Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic
Rossmueller, Gregor, Mirkina, Irina, Maurer, Barbara, Hoeld, Verena, Mayer, Julia, Thiele, Michael, Kerschbaumer, Randolf J, Schinagl, Alexander
Published in Molecular cancer therapeutics (04.05.2023)
Published in Molecular cancer therapeutics (04.05.2023)
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Journal Article
Pretargeted radioimmunotherapy with the novel anti-oxMIF/HSG bispecific antibody ON105 results in significant tumor regression in murine models of cancer
Puchol Tarazona, Alejandro A, Schinagl, Alexander, Mirkina, Irina, Rossmueller, Gregor, Kerschbaumer, Randolf J, Bachmann, Friedmund, Thiele, Michael
Published in Molecular cancer therapeutics (04.09.2024)
Published in Molecular cancer therapeutics (04.09.2024)
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Journal Article
Human anti-macrophage migration inhibitory factor antibodies inhibit growth of human prostate cancer cells in vitro and in vivo
Hussain, Filza, Freissmuth, Michael, Völkel, Dirk, Thiele, Michael, Douillard, Patrice, Antoine, Gerhard, Thurner, Patrick, Ehrlich, Hartmut, Schwarz, Hans-Peter, Scheiflinger, Friedrich, Kerschbaumer, Randolf J
Published in Molecular cancer therapeutics (01.07.2013)
Published in Molecular cancer therapeutics (01.07.2013)
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Journal Article
Role of the Cysteine 81 Residue of Macrophage Migration Inhibitory Factor as a Molecular Redox Switch
Schinagl, Alexander, Kerschbaumer, Randolf J, Sabarth, Nicolas, Douillard, Patrice, Scholz, Peter, Voelkel, Dirk, Hollerweger, Julia C, Goettig, Peter, Brandstetter, Hans, Scheiflinger, Friedrich, Thiele, Michael
Published in Biochemistry (Easton) (06.03.2018)
Published in Biochemistry (Easton) (06.03.2018)
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Journal Article
Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer
Schinagl, Alexander, Thiele, Michael, Douillard, Patrice, Völkel, Dirk, Kenner, Lukas, Kazemi, Zahra, Freissmuth, Michael, Scheiflinger, Friedrich, Kerschbaumer, Randolf J
Published in Oncotarget (08.11.2016)
Published in Oncotarget (08.11.2016)
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Journal Article
Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions
Thiele, Michael, Kerschbaumer, Randolf J, Tam, Frederick W K, Völkel, Dirk, Douillard, Patrice, Schinagl, Alexander, Kühnel, Harald, Smith, Jennifer, McDaid, John P, Bhangal, Gurjeet, Yu, Mei-Ching, Pusey, Charles D, Cook, H Terence, Kovarik, Josef, Magelky, Erica, Bhan, Atul, Rieger, Manfred, Mudde, Geert C, Ehrlich, Hartmut, Jilma, Bernd, Tilg, Herbert, Moschen, Alexander, Terhorst, Cox, Scheiflinger, Friedrich
Published in The Journal of immunology (1950) (01.09.2015)
Published in The Journal of immunology (1950) (01.09.2015)
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Journal Article
Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF
Kerschbaumer, Randolf J., Rieger, Manfred, Völkel, Dirk, Le Roy, Didier, Roger, Thierry, Garbaraviciene, Jurate, Boehncke, Wolf-Henning, Müllberg, Jürgen, Hoet, Rene M., Wood, Clive R., Antoine, Gerhard, Thiele, Michael, Savidis-Dacho, Helga, Dockal, Michael, Ehrlich, Hartmut, Calandra, Thierry, Scheiflinger, Friedrich
Published in The Journal of biological chemistry (02.03.2012)
Published in The Journal of biological chemistry (02.03.2012)
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Journal Article
Pharmacokinetics, disease-modifying activity, and safety of an experimental therapeutic targeting an immunological isoform of macrophage migration inhibitory factor, in rat glomerulonephritis
Höllriegl, Werner, Bauer, Alexander, Baumgartner, Bernhard, Dietrich, Barbara, Douillard, Patrice, Kerschbaumer, Randolf J., Höbarth, Gerald, McKee, Jeffrey S., Schinagl, Alexander, Tam, Frederick W.K., Thiele, Michael, Weber, Alfred, Wolfsegger, Martin, Turecek, Marietta, Muchitsch, Eva-Maria, Scheiflinger, Friedrich, Glantschnig, Helmut
Published in European journal of pharmacology (05.02.2018)
Published in European journal of pharmacology (05.02.2018)
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Journal Article
Cloning, expression, and functional characterization of the von Willebrand factor–cleaving protease (ADAMTS13)
Plaimauer, Barbara, Zimmermann, Klaus, Völkel, Dirk, Antoine, Gerhard, Kerschbaumer, Randolf, Jenab, Pegah, Furlan, Miha, Gerritsen, Helen, Lämmle, Bernhard, Schwarz, Hans Peter, Scheiflinger, Friedrich
