Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation
van Biljon, Riëtte, van Wyk, Roelof, Painter, Heather J, Orchard, Lindsey, Reader, Janette, Niemand, Jandeli, Llinás, Manuel, Birkholtz, Lyn-Marie
Published in BMC genomics (03.12.2019)
Published in BMC genomics (03.12.2019)
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Journal Article
Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites
Coetzee, Nanika, von Grüning, Hilde, Opperman, Daniel, van der Watt, Mariette, Reader, Janette, Birkholtz, Lyn-Marié
Published in Scientific reports (11.02.2020)
Published in Scientific reports (11.02.2020)
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Journal Article
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
Reader, Janette, van der Watt, Mariëtte E., Taylor, Dale, Le Manach, Claire, Mittal, Nimisha, Ottilie, Sabine, Theron, Anjo, Moyo, Phanankosi, Erlank, Erica, Nardini, Luisa, Venter, Nelius, Lauterbach, Sonja, Bezuidenhout, Belinda, Horatscheck, Andre, van Heerden, Ashleigh, Spillman, Natalie J., Cowell, Anne N., Connacher, Jessica, Opperman, Daniel, Orchard, Lindsey M., Llinás, Manuel, Istvan, Eva S., Goldberg, Daniel E., Boyle, Grant A., Calvo, David, Mancama, Dalu, Coetzer, Theresa L., Winzeler, Elizabeth A., Duffy, James, Koekemoer, Lizette L., Basarab, Gregory, Chibale, Kelly, Birkholtz, Lyn-Marié
Published in Nature communications (11.01.2021)
Published in Nature communications (11.01.2021)
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Journal Article
Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination
Reader, Janette, Botha, Mariëtte, Theron, Anjo, Lauterbach, Sonja B, Rossouw, Claire, Engelbrecht, Dewaldt, Wepener, Melanie, Smit, Annél, Leroy, Didier, Mancama, Dalu, Coetzer, Theresa L, Birkholtz, Lyn-Marie
Published in Malaria journal (22.05.2015)
Published in Malaria journal (22.05.2015)
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Journal Article
H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum
Connacher, Jessica, Josling, Gabrielle A, Orchard, Lindsey M, Reader, Janette, Llinás, Manuel, Birkholtz, Lyn-Marié
Published in Epigenetics & chromatin (01.04.2021)
Published in Epigenetics & chromatin (01.04.2021)
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Journal Article
Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products
Moyo, Phanankosi, Shamburger, William, van der Watt, Mariëtte E., Reader, Janette, de Sousa, Ana Carolina C., Egan, Timothy J., Maharaj, Vinesh J., Bringmann, Gerhard, Birkholtz, Lyn-Marie
Published in International journal for parasitology -- drugs and drug resistance (01.08.2020)
Published in International journal for parasitology -- drugs and drug resistance (01.08.2020)
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Journal Article
Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer
Abacha, Yabalu Z, Forkuo, Arnold Donkor, Gbedema, Stephen Y, Mittal, Nimisha, Ottilie, Sabine, Rocamora, Frances, Winzeler, Elizabeth A, van Schalkwyk, Donelly A, Kelly, John M, Taylor, Martin C, Reader, Janette, Birkholtz, Lyn-Marie, Lisgarten, David R, Cockcroft, Jeremy K, Lisgarten, John N, Palmer, Rex A, Talbert, Rosemary C, Shnyder, Steven D, Wright, Colin W
Published in Frontiers in pharmacology (26.04.2022)
Published in Frontiers in pharmacology (26.04.2022)
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Journal Article
The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside
Gibhard, Liezl, Coertzen, Dina, Reader, Janette, van der Watt, Mariëtte E, Birkholtz, Lyn-Marie, Wong, Ho Ning, Batty, Kevin T, Haynes, Richard K, Wiesner, Lubbe
Published in Pharmaceutics (03.12.2021)
Published in Pharmaceutics (03.12.2021)
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Journal Article
Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites
Wong, Ho Ning, Padín-Irizarry, Vivian, van der Watt, Mariëtte E., Reader, Janette, Liebenberg, Wilna, Wiesner, Lubbe, Smith, Peter, Eribez, Korina, Winzeler, Elizabeth A., Kyle, Dennis E., Birkholtz, Lyn-Marie, Coertzen, Dina, Haynes, Richard K.
Published in Frontiers in chemistry (10.01.2020)
Published in Frontiers in chemistry (10.01.2020)
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Journal Article
Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites
Beteck, Richard M., Seldon, Ronnett, Coertzen, Dina, van der Watt, Mariëtte E., Reader, Janette, Mackenzie, Jared S., Lamprecht, Dirk A., Abraham, Matthew, Eribez, Korina, Müller, Joachim, Rui, Feng, Zhu, Guang, de Grano, Ruel Valerio, Williams, Ian D., Smit, Frans J., Steyn, Adrie J. C., Winzeler, Elizabeth A., Hemphill, Andrew, Birkholtz, Lyn-Marie, Warner, Digby F., N’Da, David D., Haynes, Richard K.
