Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist
Clozel, M, Breu, V, Gray, G A, Kalina, B, Loeffler, B-M, Burri, K, Cassal, J-M, Hirth, G, Mueller, M, Neidhart, W
Published in The Journal of pharmacology and experimental therapeutics (01.07.1994)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1994)
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Fragmentation of Bosentan ® (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy: a case of radical fragmentation of an even-electron ion
Hopfgartner, G., Vetter, W., Meister, W., Ramuz, H.
Published in Journal of mass spectrometry. (01.01.1996)
Published in Journal of mass spectrometry. (01.01.1996)
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The dithiane Ro 44-5912 enhances vinblastine sensitivity of drug resistant and parental KB lines in vivo
Eliason, J.F., Sawada, R., Tsukaguchi, T., Kobayashi, K., Ichihara, S., Konishi, C., Horii, I., Kuruma, I., Ramuz, H.
Published in European journal of cancer (1990) (01.12.1995)
Published in European journal of cancer (1990) (01.12.1995)
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Novel Benzo[1,4]diazepin-2-one Derivatives as Endothelin Receptor Antagonists
Bolli, Martin H, Marfurt, Judith, Grisostomi, Corinna, Boss, Christoph, Binkert, Christoph, Hess, Patrick, Treiber, Alexander, Thorin, Eric, Morrison, Keith, Buchmann, Stephan, Bur, Daniel, Ramuz, Henri, Clozel, Martine, Fischli, Walter, Weller, Thomas
Published in Journal of medicinal chemistry (20.05.2004)
Published in Journal of medicinal chemistry (20.05.2004)
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Journal Article
SULFONAMIDE-BASED ANTAGONISTS OF THE ENDOTHELIN RECEPTORS
Burri, Kaspar F., Breu, Volker, Cassal, Jean-Marie, Clozel, Martine, Fischli, Walter, Gray, Gillian A., Hirth, Georges, Löffler, Bernd-Michael, Müller, Marcel, Neidhart, Werner, Ramuz, Henri, Trzeciak, Arnold
Published in European journal of medicinal chemistry (1995)
Published in European journal of medicinal chemistry (1995)
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Conference Proceeding
Pharmacology of Tezosentan, New Endothelin Receptor Antagonist Designed for Parenteral Use
Clozel, M, Ramuz, H, Clozel, J P, Breu, V, Hess, P, Löffler, B M, Coassolo, P, Roux, S
Published in The Journal of pharmacology and experimental therapeutics (01.08.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.08.1999)
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Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist
Clozel, Martine, Breu, Volker, Burri, Kaspar, Cassal, Jean-Marie, Fischli, Walter, Gray, Gillian A, Hirth, Georges, Löffier, Bernd-Michael, Müller, Marcel, Neidhart, Werner, Ramuz, Henri
Published in Nature (London) (21.10.1993)
Published in Nature (London) (21.10.1993)
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Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm
Roux, S, Breu, V, Giller, T, Neidhart, W, Ramuz, H, Coassolo, P, Clozel, J P, Clozel, M
Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Antihypertensive (2-aminoethyl)thiourea derivatives. 2
Tilley, Jefferson W, Ramuz, H, Hefti, F, Gerold, M
Published in Journal of medicinal chemistry (01.12.1980)
Published in Journal of medicinal chemistry (01.12.1980)
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Journal Article
Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan
Neidhart, Werner, Breu, Volker, Burri, Kaspar, Clozel, Martine, Hirth, Georges, Klinkhammer, Uwe, Giller, Thomas, Ramuz, Henri
Published in Bioorganic & medicinal chemistry letters (09.09.1997)
Published in Bioorganic & medicinal chemistry letters (09.09.1997)
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444. Investigations on the biosynthesis of morphine alkaloids
Barton, D. H. R., Kirby, G. W., Steglich, W., Thomas, G. M., Battersby, A. R., Dobson, T. A., Ramuz, H.
Published in Journal of the Chemical Society (1965)
Published in Journal of the Chemical Society (1965)
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Asymmetric Hydrogenation vs. Resolution in the Synthesis of POSICOR®, a New Type of Calcium Antagonist
Yvo Crameri, Rudolf Schmid, Markus Schlageter, Michelangelo Scalone, Henri Ramuz, Frank Kienzle, Christian-Johannes Jenny, Urs Hengartner, Joseph Foricher, Shaoning Wang
Published in Chimia (01.06.1997)
Published in Chimia (01.06.1997)
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Journal Article
The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan
Werner Neidhart, Volker Breu, Daniel Bur, Kaspar Burri, Martine Clozel, Georges Hirth, Marcel Müller, Hans P. Wessel, Henri Ramuz
Published in Chimia (01.11.1996)
Published in Chimia (01.11.1996)
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