Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis
NARE, Bakela, WRING, Stephen, HUSSAIN, Ali, JARNAGIN, Kurt, JENKS, Matthew, KAISER, Marcel, MERCER, Luke, MEJIA, Elena, NOE, Andy, ORR, Matt, PARHAM, Robin, PLATTNER, Jacob, BACCHI, Cyrus, RANDOLPH, Ryan, RATTENDI, Donna, REWERTS, Cindy, SLIGAR, Jessica, YARLETT, Nigel, DON, Robert, JACOBS, Robert, BEAUDET, Beth, BOWLING, Tana, BRUN, Reto, DAITAO CHEN, DING, Charles, FREUND, Yvonne, GAUKEL, Eric
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
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Trypanocidal Activity of 8-Methyl-5′-{[(Z)-4-Aminobut-2-enyl]-(Methylamino)}Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor
BACCHI, Cyrus J, BARKER, Robert H, RODRIGUEZ, Aixa, HIRTH, Bradford, RATTENDI, Donna, YARLETT, Nigel, HENDRICK, Clifford L, SYBERTZ, Edmund
Published in Antimicrobial Agents and Chemotherapy (01.08.2009)
Published in Antimicrobial Agents and Chemotherapy (01.08.2009)
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Selective Antimicrotubule Activity of N1-Phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against Kinetoplastid Parasites
Werbovetz, Karl A, Sackett, Dan L, Delfín, Dawn, Bhattacharya, Gautam, Salem, Manar, Obrzut, Tomasz, Rattendi, Donna, Bacchi, Cyrus
Published in Molecular pharmacology (01.12.2003)
Published in Molecular pharmacology (01.12.2003)
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Journal Article
Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian Encephalitozoon cuniculi
BACCHI, Cyrus J, YARLETT, Nigel, FACIANE, Evangeline, XIANGDONG BI, RATTENDI, Donna, WEISS, Louis M, WOSTER, Patrick M
Published in Antimicrobial Agents and Chemotherapy (01.06.2009)
Published in Antimicrobial Agents and Chemotherapy (01.06.2009)
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Journal Article
Novel Trypanocidal Analogs of 5′-(Methylthio)-Adenosine
SUFRIN, Janice R, SPIESS, Arthur J, MARASCO, Canio J, RATTENDI, Donna, BACCHI, Cyrus J
Published in Antimicrobial Agents and Chemotherapy (01.01.2008)
Published in Antimicrobial Agents and Chemotherapy (01.01.2008)
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Journal Article
Antitrypanosomal Activity of a New Triazine Derivative, SIPI 1029, In Vitro and in Model Infections
BACCHI, C. J, VARGAS, M, RATTENDI, D, GOLDBERG, B, WEICHENG ZHOU
Published in Antimicrobial Agents and Chemotherapy (01.10.1998)
Published in Antimicrobial Agents and Chemotherapy (01.10.1998)
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Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity
Huang, Tien L., Eynde, Jean Jacques Vanden, Mayence, Annie, Collins, Margaret S., Cushion, Melanie T., Rattendi, Donna, Londono, Indira, Mazumder, Lakshman, Bacchi, Cyrus J., Yarlett, Nigel
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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Journal Article
Trypanocidal Activity of Conformationally Restricted Pentamidine Congeners
Donkor, Isaac O, Huang, Tien L, Tao, Bin, Rattendi, Donna, Lane, Schennella, Vargas, Marc, Goldberg, Burt, Bacchi, Cyrus
Published in Journal of medicinal chemistry (13.03.2003)
Published in Journal of medicinal chemistry (13.03.2003)
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Journal Article
Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug
Huang, Tien L, Bacchi, Cyrus J, Kode, Nageswara R, Zhang, Qiang, Wang, Guangdi, Yartlet, Nigel, Rattendi, Donna, Londono, Indira, Mazumder, Lakshman, Vanden Eynde, Jean Jacques, Mayence, Annie, Donkor, Isaac O
Published in International journal of antimicrobial agents (01.12.2007)
Published in International journal of antimicrobial agents (01.12.2007)
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Journal Article
Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents
ZHILI LI, FENNIE, Michael W, GANEM, Bruce, HANCOCK, Matthew T, KOBASLIJA, Muris, RATTENDI, Donna, BACCHI, Cyrus J, O'SULLIVAN, Mary C
