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Adiwijaya, Bambang S, Herrmann, Eva, Hare, Brian, Kieffer, Tara, Lin, Chao, Kwong, Ann D, Garg, Varun, Randle, John C R, Sarrazin, Christoph, Zeuzem, Stefan, Caron, Paul R
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( S )-1-(( S )-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R ,3 S )-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18
Wannamaker, Woods, Davies, Robert, Namchuk, Mark, Pollard, John, Ford, Pamella, Ku, George, Decker, Caroline, Charifson, Paul, Weber, Peter, Germann, Ursula A., Kuida, Keisuke, Randle, John C. R.
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Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist
Wen, Zhiwei, Salmaso, Veronica, Jung, Young-Hwan, Phung, Ngan B, Gopinatth, Varun, Shah, Qasim, Patterson, Alexandra T, Randle, John C. R, Chen, Zhoumou, Salvemini, Daniela, Lieberman, David I, Whitehead, Gregory S, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A
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Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2- a]indeno[1,2- e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists
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Published in Bioorganic & medicinal chemistry letters (18.12.2000)
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Synthesis of anticonvulsive AMPA antagonists: 4-Oxo-10-substituted-imidazo[1,2- a]indeno[1,2- e]pyrazin-2-carboxylic acid derivatives
Stutzmann, Jean-Marie, Bohme, Georg Andrees, Boireau, Alain, Damour, Dominique, Debono, Marc Williams, Genevois-Borella, Arielle, Jimonet, Patrick, Pratt, Jeremy, Randle, John C.R, Ribeill, Yves, Vuilhorgne, Marc, Mignani, Serge
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
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8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones : Highly in vivo potent and selective AMPA receptor antagonists
JIMONET, P, CHEVE, M, RIBEILL, Y, STUTZMANN, J.-M, VUILHORGNE, M, MIGNANI, S, BOHME, G. A, BOIREAU, A, DAMOUR, D, DEBONO, M. W, GENEVOIS-BORELLA, A, IMPERATO, A, PRATT, J, RANDLE, J. C. R
Published in Bioorganic & medicinal chemistry (01.08.2000)
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IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients
Stack, Jeffrey H, Beaumont, Kevin, Larsen, Paul D, Straley, Kimberly S, Henkel, Greg W, Randle, John C. R, Hoffman, Hal M
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Open-label phase 1b pilot study to assess the antiviral efficacy of simvastatin combined with sertraline in chronic hepatitis C patients
Patel, Keyur, Lim, Seng G, Cheng, Chow W, Lawitz, Eric, Tillmann, Hans L, Chopra, Narinder, Altmeyer, Ralf, Randle, John C R, McHutchison, John G
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Published in Journal of medicinal chemistry (15.06.2000)
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MOTHERAM, Rajeshwar, JOSHI, Nitin, LUNSMANN, Walter, Joseph, RANDLE, John, C.R
Year of Publication 28.09.2017
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Year of Publication 28.09.2017
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