Search Results - "RACHID, Madani" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy Inhibition

GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy Inhibition

by Bestion, Eloïne, Zandi, Keivan, Belouzard, Sandrine, Andreani, Julien, Lepidi, Hubert, Novello, Marie, Rouquairol, Clara, Baudoin, Jean-Pierre, Rachid, Madani, La Scola, Bernard, Mege, Jean-Louis, Dubuisson, Jean, Schinazi, Raymond F, Mezouar, Soraya, Halfon, Philippe
Published in Viruses (01.01.2022)

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Journal Article

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

by Bestion, Eloïne, Jilkova, Zuzana Macek, Mège, Jean-Louis, Novello, Marie, Kurma, Keerthi, Pour, Seyedeh Tayebeh Ahmad, Lalmanach, Gilles, Vanderlynden, Lise, Fizanne, Lionel, Bassissi, Firas, Rachid, Madani, Tracz, Jennifer, Boursier, Jérôme, Courcambeck, Jérôme, Serdjebi, Cindy, Ansaldi, Christelle, Decaens, Thomas, Halfon, Philippe, Brun, Sonia
Published in Therapeutic advances in chronic disease (2020)

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First-In-Human Effects of PPT1 Inhibition Using the Oral Treatment with GNS561/Ezurpimtrostat in Patients with Primary and Secondary Liver Cancers

First-In-Human Effects of PPT1 Inhibition Using the Oral Treatment with GNS561/Ezurpimtrostat in Patients with Primary and Secondary Liver Cancers

by Harding, James J., Awada, Ahmad, Roth, Gael, Decaens, Thomas, Merle, Philippe, Kotecki, Nuria, Dreyer, Chantal, Ansaldi, Christelle, Rachid, Madani, Mezouar, Soraya, Menut, Agnes, Bestion, Eloïne Nadeige, Paradis, Valérie, Halfon, Philippe, Abou-Alfa, Ghassan K., Raymond, Eric
Published in Liver cancer (Basel ) (01.06.2022)

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Abstract 899: Remarkable anti-tumor response in a HCC transgenic mouse model treated with GNS561 in combination with anti-PD1

Abstract 899: Remarkable anti-tumor response in a HCC transgenic mouse model treated with GNS561 in combination with anti-PD1

by Rachid, Madani, Tijeras-Raballand, Annemilaï, Serdjebi, Cindy, Brun, Sonia, Ansaldi, Christelle, Raymond, Eric, Halfon, Philippe
Published in Cancer research (Chicago, Ill.) (15.08.2020)

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GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

by Brun, Sonia, Bestion, Eloïne, Raymond, Eric, Bassissi, Firas, Jilkova, Zuzana Macek, Mezouar, Soraya, Rachid, Madani, Novello, Marie, Tracz, Jennifer, Hamaï, Ahmed, Lalmanach, Gilles, Vanderlynden, Lise, Legouffe, Raphael, Stauber, Jonathan, Schubert, Thomas, Plach, Maximilian G., Courcambeck, Jérôme, Drouot, Cyrille, Jacquemot, Guillaume, Serdjebi, Cindy, Roth, Gael, Baudoin, Jean-Pierre, Ansaldi, Christelle, Decaens, Thomas, Halfon, Philippe
Published in Autophagy (04.03.2022)

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Journal Article

Targeting p53-dependent stem cell loss for intestinal chemoprotection

Targeting p53-dependent stem cell loss for intestinal chemoprotection

by Leibowitz, Brian J, Yang, Liheng, Wei, Liang, Buchanan, Monica E, Rachid, Madani, Parise, Robert A, Beumer, Jan H, Eiseman, Julie L, Schoen, Robert E, Zhang, Lin, Yu, Jian
Published in Science translational medicine (07.02.2018)

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Journal Article

Ezurpimtrostat, A Palmitoyl-Protein Thioesterase-1 Inhibitor, Combined with PD-1 Inhibition Provides CD8+ Lymphocyte Repopulation in Hepatocellular Carcinoma

