Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis
Slamova, Ivana, Adib, Rozita, Ellmerich, Stephan, Golos, Michal R., Gilbertson, Janet A., Botcher, Nicola, Canetti, Diana, Taylor, Graham W., Rendell, Nigel, Tennent, Glenys A., Verona, Guglielmo, Porcari, Riccardo, Mangione, P. Patrizia, Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio, Hawkins, Philip N., Al-Shawi, Raya, Simons, J. Paul
Published in Nature communications (07.12.2021)
Published in Nature communications (07.12.2021)
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Novel defect in phosphatidylinositol 4‐kinase type 2‐alpha (PI4K2A) at the membrane‐enzyme interface is associated with metabolic cutis laxa
Mohamed, Miski, Gardeitchik, Thatjana, Balasubramaniam, Shanti, Guerrero‐Castillo, Sergio, Dalloyaux, Daisy, Kraaij, Sanne, Venselaar, Hanka, Hoischen, Alexander, Urban, Zsolt, Brandt, Ulrich, Al‐Shawi, Raya, Simons, J. Paul, Frison, Michele, Ngu, Lock‐Hock, Callewaert, Bert, Spelbrink, Hans, Kallemeijn, Wouter W., Aerts, Johannes M. F. G., Waugh, Mark G., Morava, Eva, Wevers, Ron A.
Published in Journal of inherited metabolic disease (01.11.2020)
Published in Journal of inherited metabolic disease (01.11.2020)
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Journal Article
Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology
Izco, María, Blesa, Javier, Schleef, Martin, Schmeer, Marco, Porcari, Riccardo, Al-Shawi, Raya, Ellmerich, Stephan, de Toro, María, Gardiner, Chris, Seow, Yiqi, Reinares-Sebastian, Alejandro, Forcen, Raquel, Simons, J. Paul, Bellotti, Vittorio, Cooper, J. Mark, Alvarez-Erviti, Lydia
Published in Molecular therapy (04.12.2019)
Published in Molecular therapy (04.12.2019)
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Journal Article
Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice
Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al‐Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El‐Andaloussi, Samir, Alvarez‐Erviti, Lydia
Published in Movement disorders (01.10.2014)
Published in Movement disorders (01.10.2014)
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Journal Article
Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil
Sellers, Katherine J., Elliott, Christina, Jackson, Joshua, Ghosh, Anshua, Ribe, Elena, Rojo, Ana I., Jarosz-Griffiths, Heledd H., Watson, Iain A., Xia, Weiming, Semenov, Mikhail, Morin, Peter, Hooper, Nigel M., Porter, Rod, Preston, Jane, Al-Shawi, Raya, Baillie, George, Lovestone, Simon, Cuadrado, Antonio, Harte, Michael, Simons, Paul, Srivastava, Deepak P., Killick, Richard
Published in Alzheimer's & dementia (01.03.2018)
Published in Alzheimer's & dementia (01.03.2018)
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Journal Article
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity
Parkinson, David B, Feltri, M Laura, Jessen, Kristján R, D'Antonio, Maurizio, Wilton, Daniel K, Mirsky, Rhona, Meijer, Dies, Woodhoo, Ashwin, Radtke, Freddy, Shen, Jie, Droggiti, Anna, Simons, Paul, Alonso, Maria B Duran, Guillemot, Francois, Wrabetz, Lawrence, Turmaine, Mark, Al-Shawi, Raya
Published in Nature neuroscience (01.07.2009)
Published in Nature neuroscience (01.07.2009)
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Journal Article
Pathogenetic mechanisms of amyloid A amyloidosis
Simons, J. Paul, Al-Shawib, Raya, Ellmerich, Stephan, Speck, Ivana, Aslam, Samrina, Hutchinson, Winston L., Mangione, Palma P., Disterer, Petra, Gilbertson, Janet A., Hunt, Toby, Millar, David J., Minogue, Shane, Bodin, Karl, Pepys, Mark B., Hawkins, Philip N.
