Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl‑1 Inhibitor (AZD5991) and Other Synthetic Macrocycles
Balazs, Amber Y. S, Carbajo, Rodrigo J, Davies, Nichola L, Dong, Yu, Hird, Alexander W, Johannes, Jeffrey W, Lamb, Michelle L, McCoull, William, Raubo, Piotr, Robb, Graeme R, Packer, Martin J, Chiarparin, Elisabetta
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1
Sundström, Linda, Myhre, Susanna, Sundqvist, Monika, Ahnmark, Andrea, McCoull, William, Raubo, Piotr, Groombridge, Sam D, Polla, Magnus, Nyström, Ann-Christin, Kristensson, Lisbeth, Någård, Mats, Winzell, Maria Sörhede
Published in PloS one (05.12.2017)
Published in PloS one (05.12.2017)
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Synthesis and structure of oxetane containing tripeptide motifs
Powell, Nicola H., Clarkson, Guy J., Notman, Rebecca, Raubo, Piotr, Martin, Nathaniel G., Shipman, Michael
Published in Chemical communications (Cambridge, England) (14.08.2014)
Published in Chemical communications (Cambridge, England) (14.08.2014)
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A Mechanistic Study of the Lewis Base-Directed Cycloaddition of 2‑Pyrones and Alkynylboranes
Crépin, Damien F. P, Harrity, Joseph P. A, Jiang, Julong, Meijer, Anthony J. H. M, Nassoy, Anne-Chloé M. A, Raubo, Piotr
Published in Journal of the American Chemical Society (18.06.2014)
Published in Journal of the American Chemical Society (18.06.2014)
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A Concise Asymmetric Route to Nuphar Alkaloids. A Formal Synthesis of (−)-Deoxynupharidine
Moran, Wesley J, Goodenough, Katharine M, Raubo, Piotr, Harrity, Joseph P. A
Published in Organic letters (18.09.2003)
Published in Organic letters (18.09.2003)
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Diversity-orientated synthesis of macrocyclic heterocycles using a double SNAr approach
Raubo, Piotr, Carbajo, Rodrigo J., McCoull, William, Raubo, Joanna, Thomas, Morgan
Published in Organic & biomolecular chemistry (28.07.2021)
Published in Organic & biomolecular chemistry (28.07.2021)
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Journal Article
Diversity-orientated synthesis of macrocyclic heterocycles using a double S N Ar approach
Raubo, Piotr, Carbajo, Rodrigo J, McCoull, William, Raubo, Joanna, Thomas, Morgan
Published in Organic & biomolecular chemistry (21.07.2021)
Published in Organic & biomolecular chemistry (21.07.2021)
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Journal Article
Diversity-orientated synthesis of macrocyclic heterocycles using a double SAr approach
Raubo, Piotr, Carbajo, Rodrigo J, McCoull, William, Raubo, Joanna, Thomas, Morgan
Published in Organic & biomolecular chemistry (21.07.2021)
Published in Organic & biomolecular chemistry (21.07.2021)
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Solid-Phase Synthesis of Oxetane Modified Peptides
Beadle, Jonathan D, Knuhtsen, Astrid, Hoose, Alex, Raubo, Piotr, Jamieson, Andrew G, Shipman, Michael
Published in Organic letters (16.06.2017)
Published in Organic letters (16.06.2017)
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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the MutantGTPase KRAS(G12C)
Kettle, Jason G., Bagal, Sharan K., Bickerton, Sue, Bodnarchuk, Michael S., Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J., Cassar, Doyle J., Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L., Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J., Liu, Libin, Niedbala, Michael J., Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M., Ross, Sarah, Sanders, Matthew G., Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
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Development of a Novel B‑Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6
McCoull, William, Cheung, Tony, Anderson, Erica, Barton, Peter, Burgess, Jonathan, Byth, Kate, Cao, Qing, Castaldi, M. Paola, Chen, Huawei, Chiarparin, Elisabetta, Carbajo, Rodrigo J, Code, Erin, Cowan, Suzanna, Davey, Paul R, Ferguson, Andrew D, Fillery, Shaun, Fuller, Nathan O, Gao, Ning, Hargreaves, David, Howard, Martin R, Hu, Jun, Kawatkar, Aarti, Kemmitt, Paul D, Leo, Elisabetta, Molina, Daniel M, O’Connell, Nichole, Petteruti, Philip, Rasmusson, Timothy, Raubo, Piotr, Rawlins, Philip B, Ricchiuto, Piero, Robb, Graeme R, Schenone, Monica, Waring, Michael J, Zinda, Michael, Fawell, Stephen, Wilson, David M
Published in ACS chemical biology (16.11.2018)
Published in ACS chemical biology (16.11.2018)
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Impact of oxetane incorporation on the structure and stability of alpha-helical peptides
Jayawant, Eleanor S, Beadle, Jonathan D, Wilkening, Ina, Raubo, Piotr, Shipman, Michael, Notman, Rebecca, Dixon, Ann M
Published in Physical chemistry chemical physics : PCCP (21.11.2020)
Published in Physical chemistry chemical physics : PCCP (21.11.2020)
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Discovery of Pyrazolo[1,5‑a]pyrimidine B‑Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
McCoull, William, Abrams, Roman D, Anderson, Erica, Blades, Kevin, Barton, Peter, Box, Matthew, Burgess, Jonathan, Byth, Kate, Cao, Qing, Chuaqui, Claudio, Carbajo, Rodrigo J, Cheung, Tony, Code, Erin, Ferguson, Andrew D, Fillery, Shaun, Fuller, Nathan O, Gangl, Eric, Gao, Ning, Grist, Matthew, Hargreaves, David, Howard, Martin R, Hu, Jun, Kemmitt, Paul D, Nelson, Jennifer E, O’Connell, Nichole, Prince, D. Bryan, Raubo, Piotr, Rawlins, Philip B, Robb, Graeme R, Shi, Junjie, Waring, Michael J, Whittaker, David, Wylot, Marta, Zhu, Xiahui
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Journal Article
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS(G12C) with Demonstrable CNS Penetration
Kettle, Jason G., Bagal, Sharan K., Barratt, Derek, Bodnarchuk, Michael S., Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J., Cosulich, Sabina, Davies, Michael, Davies, Nichola L., Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J., Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Gonzalez, Miguel A. Cortes, Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnstrom, Peter, Kemmitt, Paul D., Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M., Lamont, Scott, Lewis, Hilary J., Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J., Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R., Ross, Sarah, Sanders, Matthew G., Schou, Magnus, Simpson, Iain, Steward, Oliver
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
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Journal Article
Development of oxetane modified building blocks for peptide synthesis
Roesner, Stefan, Beadle, Jonathan D, Tam, Leo K. B, Wilkening, Ina, Clarkson, Guy J, Raubo, Piotr, Shipman, Michael
Published in Organic & biomolecular chemistry (22.07.2020)
Published in Organic & biomolecular chemistry (22.07.2020)
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