Ezurpimtrostat, A Palmitoyl-Protein Thioesterase-1 Inhibitor, Combined with PD-1 Inhibition Provides CD8+ Lymphocyte Repopulation in Hepatocellular Carcinoma

by Bestion, Eloïne, Rachid, Madani, Tijeras-Raballand, Annemilaï, Roth, Gael, Decaens, Thomas, Ansaldi, Christelle, Mezouar, Soraya, Raymond, Eric, Halfon, Philippe
Published in Targeted oncology (01.01.2024)

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Journal Article

First-in-human phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of oral GNS561, a palmitoyl-protein thioesterase 1 (PPT1) inhibitor, in patients with primary and secondary liver malignancies

First-in-human phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of oral GNS561, a palmitoyl-protein thioesterase 1 (PPT1) inhibitor, in patients with primary and secondary liver malignancies

by Harding, James J., Awada, Ahmad, Decaens, Thomas, Roth, Gael, Merle, Philippe, Kotecki, Nuria, Dreyer, Chantal, Ansaldi, Christelle, Rachid, Madani, Mezouar, Soraya, Menut, Agnes, Bestion, Eloine, Paradis, Valerie, Halfon, Philippe, Raymond, Eric, Abou-Alfa, Ghassan K.
Published in Journal of clinical oncology (20.05.2021)

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LC–MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma

LC–MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma

by Kiesel, Brian F., Shogan, Jeffrey C., Rachid, Madani, Parise, Robert A., Vendetti, Frank P., Bakkenist, Christopher J., Beumer, Jan H.
Published in Journal of pharmaceutical and biomedical analysis (10.05.2017)

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Journal Article

Abstract 5479: PGx of gemcitabine in pancreatic ADK: Where did we go wrong

Abstract 5479: PGx of gemcitabine in pancreatic ADK: Where did we go wrong

by SERDJEBI, Cindy, GATTACCECA, Florence, SCHNEIDER, Martina, MONTERYMARD, Carole, CARIO, Jaic, LE MALICOT, Karine, RACHID, Madani, LACARELLE, Bruno, SEITZ, Jean-François, CICCOLINI, Joseph, DAHAN, Laetitia
Published in Cancer research (Chicago, Ill.) (01.08.2015)

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Journal Article

Population Pharmacokinetics of Gemcitabine and dFdU in Pancreatic Cancer Patients Using an Optimal Design, Sparse Sampling Approach

Population Pharmacokinetics of Gemcitabine and dFdU in Pancreatic Cancer Patients Using an Optimal Design, Sparse Sampling Approach

by Serdjebi, Cindy, Gattacceca, Florence, Seitz, Jean-François, Fein, Francine, Gagnière, Johan, François, Eric, Abakar-Mahamat, Abakar, Deplanque, Gael, Rachid, Madani, Lacarelle, Bruno, Ciccolini, Joseph, Dahan, Laetitia
Published in Therapeutic drug monitoring (01.06.2017)

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Journal Article

Phase I study of veliparib in combination with gemcitabine

Phase I study of veliparib in combination with gemcitabine

by Stoller, Ronald, Schmitz, John C., Ding, Fei, Puhalla, Shannon, Belani, Chandra P., Appleman, Leonard, Lin, Yan, Jiang, Yixing, Almokadem, Salah, Petro, Daniel, Holleran, Julianne, Kiesel, Brian F., Ken Czambel, R., Carneiro, Benedito A., Kontopodis, Emmanuel, Hershberger, Pamela A., Rachid, Madani, Chen, Alice, Chu, Edward, Beumer, Jan H.
Published in Cancer chemotherapy and pharmacology (01.09.2017)