Published in Blood (15.11.2002)
Published in Blood (15.11.2002)
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Journal Article
Optimization of an Antibody Light Chain Framework Enhances Expression, Biophysical Properties and Pharmacokinetics
Douillard, Patrice, Freissmuth, Michael, Antoine, Gerhard, Thiele, Michael, Fleischanderl, Daniel, Matthiessen, Peter, Voelkel, Dirk, Kerschbaumer, Randolf J., Scheiflinger, Friedrich, Sabarth, Nicolas
Published in Antibodies (Basel) (06.09.2019)
Published in Antibodies (Basel) (06.09.2019)
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Journal Article
An Antibody Specific for Coagulation Factor IX Enhances the Activity of the Intrinsic Factor X-activating Complex
Kerschbaumer, Randolf J., Riedrich, Klaudia, Kral, Martina, Varadi, Katalin, Dorner, Friedrich, Rosing, Jan, Scheiflinger, Friedrich
Published in The Journal of biological chemistry (24.09.2004)
Published in The Journal of biological chemistry (24.09.2004)
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Journal Article
ON104, a novel antibody targeting oxidized Macrophage Migration Inhibitory Factor (oxMIF) shows efficacy in preclinical models of chronic inflammation
FERHAT, Maroua, LANDLINGER, Christine, KERSCHBAUMER, Randolf, TAM, Frederick W. K., NICOLETTI, Ferdinando, THIELE, Michael
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
6547 ON104, A NOVEL BIOENGINEERED ANTIBODY TARGETING OXIDIZED MACROPHAGE MIGRATION INHIBITORY FACTOR (OXMIF) AMELIORATES EXPERIMENTAL GLOMERULONEPHRITIS
Ferhat, Maroua, Kerschbaumer, Randolf, Tam, Frederick, Prendecki, Maria, Costa, Lyndon, Thiele, Michael, Landlinger, Christine
Published in Nephrology, dialysis, transplantation (14.06.2023)
Published in Nephrology, dialysis, transplantation (14.06.2023)
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Journal Article
The newly engineered monoclonal antibody ON104, targeting the oxidized Macrophage Migration Inhibitory Factor (oxMIF), ameliorates clinical and histopathological signs of collagen-induced arthritis
Ferhat, Maroua, Mangano, Katia, Mirkina, Irina, Mayer, Julia, Rossmueller, Gregor, Schinagl, Alexander, Kerschbaumer, Randolf, Nicoletti, Ferdinando, Thiele, Michael, Landlinger, Christine
Published in European journal of pharmacology (05.10.2023)
Published in European journal of pharmacology (05.10.2023)
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Journal Article
Higher expression of fab antibody fragments in a CHO cell line at reduced temperature
Schatz, Simone M., Kerschbaumer, Randolf J., Gerstenbauer, Gabriele, Kral, Martina, Dorner, Friedrich, Scheiflinger, Friedrich
Published in Biotechnology and bioengineering (20.11.2003)
Published in Biotechnology and bioengineering (20.11.2003)
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Journal Article
Pretargeted Radioimmunotherapy with the Novel Anti-oxMIF/HSG Bispecific Antibody ON105 Results in Significant Tumor Regression in Murine Models of Cancer
Puchol Tarazona, Alejandro A, Schinagl, Alexander, Mirkina, Irina, Rossmueller, Gregor, Kerschbaumer, Randolf J, Bachmann, Friedmund, Thiele, Michael
Published in Molecular cancer therapeutics (04.07.2024)
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Published in Molecular cancer therapeutics (04.07.2024)
Journal Article
1059 ON203: A new antibody targeting the oxidized form of macrophage migration inhibitory factor (oxMIF) exerts antitumorigenic activity and modulates the tumor microenvironment
Maurer, Barbara, Mirkina, Irina, Mayer, Julia, Landlinger, Christine, Schinagl, Alexander, Thiele, Michael, Kerschbaumer, Randolf
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article
Abstract 313: Novel bioengineered monoclonal antibodies targeting oxidized macrophage migration inhibitory factor as anti-cancer therapeutics and companion diagnostics
Schinagl, Alexander, Thiele, Michael, Mirkina, Irina, Rossmueller, Gregor, Tarazona, Alejandro A. Puchol, Kerschbaumer, Randolf J.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 2475: A novel class of fully human monoclonal anti-oxMIF antibodies penetrates metastases and accumulates in tumor tissue
Schinagl, Alexander, Thiele, Michael, Douillard, Patrice, Adib, Deyaa, Liu, Xiaochun, Yazji, Salim, Scheiflinger, Friedrich, Kerschbaumer, Randolf
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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