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2013)
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Journal Article
Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system
Al-Shawi, Raya, Hafner, Angela, Olson, Jessica, Chun, Soyon, Raza, Saba, Thrasivoulou, Christopher, Lovestone, Simon, Killick, Richard, Simons, Paul, Cowen, Timothy
Published in The European journal of neuroscience (01.04.2008)
Published in The European journal of neuroscience (01.04.2008)
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Journal Article
Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation
Khalil, Youssef, Carrino, Sara, Lin, Fujun, Ferlin, Anna, Lad, Heena V, Mazzacuva, Francesca, Falcone, Sara, Rivers, Natalie, Banks, Gareth, Concas, Danilo, Aguilar, Carlos, Haynes, Andrew R, Blease, Andy, Nicol, Thomas, Al-Shawi, Raya, Heywood, Wendy, Potter, Paul, Mills, Kevin, Gale, Daniel P, Clayton, Peter T
Published in International journal of molecular sciences (17.01.2022)
Published in International journal of molecular sciences (17.01.2022)
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Journal Article
Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice
Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al-Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El-Andaloussi, Samir, Alvarez-Erviti, Lydia
Published in Movement disorders (01.10.2014)
Published in Movement disorders (01.10.2014)
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Journal Article
Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells
Lopes da Silva, Mafalda, O'Connor, Marie N, Kriston-Vizi, Janos, White, Ian J, Al-Shawi, Raya, Simons, J Paul, Mössinger, Julia, Haucke, Volker, Cutler, Daniel F
Published in Journal of cell science (15.05.2016)
Published in Journal of cell science (15.05.2016)
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Journal Article
C‐reactive protein is essential for innate resistance to pneumococcal infection
Paul Simons, J., Loeffler, Jutta M., Al‐Shawi, Raya, Ellmerich, Stephan, Hutchinson, Winston L., Tennent, Glenys A., Petrie, Aviva, Raynes, John G., Souza, J. Brian, Lawrence, Rachel A., Read, Kevin D., Pepys, Mark B.
Published in Immunology (01.07.2014)
Published in Immunology (01.07.2014)
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Journal Article
β-AMYLOID SYNAPTOTOXICITY DRIVES β-AMYLOID PRODUCTION
Killick, Richard, Elliott, Christina, Sellers, Katherine, Al-shawi, Raya, Simons, J Paul, Ghosh, Anshua, Jackson, Joshua, Harte, Michael, Hooper, Nigel, Srivastava, Deepak, Lovestone, Simon
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
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Journal Article
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo
Raimondi, Sara, Porcari, Riccardo, Mangione, P. Patrizia, Verona, Guglielmo, Marcoux, Julien, Giorgetti, Sofia, Taylor, Graham W., Ellmerich, Stephan, Ballico, Maurizio, Zanini, Stefano, Pardon, Els, Al-Shawi, Raya, Simons, J. Paul, Corazza, Alessandra, Fogolari, Federico, Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Gillmore, Julian D., Hawkins, Philip N., Valli, Maurizia, Stoppini, Monica, Robinson, Carol V., Steyaert, Jan, Esposito, Gennaro, Bellotti, Vittorio
Published in Scientific reports (21.04.2017)
Published in Scientific reports (21.04.2017)
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Journal Article
Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons
Simons, J. Paul, Al-Shawi, Raya, Minogue, Shane, Waugh, Mark G, Wiedemann, Claudia, Evangelou, Stylianos, Loesch, Andrzej, Sihra, Talvinder S, King, Rosalind, Warner, Thomas T, Hsuan, J. Justin
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2009)
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Journal Article
Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β2-Microglobulin
Halabelian, Levon, Ricagno, Stefano, Giorgetti, Sofia, Santambrogio, Carlo, Barbiroli, Alberto, Pellegrino, Sara, Achour, Adnane, Grandori, Rita, Marchese, Loredana, Raimondi, Sara, Mangione, P. Patrizia, Esposito, Gennaro, Al-Shawi, Raya, Simons, J. Paul, Speck, Ivana, Stoppini, Monica, Bolognesi, Martino, Bellotti, Vittorio
Published in The Journal of biological chemistry (07.02.2014)
Published in The Journal of biological chemistry (07.02.2014)
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Journal Article
Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo
Al-Shawi, Raya, Tennent, Glenys A., Millar, David J., Richard-Londt, Angela, Brandner, Sebastian, Werring, David J., Simons, J. Paul, Pepys, Mark B.
Published in Open biology (01.02.2016)
Published in Open biology (01.02.2016)
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Journal Article
Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity
Kimura, Atsuko, Stevenson, Paula L., Carter, Roderick N., MacColl, Gavin, French, Karen L., Paul Simons, J., Al-Shawi, Raya, Kelly, Valerie, Chapman, Karen E., Holmes, Megan C.
Published in The European journal of neuroscience (01.07.2009)
Published in The European journal of neuroscience (01.07.2009)
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Journal Article
Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system
Al-Shawi, Raya, Hafner, Angela, Olsen, Jessica, Chun, Soyon, Raza, Saba, Thrasivoulou, Christopher, Lovestone, Simon, Killick, Richard, Simons, Paul, Cowen, Timothy
Published in The European journal of neuroscience (01.11.2008)
Published in The European journal of neuroscience (01.11.2008)
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Journal Article
Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development
Al-Shawi, R, Ashton, S V, Underwood, C, Simons, J P
Published in Development genes and evolution (01.04.2001)
Published in Development genes and evolution (01.04.2001)
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