Regioselective synthesis of 4-(2-alkyl-5-methyl-2 H-pyrazol-3-yl)-piperidines
Dirat, Olivier, Clipson, Alex, Elliott, Jason M., Garrett, Sasha, Brian Jones, A., Reader, Michael, Shaw, Duncan
Published in Tetrahedron letters (13.03.2006)
Published in Tetrahedron letters (13.03.2006)
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A Fragment-Derived Clinical Candidate for Antagonism of X‑Linked and Cellular Inhibitor of Apoptosis Proteins: 1‑(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl‑1H,2H,3H‑pyrrolo[3,2‑b]pyridin-1-yl)-2-[(2R,5R)‑5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)
Johnson, Christopher N., Ahn, Jong Sook, Buck, Ildiko M., Chiarparin, Elisabetta, Day, James E. H., Hopkins, Anna, Howard, Steven, Lewis, Edward J., Martins, Vanessa, Millemaggi, Alessia, Munck, Joanne M., Page, Lee W., Peakman, Torren, Reader, Michael, Rich, Sharna J., Saxty, Gordon, Smyth, Tomoko, Thompson, Neil T., Ward, George A., Williams, Pamela A., Wilsher, Nicola E., Chessari, Gianni
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Journal Article
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP)
Tamanini, Emiliano, Buck, Ildiko M, Chessari, Gianni, Chiarparin, Elisabetta, Day, James E. H, Frederickson, Martyn, Griffiths-Jones, Charlotte M, Hearn, Keisha, Heightman, Tom D, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Peakman, Torren, Reader, Michael, Rich, Sharna J, Ward, George A, Williams, Pamela A, Wilsher, Nicola E
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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Journal Article
ERK 억제제의 제조 방법
KHATRI HEM RAJ, JOHNSON MATTHEW, LATHBURY DAVID CHARLES, DAVAR NIPUN, SCOTT IAN, BODHURI PRABHUDAS, READER MICHAEL
Year of Publication 16.02.2024
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Year of Publication 16.02.2024
Patent
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase‑2 (SHP2)
Day, James E. H., Berdini, Valerio, Castro, Joan, Chessari, Gianni, Davies, Thomas G., Day, Philip J., St. Denis, Jeffrey D., Fujiwara, Hideto, Fukaya, Satoshi, Hamlett, Christopher C. F., Hearn, Keisha, Hiscock, Steven D., Holvey, Rhian S., Ito, Satoru, Kandola, Navrohit, Kodama, Yasuo, Liebeschuetz, John W., Martins, Vanessa, Matsuo, Kenichi, Mortenson, Paul N., Muench, Sandra, Nakatsuru, Yoko, Ochiiwa, Hiroaki, Palmer, Nicholas, Peakman, Torren, Price, Amanda, Reader, Michael, Rees, David C., Rich, Sharna J., Shah, Alpesh, Shibata, Yoshihiro, Smyth, Tomoko, Twigg, David G., Wallis, Nicola G., Williams, Glyn, Wilsher, Nicola E., Woodhead, Andrew, Shimamura, Tadashi, Johnson, Christopher N.
