The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer
Deegen, Petra, Thomas, Oliver, Nolan-Stevaux, Olivier, Li, Shyun, Wahl, Joachim, Bogner, Pamela, Aeffner, Famke, Friedrich, Matthias, Liao, Michael Z, Matthes, Katja, Rau, Doris, Rattel, Benno, Raum, Tobias, Kufer, Peter, Coxon, Angela, Bailis, Julie M
Published in Clinical cancer research (15.05.2021)
Published in Clinical cancer research (15.05.2021)
Get full text
Journal Article
Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule
Pham, Elizabeth, Friedrich, Matthias, Aeffner, Famke, Lutteropp, Michael, Mariano, Natalie F, Deegen, Petra, Dahlhoff, Christoph, Vogel, Franziska, Bluemel, Claudia, Harrold, John M, Brandl, Christian, Grinberg, Natalia, Rattel, Benno, Coxon, Angela, Bailis, Julie M
Published in Molecular cancer therapeutics (01.10.2021)
Published in Molecular cancer therapeutics (01.10.2021)
Get full text
Journal Article
T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells
Lutterbuese, Ralf, Raum, Tobias, Kischel, Roman, Hoffmann, Patrick, Mangold, Susanne, Rattel, Benno, Friedrich, Matthias, Thomas, Oliver, Lorenczewski, Grit, Rau, Doris, Schaller, Evelyne, Herrmann, Ines, Wolf, Andreas, Urbig, Thomas, Baeuerle, Patrick A., Kufer, Peter, Ravetch, Jeffrey V.
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2010)
Get full text
Journal Article
Challenges of non-clinical safety testing for biologics: A Report of the 9th BioSafe European Annual General Membership Meeting
Kissner, Thomas, Blaich, Guenter, Baumann, Andreas, Kronenberg, Sven, Hey, Adam, Kiessling, Andrea, Schmitt, Petra M., Driessen, Wouter, Carrez, Chantal, Kramer, Daniel, Fretland, Jennifer, Richter, Wolfgang F., Paehler, Tobias, Hopfer, Ulrike, Rattel, Benno
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
Get full text
Journal Article
Preclinical antitumor activity of the oral platinum analog satraplatin
WOSIKOWSKI, Katja, LAMPHERE, Lou, UNTEREGGER, Gerhard, JUNG, Volker, KAPLAN, Faith, XU, Jimmy P, RATTEL, Benno, CALIGIURI, Maureen
Published in Cancer chemotherapy and pharmacology (01.09.2007)
Published in Cancer chemotherapy and pharmacology (01.09.2007)
Get full text
Journal Article
In Vitro and in Vivo Antitumor Activity of Methotrexate Conjugated to Human Serum Albumin in Human Cancer Cells
WOSIKOWSKI, Katja, BIEDERMANN, Elfi, RATTEL, Benno, BREITER, Norbert, JANK, Peter, LOSER, Roland, JANSEN, Gerrit, PETERS, Godefridus J
Published in Clinical cancer research (01.05.2003)
Get full text
Published in Clinical cancer research (01.05.2003)
Journal Article
Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells
Nagy, Zoltan A, Hubner, Bernd, Löhning, Corinna, Rauchenberger, Robert, Reiffert, Silke, Thomassen-Wolf, Elisabeth, Zahn, Stefan, Leyer, Sigmar, Schier, Eva M, Zahradnik, Angelika, Brunner, Christoph, Lobenwein, Kurt, Rattel, Benno, Stanglmaier, Michael, Hallek, Michael, Wing, Mark, Anderson, Steve, Dunn, Matt, Kretzschmar, Titus, Tesar, Michael
Published in Nature medicine (01.08.2002)
Published in Nature medicine (01.08.2002)
Get full text
Journal Article
An Innovative Approach to Optimize First-In-Human Minimal Anticipated Biological Effect Level Based Starting Dose in Oncology Trials for Bispecific T-Cell Engagers: Experience from A Solid Tumor Bispecific T-Cell Engager
Zhou, Di, Kischel, Roman, Stienen, Sabine, Townsley, Danielle, Sternjak, Alexander, Lutteropp, Michael, Bailis, Julie, Friedrich, Matthias, Rattel, Benno, Mehta, Khamir, Upreti, Vijay V
Published in Clinical pharmacology and therapeutics (16.09.2024)
Published in Clinical pharmacology and therapeutics (16.09.2024)
Get more information
Journal Article
Preclinical Assessment of AMG 596, a Bispecific T-cell Engager (BiTE) Immunotherapy Targeting the Tumor-specific Antigen EGFRvIII
Sternjak, Alexander, Lee, Fei, Thomas, Oliver, Balazs, Mercedesz, Wahl, Joachim, Lorenczewski, Grit, Ullrich, Ines, Muenz, Markus, Rattel, Benno, Bailis, Julie M, Friedrich, Matthias
Published in Molecular cancer therapeutics (01.05.2021)
Published in Molecular cancer therapeutics (01.05.2021)
Get full text
Journal Article
Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia
Friedrich, Matthias, Henn, Anja, Raum, Tobias, Bajtus, Monika, Matthes, Katja, Hendrich, Larissa, Wahl, Joachim, Hoffmann, Patrick, Kischel, Roman, Kvesic, Majk, Slootstra, Jerry W, Baeuerle, Patrick A, Kufer, Peter, Rattel, Benno
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
Get full text
Journal Article
Current nonclinical approaches for immune assessments of immuno-oncology biotherapeutics
