Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors
Shuttleworth, S J, Silva, F A, Cecil, A R L, Tomassi, C D, Hill, T J, Raynaud, F I, Clarke, P A, Workman, P
Published in Current medicinal chemistry (01.06.2011)
Published in Current medicinal chemistry (01.06.2011)
Get more information
Journal Article
Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
MOORE, A. S, FAISAL, A, MIRABELLA, F, SWANSBURY, J, PEARSON, Adj, WORKMAN, P, BLAGG, J, RAYNAUD, F. I, ECCLES, S. A, LINARDOPOULOS, S, GONZALEZ DE CASTRO, D, BAVETSIAS, V, SUN, C, ATRASH, B, VALENTI, M, DE HAVEN BRANDON, A, AVERY, S, MAIR, D
Published in Leukemia (01.07.2012)
Published in Leukemia (01.07.2012)
Get full text
Journal Article
Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026
NUTLEY, B. P, SMITH, N. F, HAYES, A, KELLAND, L. R, BRUNTON, L, GOLDING, B. T, SMITH, G. C. M, MARTIN, N. M. B, WORKMAN, P, RAYNAUD, F. I
Published in British journal of cancer (31.10.2005)
Published in British journal of cancer (31.10.2005)
Get full text
Journal Article
Cross-platform Q-TOF validation of global exo-metabolomic analysis: Application to human glioblastoma cells treated with the standard PI 3-Kinase inhibitor LY294002
Pandher, R., Ducruix, C., Eccles, S.A., Raynaud, F.I.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.05.2009)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.05.2009)
Get full text
Journal Article
A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer
Kolinsky, M.P., Rescigno, P., Bianchini, D., Zafeiriou, Z., Mehra, N., Mateo, J., Michalarea, V., Riisnaes, R., Crespo, M., Figueiredo, I., Miranda, S., Nava Rodrigues, D., Flohr, P., Tunariu, N., Banerji, U., Ruddle, R., Sharp, A., Welti, J., Lambros, M., Carreira, S., Raynaud, F.I., Swales, K.E., Plymate, S., Luo, J., Tovey, H., Porta, N., Slade, R., Leonard, L., Hall, E., de Bono, J.S.
Published in Annals of oncology (01.05.2020)
Published in Annals of oncology (01.05.2020)
Get full text
Journal Article
Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer
Basu, B., Krebs, M.G., Sundar, R., Wilson, R.H., Spicer, J., Jones, R., Brada, M., Talbot, D.C., Steele, N., Ingles Garces, A.H., Brugger, W., Harrington, E.A., Evans, J., Hall, E., Tovey, H., de Oliveira, F.M., Carreira, S., Swales, K., Ruddle, R., Raynaud, F.I., Purchase, B., Dawes, J.C., Parmar, M., Turner, A.J., Tunariu, N., Banerjee, S., de Bono, J.S., Banerji, U.
Published in Annals of oncology (01.09.2018)
Published in Annals of oncology (01.09.2018)
Get full text
Journal Article
cis-Amminedichloro(2-methylpyridine) platinum(II) (AMD473), a novel sterically hindered platinum complex: in vivo activity, toxicology, and pharmacokinetics in mice
RAYNAUD, F. I, BOXALL, F. E, GODDARD, P. M, VALENTI, M, JONES, M, MURRER, B. A, ABRAMS, M, KELLAND, L. R
Published in Clinical cancer research (01.11.1997)
Get full text
Published in Clinical cancer research (01.11.1997)
Journal Article
Metabolic studies of an orally active platinum anticancer drug by liquid chromatography-electrospray ionization mass spectrometry
Poon, G.K., Raynaud, F.I., Mistry, P., Odell, D.E., Kelland, L.R., Harrap, K.R., Barnard, C.F.J., Murrer, B.A.
Published in Journal of Chromatography A (29.09.1995)
Published in Journal of Chromatography A (29.09.1995)
Get full text
Journal Article
A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy
LEE, C. P, PAYNE, G. S, TRACY, M, MCNAMARA, J, SEDDON, B, LEACH, M. O, WORKMAN, P, JUDSON, I, OREGIONI, A, RUDDLE, R, TAN, S, RAYNAUD, F. I, EATON, D, CAMPBELL, M. J, CROSS, K, HALBERT, G
Published in British journal of cancer (01.12.2009)
Published in British journal of cancer (01.12.2009)
Get full text
Journal Article
Pharmacokinetics of G3139, a Phosphorothioate Oligodeoxynucleotide Antisense to bcl-2, after Intravenous Administration or Continuous Subcutaneous Infusion to Mice
Raynaud, F I, Orr, R M, Goddard, P M, Lacey, H A, Lancashire, H, Judson, I R, Beck, T, Bryan, B, Cotter, F E
Published in The Journal of pharmacology and experimental therapeutics (01.04.1997)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.04.1997)
Journal Article
Discovery and validation of biomarkers to support clinical development of NXP800: A first-in-class orally active, small-molecule HSF1 pathway inhibitor
Workman, P., Clarke, P.A., Te Poele, R., Powers, M., Box, G., De Billy, E., De Haven Brandon, A., Hallsworth, A., Hayes, A., McCann, H., Sharp, S., Valenti, M., Raynaud, F.I., Eccles, S.A., Cheeseman, M., Jones, K.
Published in European journal of cancer (1990) (01.10.2022)
Published in European journal of cancer (1990) (01.10.2022)
Get full text
Journal Article
Preclinical pharmacology of 1069C85, a novel tubulin binder
Raynaud, F I, Kelland, L R, Walton, M I, Judson, I R
Published in Cancer chemotherapy and pharmacology (1994)
Published in Cancer chemotherapy and pharmacology (1994)
Get more information
Journal Article
Drugging the PI3 kinome
Workman, Paul, Clarke, Paul A, Guillard, Sandrine, Raynaud, Florence I
Published in Nature biotechnology (01.07.2006)
Published in Nature biotechnology (01.07.2006)
Get full text
Journal Article
Cross-platform Q-TOF validation of global exo-metabolomic analysis: Application to human glioblastoma cells treated with the standard PI 3-Kinase inhibitor LY294002: Quantitative Analysis of Biomarkers by LC-MS/MS
PANDHER, R, DUCRUIX, C, ECCLES, S. A, RAYNAUD, F. I
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2009)
Get full text
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2009)
Journal Article
Mini-review: discovery and development of platinum complexes designed to circumvent cisplatin resistance
Kelland, Lloyd R., Sharp, Swee Y., O’Neill, Ciaran F., Raynaud, Florence I., Beale, Philip J., Judson, Ian R.
Published in Journal of inorganic biochemistry (01.10.1999)
Published in Journal of inorganic biochemistry (01.10.1999)
Get full text
Journal Article