Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia
Roecker, Anthony J., Reger, Thomas S., Mattern, M. Christa, Mercer, Swati P., Bergman, Jeffrey M., Schreier, John D., Cube, Rowena V., Cox, Christopher D., Li, Dansu, Lemaire, Wei, Bruno, Joseph G., Harrell, C. Meacham, Garson, Susan L., Gotter, Anthony L., Fox, Steven V., Stevens, Joanne, Tannenbaum, Pamela L., Prueksaritanont, Thomayant, Cabalu, Tamara D., Cui, Donghui, Stellabott, Joyce, Hartman, George D., Young, Steven D., Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.10.2014)
Published in Bioorganic & medicinal chemistry letters (15.10.2014)
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Journal Article
In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice
Kraus, Richard L, Li, Yuxing, Gregan, Yun, Gotter, Anthony L, Uebele, Victor N, Fox, Steven V, Doran, Scott M, Barrow, James C, Yang, Zhi-Qiang, Reger, Thomas S, Koblan, Kenneth S, Renger, John J
Published in The Journal of pharmacology and experimental therapeutics (01.11.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2010)
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Journal Article
Science of Sealing: Advanced Materials for High-Temperature Applications
Reger, Thomas S., Reichl, Gary J.
Published in 2020 31st Annual SEMI Advanced Semiconductor Manufacturing Conference (ASMC) (01.08.2020)
Published in 2020 31st Annual SEMI Advanced Semiconductor Manufacturing Conference (ASMC) (01.08.2020)
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Conference Proceeding
Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice
Uebele, Victor N, Gotter, Anthony L, Nuss, Cindy E, Kraus, Richard L, Doran, Scott M, Garson, Susan L, Reiss, Duane R, Li, Yuxing, Barrow, James C, Reger, Thomas S, Yang, Zhi-Qiang, Ballard, Jeanine E, Tang, Cuyue, Metzger, Joseph M, Wang, Sheng-Ping, Koblan, Kenneth S, Renger, John J
Published in The Journal of clinical investigation (01.06.2009)
Published in The Journal of clinical investigation (01.06.2009)
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Journal Article
Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists
Schlegel, Kelly-Ann S., Yang, Zhi-Qiang, Reger, Thomas S., Shu, Youheng, Cube, Rowena, Rittle, Kenneth E., Bondiskey, Phung, Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Kraus, Richard L., Li, Yuxing, Uebele, Victor N., Renger, John J., Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Pyridyl amides as potent inhibitors of T-type calcium channels
Reger, Thomas S., Yang, Zhi-Qiang, Schlegel, Kelly-Ann S., Shu, Youheng, Mattern, Christa, Cube, Rowena, Rittle, Kenneth E., McGaughey, Georgia B., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Li, Yuxing, Kraus, Richard L., Uebele, Victor N., Renger, John J., Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists
Uebele, Victor N, Nuss, Cindy E, Fox, Steven V, Garson, Susan L, Cristescu, Razvan, Doran, Scott M, Kraus, Richard L, Santarelli, Vincent P, Li, Yuxing, Barrow, James C, Yang, Zhi-Qiang, Schlegel, Kelly-Ann S, Rittle, Kenneth E, Reger, Thomas S, Bednar, Rodney A, Lemaire, Wei, Mullen, Faith A, Ballard, Jeanine E, Tang, Cuyue, Dai, Ge, McManus, Owen B, Koblan, Kenneth S, Renger, John J
Published in Cell biochemistry and biophysics (01.11.2009)
Published in Cell biochemistry and biophysics (01.11.2009)
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Journal Article
Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists
Barrow, James C, Rittle, Kenneth E, Reger, Thomas S, Yang, Zhi-Qiang, Bondiskey, Phung, McGaughey, Georgia B, Bock, Mark G, Hartman, George D, Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E, Doran, Scott M, Fox, Steven V, Garson, Susan L, Kraus, Richard L, Li, Yuxing, Marino, Michael J, Kuzmick Graufelds, Valerie, Uebele, Victor N, Renger, John J
Published in ACS medicinal chemistry letters (13.05.2010)
Published in ACS medicinal chemistry letters (13.05.2010)
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Journal Article
Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists
Reger, Thomas S., Zunic, Jasmine, Stock, Nicholas, Wang, Bowei, Smith, Nicholas D., Munoz, Benito, Green, Mitchell D., Gardner, Michael F., James, Joyce P., Chen, Weichao, Alves, Kenneth, Si, Qian, Treonze, Kelly M., Lingham, Russell B., Mumford, Richard A.
