Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1
Najjar, Malek, Suebsuwong, Chalada, Ray, Soumya S., Thapa, Roshan J., Maki, Jenny L., Nogusa, Shoko, Shah, Saumil, Saleh, Danish, Gough, Peter J., Bertin, John, Yuan, Junying, Balachandran, Siddharth, Cuny, Gregory D., Degterev, Alexei
Published in Cell reports (Cambridge) (24.03.2015)
Published in Cell reports (Cambridge) (24.03.2015)
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Journal Article
Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates
Duvall, Jeremy R., Thomas, Joshua D., Bukhalid, Raghida A., Catcott, Kalli C., Bentley, Keith W., Collins, Scott D., Eitas, Timothy, Jones, Brian D., Kelleher, Eugene W., Lancaster, Kelly, Protopopova, Marina, Ray, Soumya S., Ter-Ovanesyan, Elena, Xu, Ling, Yang, Liping, Zurita, Jeffrey, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B.
Published in Journal of medicinal chemistry (10.08.2023)
Published in Journal of medicinal chemistry (10.08.2023)
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Journal Article
Structure–activity relationship study of beta-carboline derivatives as haspin kinase inhibitors
Cuny, Gregory D., Ulyanova, Natalia P., Patnaik, Debasis, Liu, Ji-Feng, Lin, Xiangjie, Auerbach, Ken, Ray, Soumya S., Xian, Jun, Glicksman, Marcie A., Stein, Ross L., Higgins, Jonathan M.G.
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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Journal Article
Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH
Kirubakaran, Sivapriya, Gorla, Suresh Kumar, Sharling, Lisa, Zhang, Minjia, Liu, Xiaoping, Ray, Soumya S., MacPherson, Iain S., Striepen, Boris, Hedstrom, Lizbeth, Cuny, Gregory D.
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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Journal Article
Structural Basis for Conformational Plasticity of the Parkinson's Disease-Associated Ubiquitin Hydrolase UCH-L1
Das, Chittaranjan, Hoang, Quyen Q., Kreinbring, Cheryl A., Luchansky, Sarah J., Meray, Robin K., Ray, Soumya S., Lansbury, Peter T., Ringe, Dagmar, Petsko, Gregory A.
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2006)
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Journal Article
Small-Molecule-Mediated Stabilization of Familial Amyotrophic Lateral Sclerosis-Linked Superoxide Dismutase Mutants against Unfolding and Aggregation
Ray, Soumya S., Nowak, Richard J., Brown, Robert H., Lansbury, Peter T., Petsko, Gregory A.
Published in Proceedings of the National Academy of Sciences - PNAS (08.03.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (08.03.2005)
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Journal Article
An Intersubunit Disulfide Bond Prevents in Vitro Aggregation of a Superoxide Dismutase-1 Mutant Linked to Familial Amytrophic Lateral Sclerosis
Ray, Soumya S, Nowak, Richard J, Strokovich, Konstantin, Brown, Robert H, Walz, Thomas, Lansbury, Peter T
Published in Biochemistry (Easton) (04.05.2004)
Published in Biochemistry (Easton) (04.05.2004)
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Journal Article
Are Deep Learning Structural Models Sufficiently Accurate for Free-Energy Calculations? Application of FEP+ to AlphaFold2-Predicted Structures
Beuming, Thijs, Martín, Helena, Díaz-Rovira, Anna M., Díaz, Lucía, Guallar, Victor, Ray, Soumya S.
Published in Journal of chemical information and modeling (26.09.2022)
Published in Journal of chemical information and modeling (26.09.2022)
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Journal Article
Are Deep Learning Structural Models Sufficiently Accurate for Virtual Screening? Application of Docking Algorithms to AlphaFold2 Predicted Structures
Díaz-Rovira, Anna M., Martín, Helena, Beuming, Thijs, Díaz, Lucía, Guallar, Victor, Ray, Soumya S.
Published in Journal of chemical information and modeling (27.03.2023)
Published in Journal of chemical information and modeling (27.03.2023)
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Journal Article
Destabilization of DJ-1 by Familial Substitution and Oxidative Modifications: Implications for Parkinson's Disease
Hulleman, John D, Mirzaei, Hamid, Guigard, Emmanuel, Taylor, Kellie L, Ray, Soumya S, Kay, Cyril M, Regnier, Fred E, Rochet, Jean-Christophe
Published in Biochemistry (Easton) (15.05.2007)
Published in Biochemistry (Easton) (15.05.2007)
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Journal Article
Targeted Degradation of the Oncogenic Phosphatase SHP2
Vemulapalli, Vidyasiri, Donovan, Katherine A, Seegar, Tom C. M, Rogers, Julia M, Bae, Munhyung, Lumpkin, Ryan J, Cao, Ruili, Henke, Matthew T, Ray, Soumya S, Fischer, Eric S, Cuny, Gregory D, Blacklow, Stephen C
Published in Biochemistry (Easton) (31.08.2021)
Published in Biochemistry (Easton) (31.08.2021)
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Journal Article
Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors
Caputo, Samantha, Di Martino, Simona, Cilibrasi, Vincenzo, Tardia, Piero, Mazzonna, Marco, Russo, Debora, Penna, Ilaria, Summa, Maria, Bertozzi, Sine Mandrup, Realini, Natalia, Margaroli, Natasha, Migliore, Marco, Ottonello, Giuliana, Liu, Min, Lansbury, Peter, Armirotti, Andrea, Bertorelli, Rosalia, Ray, Soumya S, Skerlj, Renato, Scarpelli, Rita
Published in Journal of medicinal chemistry (24.12.2020)
Published in Journal of medicinal chemistry (24.12.2020)
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Journal Article
A Possible Therapeutic Target for Lou Gehrig's Disease
Ray, Soumya S., Lansbury, Peter T.
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2004)
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Journal Article
Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors
Suebsuwong, Chalada, Pinkas, Daniel M., Ray, Soumya S., Bufton, Joshua C., Dai, Bing, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
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Journal Article
Improving Binding Specificity of Pharmacological Chaperones That Target Mutant Superoxide Dismutase-1 Linked to Familial Amyotrophic Lateral Sclerosis Using Computational Methods
Nowak, Richard J, Cuny, Gregory D, Choi, Sungwoon, Lansbury, Peter T, Ray, Soumya S
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
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Journal Article