Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs
Bradley, Sophie J, Molloy, Colin, Valuskova, Paulina, Dwomoh, Louis, Scarpa, Miriam, Rossi, Mario, Finlayson, Lisa, Svensson, Kjell A, Chernet, Eyassu, Barth, Vanessa N, Gherbi, Karolina, Sykes, David A, Wilson, Caroline A, Mistry, Rajendra, Sexton, Patrick M, Christopoulos, Arthur, Mogg, Adrian J, Rosethorne, Elizabeth M, Sakata, Shuzo, John Challiss, R A, Broad, Lisa M, Tobin, Andrew B
Published in Nature chemical biology (01.03.2020)
Published in Nature chemical biology (01.03.2020)
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Increased Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Expression Mediates Intrinsic Airway Smooth Muscle Hypercontractility in Asthma
SUTCLIFFE, Amanda, HOLLINS, Fay, GOMEZ, Edith, SAUNDERS, Ruth, DOE, Camille, COOKE, Marcus, JOHN CHALLISS, R. A, BRIGHTLING, Chris E
Published in American journal of respiratory and critical care medicine (01.02.2012)
Published in American journal of respiratory and critical care medicine (01.02.2012)
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Journal Article
Alternative splicing of G protein-coupled receptors: physiology and pathophysiology
Markovic, Danijela, Challiss, R. A. John
Published in Cellular and molecular life sciences : CMLS (01.10.2009)
Published in Cellular and molecular life sciences : CMLS (01.10.2009)
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Journal Article
Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B
Brignell, Jennifer L, Perry, Matthew D, Nelson, Carl P, Willets, Jonathon M, Challiss, R A John, Davies, Noel W
Published in PloS one (20.03.2015)
Published in PloS one (20.03.2015)
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Journal Article
Regulation of neuronal plasticity and fear by a dynamic change in PAR1―G protein coupling in the amygdala
BOURGOGNON, J.-M, SCHIAVON, E, PAWLAK, R, SALAH-UDDIN, H, SKRZYPIEC, A. E, ATTWOOD, B. K, SHAH, R. S, PATEL, S. G, MUCHA, M, CHALLISS, Ra John, FORSYTHE, I. D
Published in Molecular psychiatry (01.10.2013)
Published in Molecular psychiatry (01.10.2013)
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Journal Article
HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4
Di Candia, Leonarda, PhD, Gomez, Edith, PhD, Venereau, Emilie, PhD, Chachi, Latifa, PhD, Kaur, Davinder, PhD, Bianchi, Marco E., PhD, Challiss, R.A. John, PhD, Brightling, Christopher E., MD, PhD, FCCP, Saunders, Ruth M., PhD
Published in Journal of allergy and clinical immunology (01.08.2017)
Published in Journal of allergy and clinical immunology (01.08.2017)
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Journal Article
FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists
Markovic, Danijela, Holdich, Jonathan, Al-Sabah, Suleiman, Mistry, Rajendra, Krasel, Cornelius, Mahaut-Smith, Martyn P, Challiss, R A John
Published in PloS one (2012)
Published in PloS one (2012)
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Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability
Robinson, Susan W, Bourgognon, Julie-Myrtille, Spiers, Jereme G, Breda, Carlo, Campesan, Susanna, Butcher, Adrian, Mallucci, Giovanna R, Dinsdale, David, Morone, Nobuhiro, Mistry, Raj, Smith, Tim M, Guerra-Martin, Maria, Challiss, R A John, Giorgini, Flaviano, Steinert, Joern R
Published in PLoS biology (09.04.2018)
Published in PLoS biology (09.04.2018)
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Journal Article
Endogenous G Protein-coupled Receptor Kinase 6 Regulates M3 Muscarinic Acetylcholine Receptor Phosphorylation and Desensitization in Human SH-SY5Y Neuroblastoma Cells
Willets, Jonathon M., Challiss, R. A. John, Nahorski, Stefan R.
Published in The Journal of biological chemistry (03.05.2002)
Published in The Journal of biological chemistry (03.05.2002)
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Journal Article
Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse
Steinert, Joern R., Kopp-Scheinpflug, Cornelia, Baker, Claire, Challiss, R.A. John, Mistry, Raj, Haustein, Martin D., Griffin, Sarah J., Tong, Huaxia, Graham, Bruce P., Forsythe, Ian D.
Published in Neuron (Cambridge, Mass.) (26.11.2008)
Published in Neuron (Cambridge, Mass.) (26.11.2008)
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Journal Article
Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose
Jackson, Robert, Brennan, Sean, Fielding, Peter, Sims, Mark W, Challiss, RA John, Adlam, David, Squire, Iain B, Rainbow, Richard D
Published in British journal of pharmacology (01.03.2016)
Published in British journal of pharmacology (01.03.2016)
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Journal Article
Contrasting Effects of Allosteric and Orthosteric Agonists on M1 Muscarinic Acetylcholine Receptor Internalization and Down-regulation
Thomas, Rachel L, Langmead, Christopher J, Wood, Martyn D, Challiss, R A John
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
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Journal Article
Arrestins differentially regulate histamine‐ and oxytocin‐evoked phospholipase C and mitogen‐activated protein kinase signalling in myometrial cells
Brighton, Paul J, Rana, Shashi, Challiss, RA John, Konje, Justin C, Willets, Jonathon M
Published in British journal of pharmacology (01.04.2011)
Published in British journal of pharmacology (01.04.2011)
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Journal Article
Single Cell Analysis and Temporal Profiling of Agonist-mediated Inositol 1,4,5-Trisphosphate, Ca2+, Diacylglycerol, and Protein Kinase C Signaling using Fluorescent Biosensors
Bartlett, Paula J., Young, Kenneth W., Nahorski, Stefan R., Challiss, R. A. John
Published in The Journal of biological chemistry (10.06.2005)
Published in The Journal of biological chemistry (10.06.2005)
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Journal Article
GRK2 expression and catalytic activity are essential for vasoconstrictor/ERK-stimulated arterial smooth muscle proliferation
Alonazi, Asma, Nash, Craig A., Wang, Chuan-Han, Christofidou, Elena, Challiss, R.A. John, Willets, Jonathon M.
Published in Biochemical pharmacology (01.10.2023)
Published in Biochemical pharmacology (01.10.2023)
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Journal Article
Visualizing the temporal effects of vasoconstrictors on PKC translocation and Ca2+ signaling in single resistance arterial smooth muscle cells
Nelson, Carl P, Willets, Jonathon M, Davies, Noel W, Challiss, R. A. John, Standen, Nicholas B
Published in American Journal of Physiology: Cell Physiology (01.12.2008)
Published in American Journal of Physiology: Cell Physiology (01.12.2008)
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Journal Article
Imaging of Muscarinic Acetylcholine Receptor Signaling in Hippocampal Neurons: Evidence for Phosphorylation-Dependent and -Independent Regulation by G-Protein-Coupled Receptor Kinases
Willets, Jonathon M, Nash, Mark S, Challiss, R. A. John, Nahorski, Stefan R
Published in The Journal of neuroscience (28.04.2004)
Published in The Journal of neuroscience (28.04.2004)
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