On the plasticity of amyloid formation: The impact of destabilizing small to large substitutions on islet amyloid polypeptide amyloid formation
Manathunga, Lakshan, Akter, Rehana, Zhyvoloup, Alexander, Simmerling, Carlos, Raleigh, Daniel P.
Published in Protein science (01.02.2023)
Published in Protein science (01.02.2023)
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Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction
Muir, Tom W, Fierz, Beat, Chatterjee, Champak, McGinty, Robert K, Bar-Dagan, Maya, Raleigh, Daniel P
Published in Nature chemical biology (01.02.2011)
Published in Nature chemical biology (01.02.2011)
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Journal Article
Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology
Cao, Ping, Abedini, Andisheh, Raleigh, Daniel P
Published in Current opinion in structural biology (01.02.2013)
Published in Current opinion in structural biology (01.02.2013)
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Journal Article
Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors
Young, Lydia M, Cao, Ping, Raleigh, Daniel P, Ashcroft, Alison E, Radford, Sheena E
Published in Journal of the American Chemical Society (15.01.2014)
Published in Journal of the American Chemical Society (15.01.2014)
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Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry
Young, Lydia M., Saunders, Janet C., Mahood, Rachel A., Revill, Charlotte H., Foster, Richard J., Tu, Ling-Hsien, Raleigh, Daniel P., Radford, Sheena E., Ashcroft, Alison E.
Published in Nature chemistry (01.01.2015)
Published in Nature chemistry (01.01.2015)
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The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity
Meng, Fanling, Abedini, Andisheh, Plesner, Annette, Verchere, C. Bruce, Raleigh, Daniel P
Published in Biochemistry (Easton) (21.09.2010)
Published in Biochemistry (Easton) (21.09.2010)
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Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet
Buchanan, Lauren E., Dunkelberger, Emily B., Tran, Huong Q., Cheng, Pin-Nan, Chiu, Chi-Cheng, Cao, Ping, Raleigh, Daniel P., de Pablo, Juan J., Nowick, James S., Zanni, Martin T.
Published in Proceedings of the National Academy of Sciences - PNAS (26.11.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (26.11.2013)
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Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity
Cao, Ping, Marek, Peter, Noor, Harris, Patsalo, Vadim, Tu, Ling-Hsien, Wang, Hui, Abedini, Andisheh, Raleigh, Daniel P.
Published in FEBS letters (17.04.2013)
Published in FEBS letters (17.04.2013)
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Journal Article
A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP
Serrano, Arnaldo L, Lomont, Justin P, Tu, Ling-Hsien, Raleigh, Daniel P, Zanni, Martin T
Published in Journal of the American Chemical Society (22.11.2017)
Published in Journal of the American Chemical Society (22.11.2017)
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Journal Article
Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology
Schmidt, Ann Marie, Raleigh, Daniel P., Abedini, Andisheh, Wong, Amy G., Wang, Hui, Tu, Ling-Hsien, Ridgway, Zachary, Noor, Harris, Cao, Ping, Akter, Rehana, Zhang, Xiaoxue
Published in Journal of Diabetes Research (01.01.2016)
Published in Journal of Diabetes Research (01.01.2016)
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Two-Dimensional IR Spectroscopy and Isotope Labeling Defines the Pathway of Amyloid Formation with Residue-Specific Resolution
Shim, Sang-Hee, Gupta, Ruchi, Ling, Yun L., Strasfeld, David B., Raleigh, Daniel P., Zanni, Martin T., Hochstrasser, Robin M.
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2009)
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Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Abedini, Andisheh, Plesner, Annette, Cao, Ping, Ridgway, Zachary, Zhang, Jinghua, Tu, Ling-Hsien, Middleton, Chris T, Chao, Brian, Sartori, Daniel J, Meng, Fanling, Wang, Hui, Wong, Amy G, Zanni, Martin T, Verchere, C Bruce, Raleigh, Daniel P, Schmidt, Ann Marie
Published in eLife (23.05.2016)
Published in eLife (23.05.2016)
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Experiments and simulations show how long-range contacts can form in expanded unfolded proteins with negligible secondary structure
Meng, Wenli, Lyle, Nicholas, Luan, Bowu, Raleigh, Daniel P., Pappu, Rohit V.
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2013)
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Defining the Molecular Basis of Amyloid Inhibitors: Human Islet Amyloid Polypeptide–Insulin Interactions
Susa, Anna C, Wu, Chun, Bernstein, Summer L, Dupuis, Nicholas F, Wang, Hui, Raleigh, Daniel P, Shea, Joan-Emma, Bowers, Michael T
Published in Journal of the American Chemical Society (17.09.2014)
Published in Journal of the American Chemical Society (17.09.2014)
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