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Journal Article
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP
Chessari, Gianni, Buck, Ildiko M, Day, James E. H, Day, Philip J, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Miller, Darcey, Reader, Michael, Rees, David C, Rich, Sharna J, Tamanini, Emiliano, Vitorino, Marc, Ward, George A, Williams, Pamela A, Williams, Glyn, Wilsher, Nicola E, Woolford, Alison J.-A
Published in Journal of medicinal chemistry (27.08.2015)
Published in Journal of medicinal chemistry (27.08.2015)
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Journal Article
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)
Johnson, Christopher N, Ahn, Jong Sook, Buck, Ildiko M, Chiarparin, Elisabetta, Day, James E H, Hopkins, Anna, Howard, Steven, Lewis, Edward J, Martins, Vanessa, Millemaggi, Alessia, Munck, Joanne M, Page, Lee W, Peakman, Torren, Reader, Michael, Rich, Sharna J, Saxty, Gordon, Smyth, Tomoko, Thompson, Neil T, Ward, George A, Williams, Pamela A, Wilsher, Nicola E, Chessari, Gianni
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Journal Article
Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2
Heightman, Tom D, Berdini, Valerio, Braithwaite, Hannah, Buck, Ildiko M, Cassidy, Megan, Castro, Juan, Courtin, Aurélie, Day, James E. H, East, Charlotte, Fazal, Lynsey, Graham, Brent, Griffiths-Jones, Charlotte M, Lyons, John F, Martins, Vanessa, Muench, Sandra, Munck, Joanne M, Norton, David, O’Reilly, Marc, Palmer, Nick, Pathuri, Puja, Reader, Michael, Rees, David C, Rich, Sharna J, Richardson, Caroline, Saini, Harpreet, Thompson, Neil T, Wallis, Nicola G, Walton, Hugh, Wilsher, Nicola E, Woolford, Alison J.-A, Cooke, Michael, Cousin, David, Onions, Stuart, Shannon, Jonathan, Watts, John, Murray, Christopher W
Published in Journal of medicinal chemistry (14.06.2018)
Published in Journal of medicinal chemistry (14.06.2018)
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Journal Article
ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK
Munck, Joanne M, Berdini, Valerio, Bevan, Luke, Brothwood, Jessica L, Castro, Juan, Courtin, Aurélie, East, Charlotte, Ferraldeschi, Roberta, Heightman, Tom D, Hindley, Christopher J, Kucia-Tran, Justyna, Lyons, John F, Martins, Vanessa, Muench, Sandra, Murray, Christopher W, Norton, David, O'Reilly, Marc, Reader, Michael, Rees, David C, Rich, Sharna J, Richardson, Caroline J, Shah, Alpesh D, Stanczuk, Lukas, Thompson, Neil T, Wilsher, Nicola E, Woolford, Alison J-A, Wallis, Nicola G
Published in Molecular cancer therapeutics (01.10.2021)
Published in Molecular cancer therapeutics (01.10.2021)
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Journal Article
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2
Heightman, Tom D., Berdini, Valerio, Bevan, Luke, Buck, Ildiko M., Carr, Maria G., Courtin, Aurelie, Coyle, Joseph E., Day, James E. H., East, Charlotte, Fazal, Lynsey, Griffiths-Jones, Charlotte M., Howard, Steven, Kucia-Tran, Justyna, Martins, Vanessa, Muench, Sandra, Munck, Joanne M., Norton, David, O'Reilly, Marc, Palmer, Nicholas, Pathuri, Puja, Peakman, Torren M., Reader, Michael, Rees, David C., Rich, Sharna J., Shah, Alpesh, Wallis, Nicola G., Walton, Hugh, Wilsher, Nicola E., Woolford, Alison J-A, Cooke, Michael, Cousin, David, Onions, Stuart, Shannon, Jonathan, Watts, John, Murray, Christopher W.
