The expanding role of prodrugs in contemporary drug design and development
Rautio, Jarkko, Meanwell, Nicholas A., Di, Li, Hageman, Michael J.
Published in Nature reviews. Drug discovery (01.08.2018)
Published in Nature reviews. Drug discovery (01.08.2018)
Get full text
Journal Article
Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders
Bahadur, Shiv, Pardhi, Dinesh M, Rautio, Jarkko, Rosenholm, Jessica M, Pathak, Kamla
Published in Pharmaceutics (18.12.2020)
Published in Pharmaceutics (18.12.2020)
Get full text
Journal Article
Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma
Srisongkram, Tarapong, Bahrami, Katayun, Järvinen, Juulia, Timonen, Juri, Rautio, Jarkko, Weerapreeyakul, Natthida
Published in International journal of molecular sciences (30.07.2022)
Published in International journal of molecular sciences (30.07.2022)
Get full text
Journal Article
Prodrugs - an efficient way to breach delivery and targeting barriers
Huttunen, Kristiina M, Rautio, Jarkko
Published in Current topics in medicinal chemistry (01.09.2011)
Published in Current topics in medicinal chemistry (01.09.2011)
Get more information
Journal Article
Towards New Delivery Agents for Boron Neutron Capture Therapy: Synthesis and In Vitro Evaluation of a Set of Fluorinated Carbohydrate Derivatives
Matović, Jelena, Järvinen, Juulia, Sokka, Iris K, Imlimthan, Surachet, Aitio, Olli, Sarparanta, Mirkka, Rautio, Jarkko, Ekholm, Filip S
Published in Molecules (Basel, Switzerland) (09.09.2024)
Published in Molecules (Basel, Switzerland) (09.09.2024)
Get full text
Journal Article
Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine
Peura, Lauri, Malmioja, Kalle, Huttunen, Kristiina, Leppänen, Jukka, Hämäläinen, Miia, Forsberg, Markus M., Rautio, Jarkko, Laine, Krista
Published in Pharmaceutical research (01.10.2013)
Published in Pharmaceutical research (01.10.2013)
Get full text
Journal Article
Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT)
Järvinen, Juulia, Pulkkinen, Herkko, Rautio, Jarkko, Timonen, Juri M
Published in Pharmaceutics (23.11.2023)
Published in Pharmaceutics (23.11.2023)
Get full text
Journal Article
Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats
Jalkanen, Aaro J., Ihalainen, Jouni, Lehtonen, Marko, Forsberg, Markus M., Rautio, Jarkko, Huttunen, Kristiina M., Gynther, Mikko
Published in International journal of pharmaceutics (01.03.2021)
Published in International journal of pharmaceutics (01.03.2021)
Get full text
Journal Article
Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7
Pocasap, Piman, Weerapreeyakul, Natthida, Timonen, Juri, Järvinen, Juulia, Leppänen, Jukka, Kärkkäinen, Jussi, Rautio, Jarkko
Published in International journal of molecular sciences (20.03.2020)
Published in International journal of molecular sciences (20.03.2020)
Get full text
Journal Article
Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular Administration Using Design of Experiments
Zingale, Elide, Bonaccorso, Angela, D'Amico, Agata Grazia, Lombardo, Rosamaria, D'Agata, Velia, Rautio, Jarkko, Pignatello, Rosario
Published in Pharmaceutics (01.01.2024)
Published in Pharmaceutics (01.01.2024)
Get full text
Journal Article
Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake
Kärkkäinen, Jussi, Gynther, Mikko, Kokkola, Tarja, Petsalo, Aleksanteri, Auriola, Seppo, Lahtela-Kakkonen, Maija, Laine, Krista, Rautio, Jarkko, Huttunen, Kristiina M.
Published in International journal of pharmaceutics (10.06.2018)
Published in International journal of pharmaceutics (10.06.2018)
Get full text
Journal Article
Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho -Carboranylmethyl-Bearing Glucoconjugates
Matović, Jelena, Järvinen, Juulia, Sokka, Iris K, Imlimthan, Surachet, Raitanen, Jan-Erik, Montaser, Ahmed, Maaheimo, Hannu, Huttunen, Kristiina M, Peräniemi, Sirpa, Airaksinen, Anu J, Sarparanta, Mirkka, Johansson, Mikael P, Rautio, Jarkko, Ekholm, Filip S
Published in Molecular pharmaceutics (04.01.2021)
Published in Molecular pharmaceutics (04.01.2021)
Get full text
Journal Article
Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure
Gynther, Mikko, Peura, Lauri, Vernerová, Monika, Leppänen, Jukka, Kärkkäinen, Jussi, Lehtonen, Marko, Rautio, Jarkko, Huttunen, Kristiina M.
Published in Neurochemical research (01.10.2016)
Published in Neurochemical research (01.10.2016)
Get full text
Journal Article
Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery
Peura, Lauri, Malmioja, Kalle, Laine, Krista, Leppänen, Jukka, Gynther, Mikko, Isotalo, Antti, Rautio, Jarkko
Published in Molecular pharmaceutics (03.10.2011)
Published in Molecular pharmaceutics (03.10.2011)
Get full text
Journal Article
Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835
Krasavin, Mikhail, Lukin, Alexey, Bagnyukova, Daria, Zhurilo, Nikolay, Zahanich, Ihor, Zozulya, Sergey, Ihalainen, Jouni, Forsberg, Markus M., Lehtonen, Marko, Rautio, Jarkko, Moore, Daniel, Tikhonova, Irina G.
Published in Bioorganic & medicinal chemistry (01.11.2016)
Published in Bioorganic & medicinal chemistry (01.11.2016)
Get full text
Journal Article
Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation
Kärkkäinen, Jussi, Laitinen, Tuomo, Markowicz-Piasecka, Magdalena, Montaser, Ahmed, Lehtonen, Marko, Rautio, Jarkko, Gynther, Mikko, Poso, Antti, Huttunen, Kristiina M.
Published in Bioorganic chemistry (01.07.2021)
Published in Bioorganic chemistry (01.07.2021)
Get full text
Journal Article
High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)
Sangthong, Sarita, Weerapreeyakul, Natthida, Lehtonen, Marko, Leppanen, Jukka, Rautio, Jarkko
Published in Journal of functional foods (01.04.2017)
Published in Journal of functional foods (01.04.2017)
Get full text
Journal Article
Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion
Ylikangas, Henna, Peura, Lauri, Malmioja, Kalle, Leppänen, Jukka, Laine, Krista, Poso, Antti, Lahtela-Kakkonen, Maija, Rautio, Jarkko
Published in European journal of pharmaceutical sciences (14.02.2013)
Published in European journal of pharmaceutical sciences (14.02.2013)
Get full text
Journal Article