Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery
Rees, Holly A, Komor, Alexis C, Yeh, Wei-Hsi, Caetano-Lopes, Joana, Warman, Matthew, Edge, Albert S B, Liu, David R
Published in Nature communications (06.06.2017)
Published in Nature communications (06.06.2017)
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Journal Article
In vivo base editing of post-mitotic sensory cells
Yeh, Wei-Hsi, Chiang, Hao, Rees, Holly A, Edge, Albert S B, Liu, David R
Published in Nature communications (05.06.2018)
Published in Nature communications (05.06.2018)
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Journal Article
Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
Yu, Yi, Leete, Thomas C, Born, David A, Young, Lauren, Barrera, Luis A, Lee, Seung-Joo, Rees, Holly A, Ciaramella, Giuseppe, Gaudelli, Nicole M
Published in Nature communications (28.04.2020)
Published in Nature communications (28.04.2020)
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Journal Article
Analysis and minimization of cellular RNA editing by DNA adenine base editors
Rees, Holly A, Wilson, Christopher, Doman, Jordan L, Liu, David R
Published in Science advances (01.05.2019)
Published in Science advances (01.05.2019)
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Journal Article
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
Gaudelli, Nicole M, Komor, Alexis C, Rees, Holly A, Packer, Michael S, Badran, Ahmed H, Bryson, David I, Liu, David R
Published in Nature (London) (23.11.2017)
Published in Nature (London) (23.11.2017)
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Journal Article
Programmable base editing of AT to GC in genomic DNA without DNA cleavage
Gaudelli, Nicole M, Komor, Alexis C, Rees, Holly A, Packer, Michael S, Badran, Ahmed H, Bryson, David I, Liu, David R
Published in Nature (London) (23.11.2017)
Published in Nature (London) (23.11.2017)
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Journal Article
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
Hu, Johnny H, Miller, Shannon M, Geurts, Maarten H, Tang, Weixin, Chen, Liwei, Sun, Ning, Zeina, Christina M, Gao, Xue, Rees, Holly A, Lin, Zhi, Liu, David R
Published in Nature (London) (05.04.2018)
Published in Nature (London) (05.04.2018)
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Journal Article
Continuous evolution of SpCas9 variants compatible with non-G PAMs
Miller, Shannon M, Wang, Tina, Randolph, Peyton B, Arbab, Mandana, Shen, Max W, Huang, Tony P, Matuszek, Zaneta, Newby, Gregory A, Rees, Holly A, Liu, David R
Published in Nature biotechnology (01.04.2020)
Published in Nature biotechnology (01.04.2020)
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Journal Article
Directed evolution of adenine base editors with increased activity and therapeutic application
Gaudelli, Nicole M, Lam, Dieter K, Rees, Holly A, Solá-Esteves, Noris M, Barrera, Luis A, Born, David A, Edwards, Aaron, Gehrke, Jason M, Lee, Seung-Joo, Liquori, Alexander J, Murray, Ryan, Packer, Michael S, Rinaldi, Conrad, Slaymaker, Ian M, Yen, Jonathan, Young, Lauren E, Ciaramella, Giuseppe
Published in Nature biotechnology (01.07.2020)
Published in Nature biotechnology (01.07.2020)
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Journal Article
Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues
Krishnan, Yamini, Rees, Holly A., Rossitto, Christina P., Kim, Si-Eun, Hung, Han-Hwa K., Frank, Eliot H., Olsen, Bradley D., Liu, David R., Hammond, Paula T., Grodzinsky, Alan J.
Published in Biomaterials (01.11.2018)
Published in Biomaterials (01.11.2018)
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Journal Article
CRISPR-derived genome editing therapies: Progress from bench to bedside
Rees, Holly A., Minella, Alex C., Burnett, Cameron A., Komor, Alexis C., Gaudelli, Nicole M.
Published in Molecular therapy (03.11.2021)
Published in Molecular therapy (03.11.2021)
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Journal Article
Structural and evolutionary versatility in protein complexes with uneven stoichiometry
Marsh, Joseph A, Rees, Holly A, Ahnert, Sebastian E, Teichmann, Sarah A
Published in Nature communications (16.03.2015)
Published in Nature communications (16.03.2015)
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Journal Article