A phase 1 study of ABT-806 in subjects with advanced solid tumors
Cleary, James M., Reardon, David A., Azad, Nilofer, Gandhi, Leena, Shapiro, Geoffrey I., Chaves, Jorge, Pedersen, Michelle, Ansell, Peter, Ames, William, Xiong, Hao, Munasinghe, Wijith, Dudley, Matt, Reilly, Edward B., Holen, Kyle, Humerickhouse, Rod
Published in Investigational new drugs (01.06.2015)
Published in Investigational new drugs (01.06.2015)
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A vision for integrated publicly available information on regulated medical products
Roberts, Khyati, Thakkar, Roopal, Aljuburi, Lina, Boyce, Donna, Curtis, Sean, Dudinak, Jennifer, Fitton, Helen, Garner, Carlos, Garvin, Michael, Longman, Susan, Reilly, Edward, Maitland, Jordan, Reisin Miller, Alexis, Pasté, Muriel, Rohrer, Michelle, Taisey, Mark, Van Baelen, Karin, Wegner, Max
Published in Clinical and translational science (01.06.2022)
Published in Clinical and translational science (01.06.2022)
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Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties
Liu, Gang, Huth, Jeffrey R, Olejniczak, Edward T, Mendoza, Renaldo, DeVries, Peter, Leitza, Sandra, Reilly, Edward B, Okasinski, Gregory F, Fesik, Stephen W, von Geldern, Thomas W
Published in Journal of medicinal chemistry (12.04.2001)
Published in Journal of medicinal chemistry (12.04.2001)
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