Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
Coelho, Matthew A., de Carné Trécesson, Sophie, Rana, Sareena, Zecchin, Davide, Moore, Christopher, Molina-Arcas, Miriam, East, Philip, Spencer-Dene, Bradley, Nye, Emma, Barnouin, Karin, Snijders, Ambrosius P., Lai, Wi S., Blackshear, Perry J., Downward, Julian
Published in Immunity (Cambridge, Mass.) (19.12.2017)
Published in Immunity (Cambridge, Mass.) (19.12.2017)
Get full text
Journal Article
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer
Molina-Arcas, Miriam, Moore, Christopher, Rana, Sareena, van Maldegem, Febe, Mugarza, Edurne, Romero-Clavijo, Pablo, Herbert, Eleanor, Horswell, Stuart, Li, Lian-Sheng, Janes, Matthew R, Hancock, David C, Downward, Julian
Published in Science translational medicine (18.09.2019)
Published in Science translational medicine (18.09.2019)
Get more information
Journal Article
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry
van Maldegem, Febe, Valand, Karishma, Cole, Megan, Patel, Harshil, Angelova, Mihaela, Rana, Sareena, Colliver, Emma, Enfield, Katey, Bah, Nourdine, Kelly, Gavin, Tsang, Victoria Siu Kwan, Mugarza, Edurne, Moore, Christopher, Hobson, Philip, Levi, Dina, Molina-Arcas, Miriam, Swanton, Charles, Downward, Julian
Published in Nature communications (08.10.2021)
Published in Nature communications (08.10.2021)
Get full text
Journal Article
Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF
Wellbrock, Claudia, Rana, Sareena, Paterson, Hugh, Pickersgill, Helen, Brummelkamp, Thijn, Marais, Richard
Published in PloS one (16.07.2008)
Published in PloS one (16.07.2008)
Get full text
Journal Article
Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN‐null triple negative breast cancer
Zecchin, Davide, Moore, Christopher, Michailidis, Fanourios, Horswell, Stuart, Rana, Sareena, Howell, Michael, Downward, Julian
Published in EMBO molecular medicine (07.08.2020)
Published in EMBO molecular medicine (07.08.2020)
Get full text
Journal Article
An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
Boumelha, Jesse, de Carné Trécesson, Sophie, Law, Emily K, Romero-Clavijo, Pablo, Coelho, Matthew A, Ng, Kevin W, Mugarza, Edurne, Moore, Christopher, Rana, Sareena, Caswell, Deborah R, Murillo, Miguel, Hancock, David C, Argyris, Prokopios P, Brown, William L, Durfee, Cameron, Larson, Lindsay K, Vogel, Rachel I, Suárez-Bonnet, Alejandro, Priestnall, Simon L, East, Philip, Ross, Sarah J, Kassiotis, George, Molina-Arcas, Miriam, Swanton, Charles, Harris, Reuben, Downward, Julian
Published in Cancer research (Chicago, Ill.) (04.10.2022)
Published in Cancer research (Chicago, Ill.) (04.10.2022)
Get full text
Journal Article
Wild-Type and Mutant B-RAF Activate C-RAF through Distinct Mechanisms Involving Heterodimerization
Garnett, Mathew J., Rana, Sareena, Paterson, Hugh, Barford, David, Marais, Richard
Published in Molecular cell (22.12.2005)
Published in Molecular cell (22.12.2005)
Get full text
Journal Article
Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade
Anastasiou, Panayiotis, Moore, Christopher, Rana, Sareena, Tomaschko, Mona, Pillsbury, Claire E., de Castro, Andrea, Boumelha, Jesse, Mugarza, Edurne, de Carné Trécesson, Sophie, Mikolajczak, Ania, Blaj, Cristina, Goldstone, Robert, Smith, Jacqueline A. M., Quintana, Elsa, Molina-Arcas, Miriam, Downward, Julian
Published in Nature communications (25.09.2024)
Published in Nature communications (25.09.2024)
Get full text
Journal Article
Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia
Packer, Leisl M., Rana, Sareena, Hayward, Robert, O'Hare, Thomas, Eide, Christopher A., Rebocho, Ana, Heidorn, Sonja, Zabriskie, Matthew S., Niculescu-Duvaz, Ion, Druker, Brian J., Springer, Caroline, Marais, Richard
Published in Cancer cell (13.12.2011)
Published in Cancer cell (13.12.2011)
Get full text
Journal Article
Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach
Pender, Alexandra, Garcia-Murillas, Isaac, Rana, Sareena, Cutts, Rosalind J, Kelly, Gavin, Fenwick, Kerry, Kozarewa, Iwanka, Gonzalez de Castro, David, Bhosle, Jaishree, O'Brien, Mary, Turner, Nicholas C, Popat, Sanjay, Downward, Julian
Published in PloS one (28.09.2015)
Published in PloS one (28.09.2015)
Get full text
Journal Article
871 Combining KRASG12C(ON) inhibitor with SHP2 and/or immune checkpoint blockade to overcome adaptive resistance and enhance anti-tumour immunity in lung cancer
Anastasiou, Panayiotis, Moore, Christopher, Rana, Sareena, Boumelha, Jesse, Tomaschko, Mona, Molina-Arcas, Miriam, Downward, Julian
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
Get full text
Journal Article
A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF
WHITTAKER, Steven, MENARD, Delphine, LAMBROS, Maryou, REIS-FILHO, Jorge S, MARAIS, Richard, SPRINGER, Caroline J, KIRK, Ruth, OGILVIE, Lesley, HEDLEY, Douglas, ZAMBON, Alfonso, LOPES, Filipa, PREECE, Natasha, MANNE, Helen, RANA, Sareena
Published in Cancer research (Chicago, Ill.) (15.10.2010)
Published in Cancer research (Chicago, Ill.) (15.10.2010)
Get full text
Journal Article
Reduced Growth, Increased Vascular Area, and Reduced Response to Cisplatin in CD13-Overexpressing Human Ovarian Cancer Xenografts
VAN HENSBERGEN, Yvette, BROXTERMAN, Henk J, RANA, Sareena, VAN DIEST, Paul J, DUYNDAM, Monique C. A, HOEKMAN, Klaas, PINEDO, Herbert M, BOVEN, Epie
Published in Clinical cancer research (01.02.2004)
Published in Clinical cancer research (01.02.2004)
Get full text
Journal Article
CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer
Boumelha, Jesse, de Castro, Andrea, Bah, Nourdine, Cha, Hongui, de Carné Trécesson, Sophie, Rana, Sareena, Tomaschko, Mona, Anastasiou, Panayiotis, Mugarza, Edurne, Moore, Christopher, Goldstone, Robert, East, Phil, Litchfield, Kevin, Lee, Se-Hoon, Molina-Arcas, Miriam, Downward, Julian
Published in Cancer research (Chicago, Ill.) (15.07.2024)
Published in Cancer research (Chicago, Ill.) (15.07.2024)
Get full text
Journal Article
Aminopeptidase inhibitor bestatin stimulates microvascular endothelial cell invasion in a fibrin matrix
van Hensbergen, Yvette, Broxterman, Henk J, Peters, Erna, Rana, Sareena, Elderkamp, Yvonne W, van Hinsbergh, Victor W M, Koolwijk, Pieter
Published in Thrombosis and haemostasis (01.11.2003)
Published in Thrombosis and haemostasis (01.11.2003)
Get more information
Journal Article
Abstract P111: Therapeutic KRASG12C inhibition alleviates KRAS-driven immunosuppression
Mugarza, Edurne, Van Maldegem, Febe, Boumelha, Jesse, Moore, Chris, Rana, Sareena, Sopena, Miriam Llorian, East, Phil, Arcas, Miriam Molina, Downward, Julian
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
Get full text
Journal Article
Abstract 2987: Identification of new combination therapies for lung tumors harboring KRAS mutations
Molina-Arcas, Miriam, Moore, Christopher, Rana, Sareena, Maldegem, Febe van, Horswell, Stuart, Hancock, David, Downward, Julian
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI 3K pathway inhibitors in PTEN ‐null triple negative breast cancer
Zecchin, Davide, Moore, Christopher, Michailidis, Fanourios, Horswell, Stuart, Rana, Sareena, Howell, Michael, Downward, Julian
Published in EMBO molecular medicine (07.08.2020)
Published in EMBO molecular medicine (07.08.2020)
Get full text
Journal Article
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers
Mugarza, Edurne, van Maldegem, Febe, Boumelha, Jesse, Moore, Christopher, Rana, Sareena, Llorian Sopena, Miriam, East, Philip, Ambler, Rachel, Anastasiou, Panayiotis, Romero-Clavijo, Pablo, Valand, Karishma, Cole, Megan, Molina-Arcas, Miriam, Downward, Julian
Published in Science advances (22.07.2022)
Published in Science advances (22.07.2022)
Get full text
Journal Article