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
A Triple Cascade Sequence as a Strategy for the Construction of the Erythrinane Skeleton
Padwa, Albert, Hennig, Rudiger, Kappe, C. Oliver, Reger, Thomas S
Published in Journal of organic chemistry (20.02.1998)
Published in Journal of organic chemistry (20.02.1998)
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Journal Article
2-{2-[3-(Pyridin-3-yloxy)phenyl]-2 H-tetrazol-5-yl}pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist
Huang, Dehua, Poon, Steve F., Chapman, Deborah F., Chung, Janice, Cramer, Merryl, Reger, Thomas S., Roppe, Jeffrey R., Tehrani, Lida, Cosford, Nicholas D.P., Smith, Nicholas D.
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
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Journal Article
Short-Acting T-Type Calcium Channel Antagonists Significantly Modify Sleep Architecture in Rodents
Yang, Zhi-Qiang, Schlegel, Kelly-Ann S, Shu, Youheng, Reger, Thomas S, Cube, Rowena, Mattern, Christa, Coleman, Paul J, Small, Jim, Hartman, George D, Ballard, Jeanine, Tang, Cuyue, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E, Doran, Scott, Fox, Steve V, Garson, Susan L, Li, Yuxing, Kraus, Richard L, Uebele, Victor N, Taylor, Adekemi B, Zeng, Wei, Fang, Wei, Chavez-Eng, Cynthia, Troyer, Matthew D, Luk, Julie Ann, Laethem, Tine, Cook, William O, Renger, John J, Barrow, James C
Published in ACS medicinal chemistry letters (09.12.2010)
Published in ACS medicinal chemistry letters (09.12.2010)
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Journal Article
Characterization of α₄β₁ (CD49d/CD29) on equine leukocytes: Potential utility of a potent α₄β₁ (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction)
Treonze, Kelly M, Alves, Kenneth, Fischer, Paul, Hagmann, William K, Hora, Donald, Kulick, Alison, Vakerich, Ken, Smith, Nicholas D, Lingham, Russell B, Maniar, Salony, Reger, Thomas S, Zunic, Jasmine, Munoz, Benito, Prasit, Peppi, Nicholson, Donald, Si, Qian, Judd, Keith, Nicolich, Susan, Kellerhouse, Patricia, Thompson, Donald, Mumford, Richard A
Published in Veterinary immunology and immunopathology (15.07.2009)
Published in Veterinary immunology and immunopathology (15.07.2009)
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Journal Article
Characterization of alpha(4)beta(1) (CD49d/CD29) on equine leukocytes: potential utility of a potent alpha(4)beta(1) (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction)
Treonze, Kelly M, Alves, Kenneth, Fischer, Paul, Hagmann, William K, Hora, Donald, Kulick, Alison, Vakerich, Ken, Smith, Nicholas D, Lingham, Russell B, Maniar, Salony, Reger, Thomas S, Zunic, Jasmine, Munoz, Benito, Prasit, Peppi, Nicholson, Donald, Si, Qian, Judd, Keith, Nicolich, Susan, Kellerhouse, Patricia, Thompson, Donald, Mumford, Richard A
Published in Veterinary immunology and immunopathology (15.07.2009)
Published in Veterinary immunology and immunopathology (15.07.2009)
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Journal Article
Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia
Smith, Nicholas D., Reger, Thomas S., Payne, Joseph, Zunic, Jasmine, Lorrain, Dan, Correa, Lucie, Stock, Nicholas, Cramer, Merryl, Chen, Weichao, Yang, Jennifer, Prasit, Peppi, Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
Published in Bioorganic & medicinal chemistry letters (01.07.2005)
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Journal Article