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Towards a total synthesis of ulapualide A. Concise synthetic routes to the tris-oxazole ring system and tris-oxazole macrolide core in ulapualides, kabiramides, halichondramides, mycalolides and halishigamides
Chattopadhyay, SK, Kempson, J, McNeil, A, Pattenden, G, Reader, M, Rippon, DE, Waite, D
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2000)
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (01.01.2000)
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The Synthesis of 3,3-Dimethyl Aza- and Diazaindolines Using a Palladium-Catalysed Intramolecular Reductive Cyclisation
Day, James E. H., Frederickson, Martyn, Hogg, Colin, Johnson, Christopher N., Meek, Alistair, Northern, Julian, Reader, Michael, Reid, Gary
Published in Synlett (12.11.2015)
Published in Synlett (12.11.2015)
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The calculation of the uncertainty of the orifice-plate discharge coefficient
Reader-Harris, Michael, Forsyth, Claire, Boussouara, Tariq
Published in Flow measurement and instrumentation (01.12.2021)
Published in Flow measurement and instrumentation (01.12.2021)
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Journal Article
Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models
Squires, Matthew, Ward, George, Saxty, Gordan, Berdini, Valerio, Cleasby, Anne, King, Peter, Angibaud, Patrick, Perera, Tim, Fazal, Lynsey, Ross, Douglas, Jones, Charlotte Griffiths, Madin, Andrew, Benning, Rajdeep K, Vickerstaffe, Emma, O'Brien, Alistair, Frederickson, Martyn, Reader, Michael, Hamlett, Christopher, Batey, Michael A, Rich, Sharna, Carr, Maria, Miller, Darcey, Feltell, Ruth, Thiru, Abarna, Bethell, Susanne, Devine, Lindsay A, Graham, Brent L, Pike, Andrew, Cosme, Jose, Lewis, Edward J, Freyne, Eddy, Lyons, John, Irving, Julie, Murray, Christopher, Newell, David R, Thompson, Neil T
Published in Molecular cancer therapeutics (01.09.2011)
Published in Molecular cancer therapeutics (01.09.2011)
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Journal Article
ERK1/2 억제제로서의 6-피리미딘-이소인돌 유도체
ADAMCZYK BOZENA EWA, LINDLEY COLIN THOMAS, MELLING ROBERT CRAIG, SCARATI MIRKA, WILSHER NICOLA ELIZABETH, READER MICHAEL, BAGULEY PAUL ANTHONY, SAUNDERS MARK HENRY
Year of Publication 20.12.2019
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Year of Publication 20.12.2019
Patent
Discovery of Imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 Subtype Selective Agonists for the Treatment of Anxiety
Russell, Michael G. N, Carling, Robert W, Street, Leslie J, Hallett, David J, Goodacre, Simon, Mezzogori, Elena, Reader, Michael, Cook, Susan M, Bromidge, Frances A, Newman, Robert, Smith, Alison J, Wafford, Keith A, Marshall, George R, Reynolds, David S, Dias, Rebecca, Ferris, Pushpindar, Stanley, Jo, Lincoln, Rachael, Tye, Spencer J, Sheppard, Wayne F. A, Sohal, Bindi, Pike, Andrew, Dominguez, Maria, Atack, John R, Castro, José L
Published in Journal of medicinal chemistry (23.02.2006)
Published in Journal of medicinal chemistry (23.02.2006)
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Journal Article
PYRAZOLYL QUINOXALINE KINASE INHIBITORS
FREYNE EDDY JEAN EDGARD, PAPANIKOS ALEXANDRA, AKKARI RHALID, MEERPOEL LIEVEN, ANGIBAUD PATRICK RENE, EMBRECHTS WERNER CONSTANT JOHAN, LACRAMPE JEAN FERNAND ARMAND, BERDINI VALERIO, WROBLOWSKI BERTHOLD, SAXTY GORDON, WOODHEAD STEVEN JOHN, HAMLETT CHRISTOPHER CHARLES FREDERICK, MEVELLEC LAURENCE ANNE, BESONG GILBERT EBAI, WEERTS JOHAN ERWIN EDMOND, QUEROLLE OLIVIER ALEXIS GEORGES, JOHNSON CHRISTOPHER NORBERT, PASQUIER ELISABETH THERESE JEANNE, GOVAERTS TOM CORNELIS HORTENSE, REES DAVID CHARLES, BONNET PASCAL GHISLAIN ANDRE, PILATTE ISABELLE NOELLE CONSTANCE, PERERA TIMOTHY PIETRO SUREN, READER MICHAEL, URRAY CHRISTOPHER WILLIAM, GILISSEN RONALDUS ARNODUS HENDRIKA JOSEPH
Year of Publication 20.08.2018
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Year of Publication 20.08.2018
Patent
The effect of contaminated orifice plates on the discharge coefficient
Reader-Harris, Michael, Barton, Neil, Hodges, David
Published in Flow measurement and instrumentation (01.06.2012)
Published in Flow measurement and instrumentation (01.06.2012)
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