Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and Schizophrenia of a Potent and Selective Histamine H3 Receptor Antagonist
Fox, Gerard B, Esbenshade, Timothy A, Pan, Jia Bao, Radek, Richard J, Krueger, Kathleen M, Yao, Betty B, Browman, Kaitlin E, Buckley, Michael J, Ballard, Michael E, Komater, Victoria A, Miner, Holly, Zhang, Min, Faghih, Ramin, Rueter, Lynne E, Bitner, R Scott, Drescher, Karla U, Wetter, Jill, Marsh, Kennan, Lemaire, Martine, Porsolt, Roger D, Bennani, Youssef L, Sullivan, James P, Cowart, Marlon D, Decker, Michael W, Hancock, Arthur A
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
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Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Faghih, Ramin, Gopalakrishnan, Sujatha M, Gronlien, Jens Halvard, Malysz, John, Briggs, Clark A, Wetterstrand, Caroline, Ween, Hilde, Curtis, Michael P, Sarris, Kathy A, Gfesser, Gregory A, El-Kouhen, Rachid, Robb, Holly M, Radek, Richard J, Marsh, Kennan C, Bunnelle, William H, Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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Two Novel and Selective Nonimidazole H3 Receptor Antagonists A-304121 and A-317920: II. In Vivo Behavioral and Neurophysiological Characterization
Fox, Gerard B, Pan, Jia Bao, Radek, Richard J, Lewis, Angela M, Bitner, R Scott, Esbenshade, Timothy A, Faghih, Ramin, Bennani, Youssef L, Williams, Michael, Yao, Betty B, Decker, Michael W, Hancock, Arthur A
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
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TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats
McGaraughty, Steve, Chu, Katharine L, Xu, Jun, Leys, Laura, Radek, Richard J, Dart, Michael J, Gomtsyan, Arthur, Schmidt, Robert G, Kym, Philip R, Brederson, Jill-Desiree
Published in Journal of neurophysiology (01.08.2017)
Published in Journal of neurophysiology (01.08.2017)
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Broad-Spectrum Efficacy across Cognitive Domains by alpha 7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways
Bitner, Robert S, Bunnelle, William H, Anderson, David J, Briggs, Clark A, Buccafusco, Jerry, Curzon, Peter, Decker, Michael W, Frost, Jennifer M, Gronlien, Jens Halvard, Gubbins, Earl, Li, Jinhe, Malysz, John, Markosyan, Stella, Marsh, Kennan, Meyer, Michael D, Nikkel, Arthur L, Radek, Richard J, Robb, Holly M, Timmermann, Daniel, Sullivan, James P, Gopalakrishnan, Murali
Published in The Journal of neuroscience (26.09.2007)
Published in The Journal of neuroscience (26.09.2007)
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Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats
Leys, Laura J., Chu, Katharine L., Xu, Jun, Pai, Madhavi, Yang, He S., Robb, Holly M., Jarvis, Michael F., Radek, Richard J., McGaraughty, Steve
Published in Pain (Amsterdam) (01.07.2013)
Published in Pain (Amsterdam) (01.07.2013)
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Effects of the novel α7 nicotinic acetylcholine receptor agonist ABT-107 on sensory gating in DBA/2 mice: pharmacodynamic characterization
Radek, Richard J, Robb, Holly M, Stevens, Karen E, Gopalakrishnan, Murali, Bitner, Robert S
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
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Rats Housed on Corncob Bedding Show Less Slow-Wave Sleep
Leys, Laura J, McGaraughty, Steve, Radek, Richard J
Published in Journal of the American Association for Laboratory Animal Science (01.11.2012)
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Published in Journal of the American Association for Laboratory Animal Science (01.11.2012)
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Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist
Esbenshade, Timothy A, Browman, Kaitlin E, Miller, Thomas R, Krueger, Kathleen M, Komater-Roderwald, Victoria, Zhang, Min, Fox, Gerard B, Rueter, Lynne, Robb, Holly M, Radek, Richard J, Drescher, Karla U, Fey, Thomas A, Bitner, R Scott, Marsh, Kennan, Polakowski, James S, Zhao, Chen, Cowart, Marlon D, Hancock, Arthur A, Sullivan, James P, Brioni, Jorge D
Published in The Journal of pharmacology and experimental therapeutics (01.10.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2012)
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Journal Article
Preclinical Profiling and Safety Studies of ABT‐769: A Compound with Potential for Broad‐spectrum Antiepileptic Activity
Giardina, William J., Dart, Michael J., Harris, Richard R., Bitner, Robert S., Radek, Richard J., Fox, Gerard B., Chemburkar, Sanjay R., Marsh, Kennan C., Waring, Jeffrey F., Hui, Julia Y, Chen, Jinhua, Curzon, Peter, Grayson, George K., Komater, Victoria A., Ku, Yiyin, Lockwood, Mark, Miner, Holly M., Nikkel, Arthur L., Pan, Jia Bao, Pu, Yu‐Ming, Wang, Lei, Bennani, Youssef, Durmuller, Niklaus, Jolly, Robert, Roux, Sylvain, Sullivan, James P., Decker, Michael W.