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Journal Article

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

by Bestion, Eloïne, Jilkova, Zuzana Macek, Mège, Jean-Louis, Novello, Marie, Kurma, Keerthi, Pour, Seyedeh Tayebeh Ahmad, Lalmanach, Gilles, Vanderlynden, Lise, Fizanne, Lionel, Bassissi, Firas, Rachid, Madani, Tracz, Jennifer, Boursier, Jérôme, Courcambeck, Jérôme, Serdjebi, Cindy, Ansaldi, Christelle, Decaens, Thomas, Halfon, Philippe, Brun, Sonia
Published in Therapeutic advances in chronic disease (01.01.2020)

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Journal Article

SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW MEDICAMENT FOR FIBROSIS, AUTOPHAGY AND CATHEPSINS B (CTSB), L (CTSL) AND D (CTSD) RELATED DISEASES

SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW MEDICAMENT FOR FIBROSIS, AUTOPHAGY AND CATHEPSINS B (CTSB), L (CTSL) AND D (CTSD) RELATED DISEASES

by RACHID, Madani, BRUN, Sonia, HALFON, Philippe, COURCAMBECK, Jérôme, BASSISSI, Firas
Year of Publication 29.06.2022

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Patent

Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases

Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases

by Brun, Sonia, Halfon, Philippe, Courcambeck, Jérôme, Bassissi, Firas, Rachid, Madani
Year of Publication 01.03.2022

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Patent

2,4-DIAMINO-QUINOLÉINE SUBSTITUÉE EN TANT QUE NOUVEAU MÉDICAMENT POUR LA FIBROSE, L'AUTOPHAGIE ET LES MALADIES ASSOCIÉES AUX CATHEPSINES B (CTSB), L (CTSL) ET D (CTSD)

2,4-DIAMINO-QUINOLÉINE SUBSTITUÉE EN TANT QUE NOUVEAU MÉDICAMENT POUR LA FIBROSE, L'AUTOPHAGIE ET LES MALADIES ASSOCIÉES AUX CATHEPSINES B (CTSB), L (CTSL) ET D (CTSD)

by RACHID, Madani, BRUN, Sonia, COURCAMBECK, Jérôme, HALFON, Philippe, BASSISSI, Firas
Year of Publication 15.12.2021

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Patent

SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW MEDICAMENT FOR FIBROSIS, AUTOPHAGY AND CATHEPSINS B (CTSB), L (CTSL) AND D (CTSD) RELATED DISEASES

SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW MEDICAMENT FOR FIBROSIS, AUTOPHAGY AND CATHEPSINS B (CTSB), L (CTSL) AND D (CTSD) RELATED DISEASES

by RACHID, Madani, BRUN, Sonia, HALFON, Philippe, COURCAMBECK, Jérôme, BASSISSI, Firas
Year of Publication 14.07.2021

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Patent

Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases

Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases

by Brun, Sonia, Halfon, Philippe, Courcambeck, Jérôme, Bassissi, Firas, Rachid, Madani
Year of Publication 12.03.2020

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Patent

SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW MEDICAMENT FOR FIBROSIS, AUTOPHAGY AND CATHEPSINS B (CTSB), L (CTSL) AND D (CTSD) RELATED DISEASES

SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW MEDICAMENT FOR FIBROSIS, AUTOPHAGY AND CATHEPSINS B (CTSB), L (CTSL) AND D (CTSD) RELATED DISEASES

by RACHID, Madani, BRUN, Sonia, HALFON, Philippe, COURCAMBECK, Jérôme, BASSISSI, Firas
Year of Publication 12.03.2020

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Patent

SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW MEDICAMENT FOR FIBROSIS, AUTOPHAGY AND CATHEPSINS B (CTSB), L (CTSL) AND D (CTSD) RELATED DISEASES

SUBSTITUTED 2,4 DIAMINO-QUINOLINE AS NEW MEDICAMENT FOR FIBROSIS, AUTOPHAGY AND CATHEPSINS B (CTSB), L (CTSL) AND D (CTSD) RELATED DISEASES

by BRUN, SONIA, HALFON, PHILIPPE, BASSISSI, FIRAS, COURCAMBECK, JEROME, RACHID, MADANI
Year of Publication 12.03.2020

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Patent