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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Journal Article
Selective Antimicrotubule Activity of N 1-Phenyl-3,5-dinitro- N 4, N 4-di- n -propylsulfanilamide (GB-II-5) against Kinetoplastid Parasites
Werbovetz, Karl A., Sackett, Dan L., Delfín, Dawn, Bhattacharya, Gautam, Salem, Manar, Obrzut, Tomasz, Rattendi, Donna, Bacchi, Cyrus
Published in Molecular pharmacology (01.12.2003)
Published in Molecular pharmacology (01.12.2003)
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Journal Article
Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues
Bacchi, Cyrus J, Rattendi, Donna, Faciane, Evangeline, Yarlett, Nigel, Weiss, Louis M, Frydman, Benjamin, Woster, Patrick, Wei, Benjamin, Marton, Laurence J, Wittner, Murray
Published in Microbiology (Society for General Microbiology) (01.05.2004)
Published in Microbiology (Society for General Microbiology) (01.05.2004)
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Journal Article
Trypanocidal Diarylheptanoids from Aframomum letestuianum
Kamnaing, Pierre, Tsopmo, Apollinaire, Tanifum, Eric A, Tchuendem, Marguerite H. K, Tane, Pierre, Ayafor, Johnson F, Sterner, Olov, Rattendi, Donna, Iwu, Maurice M, Schuster, Brian, Bacchi, Cyrus
Published in Journal of natural products (Washington, D.C.) (01.03.2003)
Published in Journal of natural products (Washington, D.C.) (01.03.2003)
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Journal Article
Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues: Amitochondriate protists
BACCHI, Cyrus J, RATTENDI, Donna, FACIANE, Evangeline, YARLETT, Nigel, WEISS, Louis M, FRYDMAN, Benjamin, WOSTER, Patrick, WEI, Benjamin, MARTON, Laurence J, WITTNER, Murray
Published in Microbiology (Society for General Microbiology) (2004)
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Published in Microbiology (Society for General Microbiology) (2004)
Journal Article
Trypanocidal activity of dicationic compounds related to pentamidine
Donkor, Isaac O, Assefa, Haregewein, Rattendi, Donna, Lane, Schennella, Vargas, Marc, Goldberg, Burt, Bacchi, Cyrus
Published in European journal of medicinal chemistry (01.06.2001)
Published in European journal of medicinal chemistry (01.06.2001)
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Journal Article
Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity
Zou, Yu, Wu, Zhiqian, Sirisoma, Nilantha, Woster, Patrick M, Casero, Robert A, Weiss, Louis M, Rattendi, Donna, Lane, Schennella, Bacchi, Cyrus J
Published in Bioorganic & medicinal chemistry letters (18.06.2001)
Published in Bioorganic & medicinal chemistry letters (18.06.2001)
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Journal Article
Synthesis and Evaluation of Analogues of 5‘-([(Z)-4-Amino-2-butenyl]methylamino)-5‘-deoxyadenosine as Inhibitors of Tumor Cell Growth, Trypanosomal Growth, and HIV-1 Infectivity
Marasco, Canio J, Kramer, Debora L, Miller, John, Porter, Carl W, Bacchi, Cyrus J, Rattendi, Donna, Kucera, Louis, Iyer, Nathan, Bernacki, Ralph, Pera, Paula, Sufrin, Janice R
Published in Journal of medicinal chemistry (07.11.2002)
Published in Journal of medicinal chemistry (07.11.2002)
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Journal Article
In situ kinetic characterization of methylthioadenosine transport by the adenosine transporter (P2) of the African Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense33Abbreviations: AdoMet, S-adenosylmethionine; MTA, methylthioadenosine; MTR-1-P, methylthioribose-1-phosphate; KMTB, ketomethylthiobutyrate; HETA, 5′-deoxy-5′-hydroxyethylthioadenosine; and PBSG, 0.05 M phosphate-buffered 0.9% saline (pH 8.0) + 7% glucose
Goldberg, Burt, Rattendi, Donna, Lloyd, David, Sufrin, Janice R, Bacchi, Cyrus J
Published in Biochemical pharmacology (01.02.2001)
Published in Biochemical pharmacology (01.02.2001)
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