Published in Communications chemistry (02.10.2018)
Published in Communications chemistry (02.10.2018)
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Journal Article
Anthracene-Polyamine Conjugates Inhibit In Vitro Proliferation of Intraerythrocytic Plasmodium falciparum Parasites
NIEMAND, Jandeli, BURGER, Pieter, VERLINDEN, Bianca K, READER, Janette, JOUBERT, Annie M, KAISER, Annette, LOUW, Abraham I, KIRK, Kiaran, PHANSTIEL, Otto, BIRKHOLTZ, Lyn-Marie
Published in Antimicrobial Agents and Chemotherapy (01.06.2013)
Published in Antimicrobial Agents and Chemotherapy (01.06.2013)
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Journal Article
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
Paquet, Tanya, Le Manach, Claire, Cabrera, Diego González, Younis, Yassir, Henrich, Philipp P, Abraham, Tara S, Lee, Marcus C S, Basak, Rajshekhar, Ghidelli-Disse, Sonja, Lafuente-Monasterio, María José, Bantscheff, Marcus, Ruecker, Andrea, Blagborough, Andrew M, Zakutansky, Sara E, Zeeman, Anne-Marie, White, Karen L, Shackleford, David M, Mannila, Janne, Morizzi, Julia, Scheurer, Christian, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Reader, Janette, Botha, Mariette, Dechering, Koen J, Sauerwein, Robert W, Tungtaeng, Anchalee, Vanachayangkul, Pattaraporn, Lim, Chek Shik, Burrows, Jeremy, Witty, Michael J, Marsh, Kennan C, Bodenreider, Christophe, Rochford, Rosemary, Solapure, Suresh M, Jiménez-Díaz, María Belén, Wittlin, Sergio, Charman, Susan A, Donini, Cristina, Campo, Brice, Birkholtz, Lyn-Marie, Hanson, Kirsten K, Drewes, Gerard, Kocken, Clemens H M, Delves, Michael J, Leroy, Didier, Fidock, David A, Waterson, David, Street, Leslie J, Chibale, Kelly
Published in Science translational medicine (26.04.2017)
Published in Science translational medicine (26.04.2017)
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Journal Article
A Dynamic and Combinatorial Histone Code Drives Malaria Parasite Asexual and Sexual Development
von Grüning, Hilde, Coradin, Mariel, Mendoza, Mariel R., Reader, Janette, Sidoli, Simone, Garcia, Benjamin A., Birkholtz, Lyn-Marié
Published in Molecular & cellular proteomics (01.03.2022)
Published in Molecular & cellular proteomics (01.03.2022)
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Journal Article
In vitro dual activity of Aloe marlothii roots and its chemical constituents against Plasmodium falciparum asexual and sexual stage parasites
Mianda, Sephora Mutombo, Invernizzi, Luke, van der Watt, Mariëtte E., Reader, Janette, Moyo, Phanankosi, Birkholtz, Lyn-Marié, Maharaj, Vinesh J.
Published in Journal of ethnopharmacology (28.10.2022)
Published in Journal of ethnopharmacology (28.10.2022)
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Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration
Mbaba, Mziyanda, Golding, Taryn M., Omondi, Reinner O., Mohunlal, Roxanne, Egan, Timothy J., Reader, Janette, Birkholtz, Lyn-Marie, Smith, Gregory S.
Published in European journal of medicinal chemistry (05.05.2024)
Published in European journal of medicinal chemistry (05.05.2024)
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Journal Article
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure–Activity Relationship and In Vivo Oral Efficacy Studies
Dziwornu, Godwin Akpeko, Coertzen, Dina, Leshabane, Meta, Korkor, Constance M, Cloete, Cleavon K, Njoroge, Mathew, Gibhard, Liezl, Lawrence, Nina, Reader, Janette, van der Watt, Mariëtte, Wittlin, Sergio, Birkholtz, Lyn-Marie, Chibale, Kelly
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Novel 3‑Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model
Mambwe, Dickson, Korkor, Constance M., Mabhula, Amanda, Ngqumba, Zama, Cloete, Cleavon, Kumar, Malkeet, Barros, Paula Ladeia, Leshabane, Meta, Coertzen, Dina, Taylor, Dale, Gibhard, Liezl, Njoroge, Mathew, Lawrence, Nina, Reader, Janette, Moreira, Diogo Rodrigo, Birkholtz, Lyn-Marie, Wittlin, Sergio, Egan, Timothy J., Chibale, Kelly
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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