Granzyme B–Mediated Death of Pancreatic β-Cells Requires the Proapoptotic BH3-Only Molecule Bid
ESTELLA, Eugene, MCKENZIE, Mark D, CATTERALL, Tara, SUTTON, Vivien R, BIRD, Phillip I, TRAPANI, Joseph A, KAY, Thomas W, THOMAS, Helen E
Published in Diabetes (New York, N.Y.) (01.08.2006)
Published in Diabetes (New York, N.Y.) (01.08.2006)
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Journal Article
Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors
Gartlan, Kate H., Jaiswal, Jagdish K., Bull, Matthew R., Akhlaghi, Hedieh, Sutton, Vivien R., Alexander, Kylie A., Chang, Karshing, Hill, Geoffrey R., Miller, Christian K., O’Connor, Patrick D., Jose, Jiney, Trapani, Joseph A., Charman, Susan A., Spicer, Julie A., Jamieson, Stephen M. F.
Published in ACS pharmacology & translational science (10.06.2022)
Published in ACS pharmacology & translational science (10.06.2022)
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Journal Article
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis
Sutton, Vivien R, Waterhouse, Nigel J, Browne, Kylie A, Sedelies, Karin, Ciccone, Annette, Anthony, Desiree, Koskinen, Aulikki, Mullbacher, Arno, Trapani, Joseph A
Published in The Journal of cell biology (12.02.2007)
Published in The Journal of cell biology (12.02.2007)
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Journal Article
Unlocking the secrets of cytotoxic granule proteins
Smyth, Mark J., Kelly, Janice M., Sutton, Vivien R., Davis, Joanne E., Browne, Kylie A., Sayers, Thomas J., Trapani, Joseph A.
Published in Journal of leukocyte biology (01.07.2001)
Published in Journal of leukocyte biology (01.07.2001)
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Journal Article
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells
Hoves, Sabine, Sutton, Vivien R, Haynes, Nicole M, Hawkins, Edwin D, Fernández Ruiz, Daniel, Baschuk, Nikola, Sedelies, Karin A, Schnurr, Maximilian, Stagg, John, Andrews, Daniel M, Villadangos, Jose A, Trapani, Joseph A
Published in The Journal of immunology (1950) (01.08.2011)
Published in The Journal of immunology (1950) (01.08.2011)
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Journal Article
Dihydrofuro[3,4-c]pyridinones as Inhibitors of the Cytolytic Effects of the Pore-Forming Glycoprotein Perforin
Lena, Gersande, Trapani, Joseph A, Sutton, Vivien R, Ciccone, Annette, Browne, Kylie A, Smyth, Mark J, Denny, William A, Spicer, Julie A
Published in Journal of medicinal chemistry (11.12.2008)
Published in Journal of medicinal chemistry (11.12.2008)
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Journal Article
Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
Waterhouse, Nigel J, Sutton, Vivien R, Sedelies, Karin A, Ciccone, Annette, Jenkins, Misty, Turner, Stephen J, Bird, Phillip I, Trapani, Joseph A
Published in The Journal of cell biology (10.04.2006)
Published in The Journal of cell biology (10.04.2006)
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Journal Article
Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo
Trapani, Joseph A, Davis, Joanne, Sutton, Vivien R, Smyth, Mark J
Published in Current Opinion in Immunology (01.06.2000)
Published in Current Opinion in Immunology (01.06.2000)
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Journal Article
A Clathrin/Dynamin- and Mannose-6-Phosphate Receptor-Independent Pathway for Granzyme B-Induced Cell Death
Trapani, Joseph A., Sutton, Vivien R., Kevin Y. T. Thia, Li, Yu Qin, Froelich, Christopher J., Jans, David A., Sandrin, Mauro S., Browne, Kylie A.
Published in The Journal of cell biology (20.01.2003)
Published in The Journal of cell biology (20.01.2003)
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Journal Article
Cytosolic Delivery of Granzyme B by Bacterial Toxins: Evidence that Endosomal Disruption, in Addition to Transmembrane Pore Formation, Is an Important Function of Perforin
Browne, Kylie A., Blink, Elizabeth, Sutton, Vivien R., Froelich, Christopher J., Jans, David A., Trapani, Joseph A.
Published in Molecular and Cellular Biology (01.12.1999)
Published in Molecular and Cellular Biology (01.12.1999)
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Journal Article
Selective Regulation of Apoptosis: the Cytotoxic Lymphocyte Serpin Proteinase Inhibitor 9 Protects against Granzyme B-Mediated Apoptosis without Perturbing the Fas Cell Death Pathway
Bird, Catherina H., Sutton, Vivien R., Sun, Jiuru, Hirst, Claire E., Novak, Andrea, Kumar, Sharad, Trapani, Joseph A., Bird, Phillip I.
Published in Molecular and Cellular Biology (01.11.1998)
Published in Molecular and Cellular Biology (01.11.1998)
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Journal Article
Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent
Trapani, Joseph A., Jans, David A., Jans, Patricia J., Smyth, Mark J., Browne, Kylie A., Sutton, Vivien R.
Published in The Journal of biological chemistry (23.10.1998)
Published in The Journal of biological chemistry (23.10.1998)
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Journal Article
Quantitative scoring of an interferon-{gamma} assay for differentiating active from latent tuberculosis
Janssens, J-P, Roux-Lombard, P, Perneger, T, Metzger, M, Vivien, R, Rochat, T
Published in The European respiratory journal (01.10.2007)
Published in The European respiratory journal (01.10.2007)
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Journal Article
Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction
Hirst, Claire E., Buzza, Marguerite S., Sutton, Vivien R., Trapani, Joseph A., Loveland, Kate L., Bird, Phillip I.
Published in Molecular human reproduction (01.12.2001)
Published in Molecular human reproduction (01.12.2001)
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