Published in Epilepsia (Copenhagen) (01.09.2005)
Published in Epilepsia (Copenhagen) (01.09.2005)
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Journal Article
Broad-Spectrum Efficacy across Cognitive Domains by α7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways
Bitner, Robert S., Bunnelle, William H., Anderson, David J., Briggs, Clark A., Buccafusco, Jerry, Curzon, Peter, Decker, Michael W., Frost, Jennifer M., Gronlien, Jens Halvard, Gubbins, Earl, Li, Jinhe, Malysz, John, Markosyan, Stella, Marsh, Kennan, Meyer, Michael D., Nikkel, Arthur L., Radek, Richard J., Robb, Holly M., Timmermann, Daniel, Sullivan, James P., Gopalakrishnan, Murali
Published in The Journal of neuroscience (26.09.2007)
Published in The Journal of neuroscience (26.09.2007)
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Journal Article
Pharmacological Properties and Procognitive Effects of ABT-288, a Potent and Selective Histamine H 3 Receptor Antagonist
Esbenshade, Timothy A., Browman, Kaitlin E., Miller, Thomas R., Krueger, Kathleen M., Komater-Roderwald, Victoria, Zhang, Min, Fox, Gerard B., Rueter, Lynne, Robb, Holly M., Radek, Richard J., Drescher, Karla U., Fey, Thomas A., Bitner, R. Scott, Marsh, Kennan, Polakowski, James S., Zhao, Chen, Cowart, Marlon D., Hancock, Arthur A., Sullivan, James P., Brioni, Jorge D.
Published in The Journal of pharmacology and experimental therapeutics (01.10.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2012)
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Journal Article
Pharmacological Properties of ABT-239 [4-(2-{2-[(2 R )-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and Schizophrenia of a Potent and Selective Histamine H 3 Receptor Antagonist
Fox, Gerard B., Esbenshade, Timothy A., Pan, Jia Bao, Radek, Richard J., Krueger, Kathleen M., Yao, Betty B., Browman, Kaitlin E., Buckley, Michael J., Ballard, Michael E., Komater, Victoria A., Miner, Holly, Zhang, Min, Faghih, Ramin, Rueter, Lynne E., Bitner, R. Scott, Drescher, Karla U., Wetter, Jill, Marsh, Kennan, Lemaire, Martine, Porsolt, Roger D., Bennani, Youssef L., Sullivan, James P., Cowart, Marlon D., Decker, Michael W., Hancock, Arthur A.
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
Get full text
Journal Article
Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the alpha 7 Nicotinic Acetylcholine Receptor
Faghih, Ramin, Gopalakrishnan, Sujatha M., Gronlien, Jens Halvard, Malysz, John, Briggs, Clark A., Wetterstrand, Caroline, Ween, Hilde, Curtis, Michael P., Sarris, Kathy A., Gfesser, Gregory A., El-Kouhen, Rachid, Robb, Holly M., Radek, Richard J., Marsh, Kennan C., Bunnelle, William H., Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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Journal Article
α4β2 Nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gating
Radek, Richard J., Miner, Holly M., Bratcher, Natalie A., Decker, Michael W., Gopalakrishnan, Murali, Bitner, Robert S.
Published in Psychopharmacology (01.07.2006)
Published in Psychopharmacology (01.07.2006)
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Journal Article
Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
Tietje, Karin R., Anderson, David J., Bitner, R. Scott, Blomme, Eric A., Brackemeyer, Paul J., Briggs, Clark A., Browman, Kaitlin E., Bury, Dagmar, Curzon, Peter, Drescher, Karla U., Frost, Jennifer M., Fryer, Ryan M., Fox, Gerard B., Gronlien, Jens Halvard, Håkerud, Monika, Gubbins, Earl J., Halm, Sabine, Harris, Richard, Helfrich, Rosalind J., Kohlhaas, Kathy L., Law, Devalina, Malysz, John, Marsh, Kennan C., Martin, Ruth L., Meyer, Michael D., Molesky, Angela L., Nikkel, Arthur L., Otte, Stephani, Pan, Liping, Puttfarcken, Pamela S., Radek, Richard J., Robb, Holly M., Spies, Eva, Thorin-Hagene, Kirsten, Waring, Jeffrey F., Ween, Hilde, Xu, Hongyu, Gopalakrishnan, Murali, Bunnelle, William H.
Published in CNS neuroscience & therapeutics (01.03.2008)
Published in CNS neuroscience & therapeutics (01.03.2008)
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Journal Article
Two Novel and Selective Nonimidazole H 3 Receptor Antagonists A-304121 and A-317920: II. In Vivo Behavioral and Neurophysiological Characterization
Fox, Gerard B., Pan, Jia Bao, Radek, Richard J., Lewis, Angela M., Bitner, R. Scott, Esbenshade, Timothy A., Faghih, Ramin, Bennani, Youssef L., Williams, Michael, Yao, Betty B., Decker, Michael W., Hancock, Arthur A.
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
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Journal Article