Synthesis and structure-activity relationships of pyrazole-based inhibitors of meprin α and β
Tan, Kathrin, Jäger, Christian, Geissler, Stefanie, Schlenzig, Dagmar, Buchholz, Mirko, Ramsbeck, Daniel
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2023)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2023)
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Journal Article
Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
Bayly-Jones, Charles, Lupton, Christopher J., Fritz, Claudia, Venugopal, Hariprasad, Ramsbeck, Daniel, Wermann, Michael, Jäger, Christian, de Marco, Alex, Schilling, Stephan, Schlenzig, Dagmar, Whisstock, James C.
Published in Nature communications (19.10.2022)
Published in Nature communications (19.10.2022)
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Journal Article
Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor
Linnert, Miriam, Fritz, Claudia, Jäger, Christian, Schlenzig, Dagmar, Ramsbeck, Daniel, Kleinschmidt, Martin, Wermann, Michael, Demuth, Hans-Ulrich, Parthier, Christoph, Schilling, Stephan
Published in International journal of molecular sciences (26.05.2021)
Published in International journal of molecular sciences (26.05.2021)
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Journal Article
Prefusion-specific antibody-derived peptides trivalently presented on DNA-nanoscaffolds as an innovative strategy against RSV entry
Issmail, Leila, Möser, Christin, Jäger, Christian, Altattan, Basma, Ramsbeck, Daniel, Kleinschmidt, Martin, Buchholz, Mirko, Smith, David, Grunwald, Thomas
Published in Frontiers in virology (online) (06.10.2022)
Published in Frontiers in virology (online) (06.10.2022)
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Journal Article
Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology
Gnoth, Kathrin, Piechotta, Anke, Kleinschmidt, Martin, Konrath, Sandra, Schenk, Mathias, Taudte, Nadine, Ramsbeck, Daniel, Rieckmann, Vera, Geissler, Stefanie, Eichentopf, Rico, Barendrecht, Susan, Hartlage-Rübsamen, Maike, Demuth, Hans-Ulrich, Roßner, Steffen, Cynis, Holger, Rahfeld, Jens-Ulrich, Schilling, Stephan
Published in Alzheimer's research & therapy (14.11.2020)
Published in Alzheimer's research & therapy (14.11.2020)
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Journal Article
Identification and evaluation of a novel tribenzamide derivative as an inhibitor targeting the entry of the respiratory syncytial virus
Issmail, Leila, Ramsbeck, Daniel, Jäger, Christian, Henning, Tanja, Kleinschmidt, Martin, Buchholz, Mirko, Grunwald, Thomas
Published in Antiviral research (01.03.2023)
Published in Antiviral research (01.03.2023)
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Journal Article
A Diazirine‐Modified Membrane Lipid to Study Peptide/Lipid Interactions – Chances and Challenges
Dorner, Julia, Korn, Patricia, Gruhle, Kai, Ramsbeck, Daniel, Garamus, Vasil M., Lilie, Hauke, Meister, Annette, Schwieger, Christian, Ihling, Christian, Sinz, Andrea, Drescher, Simon
Published in Chemistry : a European journal (21.10.2021)
Published in Chemistry : a European journal (21.10.2021)
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Journal Article
Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors
Ramsbeck, Daniel, Hamann, Antje, Richter, Georg, Schlenzig, Dagmar, Geissler, Stefanie, Nykiel, Vera, Cynis, Holger, Schilling, Stephan, Buchholz, Mirko
Published in Journal of medicinal chemistry (24.05.2018)
Published in Journal of medicinal chemistry (24.05.2018)
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Journal Article
Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis
Schulze, Anja, Wermann, Michael, Demuth, Hans-Ulrich, Yoshimoto, Tadashi, Ramsbeck, Daniel, Schlenzig, Dagmar, Schilling, Stephan
Published in Analytical biochemistry (15.10.2018)
Published in Analytical biochemistry (15.10.2018)
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Journal Article
Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis
Taudte, Nadine, Linnert, Miriam, Rahfeld, Jens-Ulrich, Piechotta, Anke, Ramsbeck, Daniel, Buchholz, Mirko, Kolenko, Petr, Parthier, Christoph, Houston, John A., Veillard, Florian, Eick, Sigrun, Potempa, Jan, Schilling, Stephan, Demuth, Hans-Ulrich, Stubbs, Milton T.
Published in The Journal of biological chemistry (08.01.2021)
Published in The Journal of biological chemistry (08.01.2021)
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Journal Article
Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer’s Disease
Kupski, Oliver, Funk, Lisa-Marie, Sautner, Viktor, Seifert, Franziska, Worbs, Brigitte, Ramsbeck, Daniel, Meyer, Franc, Diederichsen, Ulf, Buchholz, Mirko, Schilling, Stephan, Demuth, Hans-Ulrich, Tittmann, Kai
Published in Biochemistry (Easton) (21.07.2020)
Published in Biochemistry (Easton) (21.07.2020)
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Journal Article
Tertiary‐Amine‐Based Inhibitors of the Astacin Protease Meprin α
Tan, Kathrin, Jäger, Christian, Schlenzig, Dagmar, Schilling, Stephan, Buchholz, Mirko, Ramsbeck, Daniel
Published in ChemMedChem (20.08.2018)
Published in ChemMedChem (20.08.2018)
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Journal Article
Structure–Activity Relationships of Benzimidazole-Based Glutaminyl Cyclase Inhibitors Featuring a Heteroaryl Scaffold
Ramsbeck, Daniel, Buchholz, Mirko, Koch, Birgit, Böhme, Livia, Hoffmann, Torsten, Demuth, Hans-Ulrich, Heiser, Ulrich
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article
Tertiary-Amine-Based Inhibitors of the Astacin Protease Meprin
Tan, Kathrin, Jaeger, Christian, Schlenzig, Dagmar, Schilling, Stephan, Buchholz, Mirko, Ramsbeck, Daniel
Published in ChemMedChem (20.08.2018)
Published in ChemMedChem (20.08.2018)
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Journal Article
A Primary Evaluation of Potential Small‐Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment
Körschgen, Hagen, Jäger, Christian, Tan, Kathrin, Buchholz, Mirko, Stöcker, Walter, Ramsbeck, Daniel
Published in ChemMedChem (19.08.2020)
Published in ChemMedChem (19.08.2020)
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Journal Article
Azide-Modified Membrane Lipids: Synthesis, Properties, and Reactivity
Lindner, Sindy, Gruhle, Kai, Schmidt, Rico, Garamus, Vasil M, Ramsbeck, Daniel, Hause, Gerd, Meister, Annette, Sinz, Andrea, Drescher, Simon
Published in Langmuir (23.05.2017)
Published in Langmuir (23.05.2017)
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Journal Article
Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach
Tan, Kathrin, Jäger, Christian, Körschgen, Hagen, Geissler, Stefanie, Schlenzig, Dagmar, Buchholz, Mirko, Stöcker, Walter, Ramsbeck, Daniel
Published in ChemMedChem (18.03.2021)
Published in ChemMedChem (18.03.2021)
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Journal Article
Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis
Taudte, Nadine, Linnert, Miriam, Rahfeld, Jens-Ulrich, Piechotta, Anke, Ramsbeck, Daniel, Buchholz, Mirko, Kolenko, Petr, Parthier, Christoph, Houston, John A., Veillard, Florian, Eick, Sigrun, Potempa, Jan, Schilling, Stephan, Demuth, Hans-Ulrich, Stubbs, Milton T.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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