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Published in Science translational medicine (30.11.2016)
Published in Science translational medicine (30.11.2016)
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Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition
Weigert, Oliver, Lane, Andrew A, Bird, Liat, Kopp, Nadja, Chapuy, Bjoern, van Bodegom, Diederik, Toms, Angela V, Marubayashi, Sachie, Christie, Amanda L, McKeown, Michael, Paranal, Ronald M, Bradner, James E, Yoda, Akinori, Gaul, Christoph, Vangrevelinghe, Eric, Romanet, Vincent, Murakami, Masato, Tiedt, Ralph, Ebel, Nicolas, Evrot, Emeline, De Pover, Alain, Régnier, Catherine H, Erdmann, Dirk, Hofmann, Francesco, Eck, Michael J, Sallan, Stephen E, Levine, Ross L, Kung, Andrew L, Baffert, Fabienne, Radimerski, Thomas, Weinstock, David M
Published in The Journal of experimental medicine (13.02.2012)
Published in The Journal of experimental medicine (13.02.2012)
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Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality
Shi, Tiffany, Burg, Ashley R, Caldwell, J Timothy, Roskin, Krishna M, Castro-Rojas, Cyd M, Chukwuma, P Chukwunalu, Gray, George I, Foote, Sara G, Alonso, Jesus A, Cuda, Carla M, Allman, David A, Rush, James S, Regnier, Catherine H, Wieczorek, Grazyna, Alloway, Rita R, Shields, Adele R, Baker, Brian M, Woodle, E Steve, Hildeman, David A
Published in The Journal of clinical investigation (01.07.2023)
Published in The Journal of clinical investigation (01.07.2023)
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Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent
Andraos, Rita, Qian, Zhiyan, Bonenfant, Débora, Rubert, Joëlle, Vangrevelinghe, Eric, Scheufler, Clemens, Marque, Fanny, Régnier, Catherine H, De Pover, Alain, Ryckelynck, Hugues, Bhagwat, Neha, Koppikar, Priya, Goel, Aviva, Wyder, Lorenza, Tavares, Gisele, Baffert, Fabienne, Pissot-Soldermann, Carole, Manley, Paul W, Gaul, Christoph, Voshol, Hans, Levine, Ross L, Sellers, William R, Hofmann, Francesco, Radimerski, Thomas
Published in Cancer discovery (01.06.2012)
Published in Cancer discovery (01.06.2012)
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The prevalence, disease characteristics and treatment of chronic venous disease: an international web-based survey
Rabe, Eberhard, Régnier, Catherine, Goron, Fabienne, Salmat, Ghislaine, Pannier, Felizitas
Published in Journal of comparative effectiveness research (01.12.2020)
Published in Journal of comparative effectiveness research (01.12.2020)
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Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome
Bienaime, Frank, Dragon-Durey, Marie-Agnes, Regnier, Catherine H., Nilsson, Sara C., Kwan, Wing H., Blouin, Jacques, Jablonski, Mathieu, Renault, Nicolas, Rameix-Welti, Marie-Anne, Loirat, Chantal, Sautés-Fridman, Catherine, Villoutreix, Bruno O., Blom, Anna M., Fremeaux-Bacchi, Veronique
Published in Kidney international (01.02.2010)
Published in Kidney international (01.02.2010)
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Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
Roumenina, Lubka T., Jablonski, Mathieu, Hue, Christophe, Blouin, Jacques, Dimitrov, Jordan D., Dragon-Durey, Marie-Agnes, Cayla, Mathieu, Fridman, Wolf H., Macher, Marie-Alice, Ribes, David, Moulonguet, Luc, Rostaing, Lionel, Satchell, Simon C., Mathieson, Peter W., Sautes-Fridman, Catherine, Loirat, Chantal, Regnier, Catherine H., Halbwachs-Mecarelli, Lise, Fremeaux-Bacchi, Veronique
Published in Blood (24.09.2009)
Published in Blood (24.09.2009)
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Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors
Pissot-Soldermann, Carole, Gerspacher, Marc, Furet, Pascal, Gaul, Christoph, Holzer, Philipp, McCarthy, Clive, Radimerski, Thomas, Regnier, Catherine H., Baffert, Fabienne, Drueckes, Peter, Tavares, Gisele A., Vangrevelinghe, Eric, Blasco, Francesca, Ottaviani, Giorgio, Ossola, Flavio, Scesa, Julien, Reetz, Janitha
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation
Bornancin, Frédéric, Renner, Florian, Touil, Ratiba, Sic, Heiko, Kolb, Yeter, Touil-Allaoui, Ismahane, Rush, James S, Smith, Paul A, Bigaud, Marc, Junker-Walker, Ursula, Burkhart, Christoph, Dawson, Janet, Niwa, Satoru, Katopodis, Andreas, Nuesslein-Hildesheim, Barbara, Weckbecker, Gisbert, Zenke, Gerhard, Kinzel, Bernd, Traggiai, Elisabetta, Brenner, Dirk, Brüstle, Anne, St Paul, Michael, Zamurovic, Natasa, McCoy, Kathy D, Rolink, Antonius, Régnier, Catherine H, Mak, Tak W, Ohashi, Pamela S, Patel, Dhavalkumar D, Calzascia, Thomas
Published in The Journal of immunology (1950) (15.04.2015)
Published in The Journal of immunology (1950) (15.04.2015)
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Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood
Quancard, Jean, Simic, Oliver, Pissot Soldermann, Carole, Aichholz, Reiner, Blatter, Markus, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Endres, Ralf, Sorge, Mickael, Kieffer, Laurence, Wagner, Trixie, Beltz, Karen, Mcsheehy, Paul, Wartmann, Markus, Régnier, Catherine H, Calzascia, Thomas, Radimerski, Thomas, Bigaud, Marc, Weiss, Andreas, Bornancin, Frédéric, Schlapbach, Achim
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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The identification and characterization of a STAT5 gene signature in hematologic malignancies
Sonkin, Dmitriy, Palmer, Michael, Rong, Xianhui, Horrigan, Kim, Regnier, Catherine H, Fanton, Christie, Holash, Jocelyn, Pinzon-Ortiz, Maria, Squires, Matthew, Sirulnik, Andres, Radimerski, Thomas, Schlegel, Robert, Morrissey, Michael, Cao, Z Alexander
Published in Cancer biomarkers : section A of Disease markers (2015)
Published in Cancer biomarkers : section A of Disease markers (2015)
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Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing
Pissot Soldermann, Carole, Simic, Oliver, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Wartmann, Markus, Bigaud, Marc, Weiss, Andreas, McSheehy, Paul, Endres, Ralf, Santos, Paulo, Blank, Jutta, Schuffenhauer, Ansgar, Bold, Guido, Buschmann, Nicole, Zoller, Thomas, Altmann, Eva, Manley, Paul W, Dix, Ina, Buchdunger, Elisabeth, Scesa, Julien, Quancard, Jean, Schlapbach, Achim, Bornancin, Frédéric, Radimerski, Thomas, Régnier, Catherine H
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling
Klein, Theo, Fung, Shan-Yu, Renner, Florian, Blank, Michael A, Dufour, Antoine, Kang, Sohyeong, Bolger-Munro, Madison, Scurll, Joshua M, Priatel, John J, Schweigler, Patrick, Melkko, Samu, Gold, Michael R, Viner, Rosa I, Régnier, Catherine H, Turvey, Stuart E, Overall, Christopher M
Published in Nature communications (03.11.2015)
Published in Nature communications (03.11.2015)
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2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors
Gerspacher, Marc, Furet, Pascal, Pissot-Soldermann, Carole, Gaul, Christoph, Holzer, Philipp, Vangrevelinghe, Eric, Lang, Marc, Erdmann, Dirk, Radimerski, Thomas, Regnier, Catherine H., Chene, Patrick, Pover, Alain De, Hofmann, Francesco, Baffert, Fabienne, Buhl, Thomas, Aichholz, Reiner, Blasco, Francesca, Endres, Ralf, Trappe, Jörg, Drueckes, Peter
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition
Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric
Published in Immunology and cell biology (01.01.2018)
Published in Immunology and cell biology (01.01.2018)
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Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation
Ginster, Stefanie, Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Renner, Florian, Lam, Stephen, Freuler, Felix, Gerrits, Bertran, Voshol, Johannes, Calzascia, Thomas, Régnier, Catherine H, Renatus, Martin, Nikolay, Rainer, Israël, Laura, Bornancin, Frédéric
Published in PloS one (04.01.2017)
Published in PloS one (04.01.2017)
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N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity
Schlapbach, Achim, Revesz, Laszlo, Pissot Soldermann, Carole, Zoller, Thomas, Régnier, Catherine H., Bornancin, Frédéric, Radimerski, Thomas, Blank, Jutta, Schuffenhauer, Ansgar, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Heng, Richard, Simic, Oliver, Endres, Ralf, Wartmann, Markus, Quancard, Jean
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
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Requirement of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor–Induced Arthritis, but Not Fcγ Receptor–Mediated Platelet Elimination, in Mice
Martin, Kea, Touil, Ratiba, Cvijetic, Grozdan, Israel, Laura, Kolb, Yeter, Sarret, Sophie, Valeaux, Stéphanie, Degl'Innocenti, Elena, Le Meur, Thomas, Caesar, Nadja, Bardet, Maureen, Beerli, Christian, Zerwes, Hans‐Guenter, Kovarik, Jiri, Beltz, Karen, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H., Bigaud, Marc, Junt, Tobias, Wieczorek, Grazyna, Isnardi, Isabelle, Littlewood‐Evans, Amanda, Bornancin, Frédéric, Calzascia, Thomas
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2020)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2020)
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Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805
Baffert, Fabienne, Régnier, Catherine H, De Pover, Alain, Pissot-Soldermann, Carole, Tavares, Gisele A, Blasco, Francesca, Brueggen, Josef, Chène, Patrick, Drueckes, Peter, Erdmann, Dirk, Furet, Pascal, Gerspacher, Marc, Lang, Marc, Ledieu, David, Nolan, Lynda, Ruetz, Stephan, Trappe, Joerg, Vangrevelinghe, Eric, Wartmann, Markus, Wyder, Lorenza, Hofmann, Francesco, Radimerski, Thomas
Published in Molecular cancer therapeutics (01.07.2010)
Published in Molecular cancer therapeutics (01.07.2010)
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