Grimaldi, Christine, Ibraghimov, Alex, Kiessling, Andrea, Rattel, Benno, Ji, Changhua, Fuller, Claudette L., Brennan, Frank R., Regenass-Lechner, Franziska, Shenton, Jacintha, Price, Karen D., Piché, Marie-Soleil, Steeves, Meredith A., Prell, Rodney, Dudal, Sherri, Kronenberg, Sven, Freebern, Wendy, Blanset, Diann
Published in Drug discovery today (01.02.2023)
Published in Drug discovery today (01.02.2023)
Get full text
Journal Article
Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-Bispecific BiTE antibody cross-reactive with non-human primate antigens
Friedrich, Matthias, Raum, Tobias, Lutterbuese, Ralf, Voelkel, Markus, Deegen, Petra, Rau, Doris, Kischel, Roman, Hoffmann, Patrick, Brandl, Christian, Schuhmacher, Joachim, Mueller, Peter, Finnern, Ricarda, Fuergut, Melanie, Zopf, Dieter, Slootstra, Jerry W, Baeuerle, Patrick A, Rattel, Benno, Kufer, Peter
Published in Molecular cancer therapeutics (01.12.2012)
Published in Molecular cancer therapeutics (01.12.2012)
Get full text
Journal Article
Abstract 3364: Preclinical evaluation of BiTE®immune therapy targeting MUC17 or CLDN18.2 for gastric cancer
Bailis, Julie M., Lutterbuese, Petra, Thomas, Oliver, Locher, Kathrin, Harrold, John, Boyle, Michael, Wahl, Joachim, Li, Shyun, Sternjak, Alexander, Henn, Anja, Dahlhoff, Christoph, Naegele, Virginie, Rattel, Benno, Raum, Tobias, Coxon, Angela
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Preclinical evaluation of AMG 160, a next-generation bispecific T cell engager (BiTE) targeting the prostate-specific membrane antigen PSMA for metastatic castration-resistant prostate cancer (mCRPC)
Bailis, Julie, Deegen, Petra, Thomas, Oliver, Bogner, Pamela, Wahl, Joachim, Liao, Mike, Li, Shyun, Matthes, Katja, Nägele, Virginie, Rau, Doris, Rattel, Benno, Raum, Tobias, Kufer, Peter, Coxon, Angela
Published in Journal of clinical oncology (01.03.2019)
Published in Journal of clinical oncology (01.03.2019)
Get full text
Journal Article
BCMA CD3 T BCMA and CD3 Bispecific T Cell Engaging Antibody Constructs
RAUM TOBIAS, POMPE CORNELIUS, BROZY JOHANNES, BOGNER PAMELA, WOLF ANDREAS, HOFFMANN PATRICK, MUENZ MARKUS, KUFER PETER, RATTEL BENNO, FRIEDRICH MATTHIAS
Year of Publication 05.08.2024
Get full text
Year of Publication 05.08.2024
Patent
Nonclinical Development of Biologics: Integrating Safety, Pharmacokinetics, and Pharmacodynamics to Create Smarter and More Flexible Nonclinical Safety Programs Optimizing Animal Use
Hey, Adam, Baumann, Andreas, Kronenberg, Sven, Blaich, Guenter, Mohl, Silke, Fagg, Rajni, Ulrich, Peter, Rattel, Benno, Richter, Wolfgang F, Kiessling, Andrea, Weir, Lucinda
Published in International journal of toxicology (01.05.2021)
Published in International journal of toxicology (01.05.2021)
Get more information
Journal Article
BI 836909, a Novel Bispecific T Cell Engager for the Treatment of Multiple Myeloma Induces Highly Specific and Efficacious Lysis of Multiple Myeloma Cells in Vitro and Shows Anti-Tumor Activity in Vivo
Hipp, Susanne, Deegen, Petra, Wahl, Joachim, Blanset, Diann, Thomas, Oliver, Rattel, Benno, Adam, Paul, Friedrich, Matthias
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
Get full text
Journal Article
Abstract 3630: Preclinical evaluation of a BiTE® antibody construct with extended half-life that targets the tumor differentiation marker mesothelin
Sternjak, Alexander, Lee, Fei, Wahl, Joachim, Rock, Dan, Thomas, Oliver, Stienen, Sabine, Lutterbuese, Ralf, Hoffmann, Patrick, Raum, Tobias, Kufer, Peter, Rattel, Benno, Coxon, Angela, Friedrich, Matthias, Bailis, Julie
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys
Goldstein, Rebecca L., Goyos, Ana, Li, Chi-Ming, Deegen, Petra, Bogner, Pamela, Sternjak, Alexander, Thomas, Oliver, Klinger, Matthias, Wahl, Joachim, Friedrich, Matthias, Rattel, Benno, Lamas, Edwin, Min, Xiaoshan, Sudom, Athena, Farshbaf, Mozhgan, Coxon, Angela, Balazs, Mercedesz, Arvedson, Tara
Published in Blood advances (08.09.2020)
Published in Blood advances (08.09.2020)
Get full text
Journal Article
Abstract 55: Generation of half-life extended anti-CD33 BiTE® antibody constructs compatible with once-weekly dosing
Arvedson, Tara L., Balazs, Mercedesz, Bogner, Pamela, Black, Kurt, Graham, Kevin, Henn, Anja, Friedrich, Matthias, Hoffmann, Patrick, Kischel, Roman, Kufer, Peter, Lutterbuese, Ralf, Muenz, Markus, Raum, Tobias, Rattel, Benno, Rex, Karen, Rock, Dan, Thomas, Oliver, Wahl, Joachim, Wolf, Andreas, Coxon, Angela
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article